Trajenta Duo 2.5mg/1000mg Tablet

TRAJENTA DUO 2.5MG/1000MG TABLET

Name:

• Brand Name: TRAJENTA DUO 2.5MG/1000MG TABLET
• Common Name: Linagliptin and Metformin Hydrochloride Tablets

Composition: Each film-coated tablet contains:

• Linagliptin: 2.5 mg
• Metformin Hydrochloride: 1000 mg

Uses: TRAJENTA DUO 2.5MG/1000MG TABLET is prescribed for adults with Type 2 Diabetes Mellitus as an adjunct to diet and exercise to improve glycemic control. It is used when treatment with both linagliptin and metformin is appropriate, particularly when diet and exercise alone are insufficient, or when other conventional medicines do not result in adequate sugar control. This medication works by:

• Helping the body produce more insulin when required.
• Reducing the amount of sugar produced by the liver.
• Delaying glucose absorption from the intestines.
• Increasing the body's sensitivity to insulin. By effectively managing diabetes, it helps prevent serious complications such as kidney damage, eye damage (retinopathy), nerve problems (neuropathy), and may reduce the risk of heart attack or stroke.

Dosage and Administration:

• The recommended dose is typically 2.5 mg linagliptin/1000 mg metformin hydrochloride twice daily.
• TRAJENTA DUO should be taken with meals to minimize gastrointestinal side effects associated with metformin.
• Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
• It is advised to take it at the same time each day for best results.
• Do not skip a dose or discontinue treatment without consulting your doctor, as this may lead to an increase in blood sugar levels.

Side Effects: Common Side Effects:

• Hypoglycemia (low blood glucose levels), characterized by dizziness, sweating, palpitations, hunger pangs, dry mouth, and skin. It is important to carry a form of sugar for immediate relief.
• Taste change
• Nausea
• Diarrhea
• Stomach pain/abdominal pain
• Headache
• Upper respiratory symptoms (e.g., runny nose, sore throat, nasopharyngitis).

Serious Side Effects:

• Lactic Acidosis: A rare but serious condition, particularly in patients with kidney disease, elderly patients, or those who consume large amounts of alcohol. Symptoms include muscle pain or weakness, dizziness, tiredness, feeling cold in arms and legs, difficulty breathing, nausea, vomiting, or stomach pain.
• Pancreatitis (inflammation of the pancreas).
• Vitamin B12 deficiency (with long-term use).

Precautions:

• Inform your doctor if you have a history of pancreatitis, kidney disease, liver disease, heart disease, or a low vitamin B12 level.
• Avoid alcohol consumption as it can lower blood sugar levels and increase the risk of lactic acidosis.
• Not recommended for use in patients with Type 1 diabetes or diabetic ketoacidosis.
• Caution is advised in pregnant and breastfeeding women; consult a doctor.
• When used with insulin or sulfonylureas, a lower dose of these medications may be required to reduce the risk of hypoglycemia.
• Regular monitoring of blood sugar levels and kidney function is essential during treatment.
• Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements, due to potential drug interactions.
• Prolonged intake may lower thyroid-stimulating hormone (TSH); an annual TSH checkup is recommended.

Storage:

• Store in a cool and dry place away from sunlight.
• Do not store above 30°C.
• Store in the original package to protect from moisture.
• Keep out of sight and reach of children.
• Non-cold chain: To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What is TRAJENTA DUO 2.5mg/1000mg Tablet used for?

TRAJENTA DUO 2.5mg/1000mg Tablet is used to treat Type 2 Diabetes Mellitus in adults. It's prescribed when diet and exercise alone, or treatment with linagliptin or metformin alone, are not enough to control blood sugar levels. It can also be used as an add-on therapy with insulin for better glycemic control.

How does TRAJENTA DUO 2.5mg/1000mg Tablet work?

This medicine contains two active ingredients: Linagliptin and Metformin. Linagliptin is a DPP-4 inhibitor that helps the body produce more insulin when needed and reduces the amount of sugar produced by the liver when it's not required. Metformin is a biguanide that works by lowering glucose production in the liver, delaying glucose absorption from the intestines, and increasing the body's sensitivity to insulin. Together, they prevent blood glucose levels from rising too high, especially after meals.

What is the usual dosage for TRAJENTA DUO 2.5mg/1000mg Tablet?

The recommended dose is typically 2.5mg/500mg, 2.5mg/850mg, or 2.5mg/1000mg twice daily. The dosage should be individualized by your doctor based on your current regimen, effectiveness, and tolerability, but the maximum recommended daily dose is 5 mg of linagliptin and 2000 mg of metformin. It should be taken with meals to minimize gastrointestinal side effects.

What are the possible side effects of TRAJENTA DUO 2.5mg/1000mg Tablet?

Common side effects can include hypoglycemia (low blood glucose levels), which may cause dizziness, sweating, hunger pangs, and dry mouth. Other common side effects are changes in taste, nausea, diarrhea, stomach pain, headache, upper respiratory tract infection, and nasopharyngitis (inflammation of the nose and throat). A rare but serious side effect is lactic acidosis, characterized by symptoms like muscle pain, difficulty breathing, and unusual tiredness. Long-term use may also lead to vitamin B12 deficiency.

Is TRAJENTA DUO 2.5mg/1000mg Tablet safe during pregnancy or breastfeeding?

TRAJENTA DUO is generally not recommended during pregnancy due to limited data and potential risks to the baby. If pregnancy occurs or is planned, treatment should be discontinued and switched to insulin as soon as possible to reduce the risk of fetal malformations associated with abnormal blood glucose levels. It is also not recommended during breastfeeding, as components of the medicine are known to pass into breast milk.

Can TRAJENTA DUO 2.5mg/1000mg Tablet be taken with other medications?

TRAJENTA DUO can interact with other medications. Co-administration with insulin or sulfonylureas may increase the risk of hypoglycemia, potentially requiring a lower dose of those medications. Carbonic anhydrase inhibitors (e.g., topiramate) may increase the risk of lactic acidosis. Certain heart medications like digoxin may increase metformin levels. It's important to inform your doctor about all medicines and supplements you are taking to ensure safety.

What precautions should be taken when using TRAJENTA DUO 2.5mg/1000mg Tablet?

Avoid excessive alcohol consumption, as it can lower blood sugar and increase the risk of lactic acidosis. Regular monitoring of kidney function is crucial, especially for elderly patients or those with kidney impairment, as TRAJENTA DUO is contraindicated in severe renal failure. It should not be used for Type 1 diabetes or diabetic ketoacidosis. Inform your doctor if you have a history of pancreatitis, liver disease, or heart failure. Discontinue the medication before or during imaging procedures involving iodinated contrast agents and certain surgeries.

What happens if a dose is missed?

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the missed one.

How should TRAJENTA DUO 2.5mg/1000mg Tablet be stored?

TRAJENTA DUO should be stored in a cool and dry place, below 30°C, and kept in its original package to protect it from moisture. Keep it out of sight and reach of children and pets.