Sifasi 5000 Inj

SIFASI 5000 INJ

SIFASI 5000 INJ is a pharmaceutical product manufactured by Serum Institute of India Pvt Ltd.

• Name: SIFASI 5000 INJ (also known as Sifasi Aqua 5000 Injection, Sifasi 5000 IU Injection).

• Composition: Each vial contains lyophilized Human Chorionic Gonadotropin (hCG) I.P. 5000 IU.

• Uses:

  • Female Infertility: Used to stimulate ovulation (egg production) in women, especially those with secondary ovarian failure or polycystic ovary syndrome, and as part of assisted reproductive techniques like in-vitro fertilization (IVF) to trigger final follicle maturation.
  • Male Hypogonadism: Stimulates testosterone production in men with pituitary hormone deficiencies, aiding in the treatment of delayed puberty and low sperm count.
  • Cryptorchidism: Used in boys aged 4 to 9 where testes have not descended into the scrotum, provided there is no structural deformity.

• Dosage and Administration:

  • SIFASI 5000 INJ is administered as an injection, either intramuscularly (IM) or subcutaneously (SC), by a healthcare professional.
  • The powder in the ampoule should be reconstituted with the provided diluent just prior to use.
  • The dosage and frequency are determined by the doctor based on the patient's condition and response to treatment.

• Side Effects:

  • Common: Pain, redness, and swelling at the injection site, headache, fatigue, irritability, restlessness, oedema (swelling/fluid retention), nausea, vomiting, abdominal discomfort or pain, mood changes, depression, sleeplessness. In men, acne, sweating, deepening of the voice, and breast enlargement (gynecomastia) may occur. Early puberty can be seen in children.
  • Serious: Ovarian Hyperstimulation Syndrome (OHSS), characterized by severe pelvic pain, decreased urination, rapid weight gain, severe stomach pain or bloating, chest pain, or shortness of breath. Other serious effects can include blood clots.

• Precautions:

  • Pregnancy: Not recommended for use in pregnant women as it may be unsafe and cause birth defects, except in specific cases like supporting early pregnancy in IVF where benefits outweigh risks.
  • Breastfeeding: Use with caution in breastfeeding mothers; consult a doctor.
  • Contraindications: Allergy to chorionic gonadotropin, early puberty, prostatic cancer or other androgen-dependent cancers, unexplained vaginal bleeding, uncontrolled thyroid or adrenal gland dysfunction, ovarian cysts or enlargement (not due to PCOS), tumors of the hypothalamus or pituitary gland, recent extrauterine pregnancy, and blood clotting disorders.
  • Other Warnings: Caution is advised in patients with liver or kidney problems, epilepsy, migraine, asthma, or cardiovascular/pulmonary disease due to potential fluid retention. This medicine may increase the risk of multiple pregnancies. Avoid alcohol or use with caution.

• Storage:

  • Store in a refrigerator at 2°C to 8°C.
  • Do not freeze.
  • Keep out of sight and reach of children.
  • Store in a cool and dry place away from sunlight.

Here are the most frequently asked questions about SIFASI 5000 INJ:

What is SIFASI 5000 INJ used for?

SIFASI 5000 INJ is primarily used in fertility treatments. In women, it helps in the normal development of eggs within the ovaries and stimulates ovulation (egg release), particularly in cases of female infertility or as part of in vitro fertilization (IVF). In men, it is used to treat male hypogonadism by stimulating testosterone production, which can help with delayed puberty and low sperm count. It is also used to treat cryptorchidism (undescended testicles) in young boys.

How does SIFASI 5000 INJ work?

SIFASI 5000 INJ contains Human Chorionic Gonadotropin (hCG), which mimics the action of luteinizing hormone (LH), a natural hormone in the body essential for reproduction and fertility. In women, it stimulates the ovaries to produce progesterone and promotes the release of a mature egg. In men, it stimulates specific cells in the testicles to produce androgens, including testosterone.

What is the usual dosage of SIFASI 5000 INJ?

SIFASI 5000 INJ is administered as an injection, either into a muscle or under the skin, by a healthcare professional. The specific dosage and frequency are determined by your doctor based on your medical condition and how your body responds to the treatment. It often comes as a powder that needs to be mixed with a sterile diluent before administration.

What are the possible side effects of SIFASI 5000 INJ?

Common side effects may include pain, redness, or swelling at the injection site, headache, fatigue, irritability, restlessness, nausea, vomiting, abdominal pain or discomfort, fluid retention (oedema), and mood changes. More serious, but less common, side effects can include Ovarian Hyperstimulation Syndrome (OHSS) in women (symptoms like severe pelvic pain, rapid weight gain, difficulty breathing, decreased urination), early puberty in children, gynecomastia (breast enlargement) in men, or allergic reactions. You should seek immediate medical attention if you experience severe symptoms.

Is SIFASI 5000 INJ safe during pregnancy or breastfeeding?

SIFASI 5000 INJ is generally not recommended for use during pregnancy as it may cause harm to the developing fetus or birth defects. While there might be exceptions for supporting early pregnancy in IVF cases, caution is still advised. For breastfeeding mothers, it should be used with caution, and breastfeeding may need to be discontinued during treatment, as the effects on a nursing baby are not fully known. Always consult your doctor to discuss the risks and benefits.

Can SIFASI 5000 INJ be taken with other medications?

It is crucial to inform your doctor about all medications you are currently taking, including prescription drugs, over-the-counter medicines, herbal remedies, and supplements, as interactions can occur. Certain medications, such as some anticonvulsants (e.g., phenytoin) and ulcer medications (e.g., ranitidine), may reduce the effectiveness of SIFASI 5000 INJ. Also, if used with menotropins in women for infertility, there is an increased risk of multiple pregnancies. Gonadotropin-releasing hormone (GnRH) agonists/antagonists might also reduce the response to SIFASI 5000 INJ.

What precautions should be taken while using SIFASI 5000 INJ?

Do not self-inject this medicine; it must be administered by a healthcare professional. Inform your doctor if you have any allergies (especially to hCG), a history of early puberty, prostate cancer, unexplained vaginal bleeding, ovarian cysts, thyroid or adrenal gland dysfunction, epilepsy, migraine, asthma, or kidney/liver problems. There is a risk of developing Ovarian Hyperstimulation Syndrome (OHSS) in women, so watch for symptoms like severe abdominal pain or rapid weight gain. Caution is also advised regarding alcohol consumption while on this medication.

What happens if a dose of SIFASI 5000 INJ is missed?

Since SIFASI 5000 INJ is typically administered by a doctor or nurse in a clinical setting, missed doses are less common. However, if you believe you have missed a scheduled dose, you should contact your doctor or healthcare provider immediately for instructions. Do not attempt to take a double dose to make up for a missed one.

How should SIFASI 5000 INJ be stored?

SIFASI 5000 INJ should be stored in a refrigerator at a temperature between 2°C and 8°C (36°F and 46°F). It is important not to freeze the medicine. Always keep it out of the reach and sight of children and pets, and protect it from light.