Justoza S 10/100mg Tab

Justoza S 10/100mg Tablet

Justoza S 10/100mg Tablet is a prescription medication manufactured by Mankind Pharma Ltd., used for the management of Type 2 Diabetes Mellitus.

• Composition: Each tablet contains Dapagliflozin 10 mg and Sitagliptin 100 mg.

  • Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT-2) inhibitor that works by blocking glucose reabsorption in the kidneys, leading to increased glucose excretion through urine.
  • Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that enhances insulin secretion and reduces glucose production by the liver, especially after meals.

• Uses: This medicine is primarily used to control high blood sugar levels in adults with Type 2 Diabetes Mellitus, particularly when diet, exercise, or other medications alone are insufficient. It also helps reduce the risk of diabetes-related complications such as kidney damage, nerve damage, and cardiovascular events. Justoza S 10/100mg Tablet may also be used to treat chronic kidney disease in adults with reduced kidney function.

• Dosage and Administration: Justoza S 10/100mg Tablet should be taken orally once daily, with or without food, as directed by a healthcare professional. It is recommended to take it at the same time each day for optimal benefits. Do not crush, break, or chew the tablet.

• Side Effects: Common side effects include urinary tract infections (UTIs), nasal congestion, sore throat, upper respiratory tract infections, and genital fungal infections. Other reported side effects include diarrhea, headache, nausea, vomiting, and dizziness. Serious side effects can include very low blood sugar (especially when combined with insulin or sulphonylureas), symptoms of acute pancreatitis, and severe allergic reactions.

• Precautions: Consult your doctor before taking this medicine if you have Type 1 diabetes, diabetic ketoacidosis, kidney or liver issues, heart failure, or a history of pancreatitis. Caution is advised during pregnancy (contraindicated in the second and third trimesters due to dapagliflozin) and breastfeeding. Alcohol consumption should be avoided as it can increase the risk of side effects and affect blood sugar levels. Inform your doctor about all other medications, especially diuretics, as interactions can occur.

• Storage: Store Justoza S 10/100mg Tablet in a cool, dry place, protected from direct sunlight and moisture, and out of the sight and reach of children.

JUSTOZA S 10/100MG Tablet: Frequently Asked Questions

JUSTOZA S 10/100MG Tablet, manufactured by Mankind Pharma Ltd., is a combination medication used to manage type 2 diabetes mellitus. It contains two active ingredients: Dapagliflozin (10 mg) and Sitagliptin (100 mg). This medication helps control blood sugar levels when diet and exercise alone are insufficient, and it may be used alone or in conjunction with other diabetes medications.

What is JUSTOZA S 10/100MG Tablet used for?

JUSTOZA S 10/100MG Tablet is primarily used to treat type 2 diabetes mellitus in adults. It helps to improve blood sugar control and may also reduce the risk of heart attack, heart failure, or other cardiovascular events. In some cases, it is also used to treat chronic kidney disease in adults with reduced kidney function.

How does JUSTOZA S 10/100MG Tablet work?

This medicine combines two different mechanisms to lower blood glucose. Dapagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, works by preventing the kidneys from reabsorbing glucose back into the bloodstream, leading to increased glucose excretion in the urine. Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, increases the levels of natural substances called incretins. These incretins stimulate the pancreas to produce more insulin when blood glucose levels are high and decrease the production of glucagon (a hormone that raises blood glucose), thereby reducing the amount of glucose produced by the liver.

What is the usual dosage of JUSTOZA S 10/100MG Tablet?

The recommended starting dose for a similar combination (Dapagliflozin + Sitagliptin) is often Dapagliflozin 5 mg + Sitagliptin 50 mg once daily, which may be increased to Dapagliflozin 10 mg + Sitagliptin 100 mg once daily for additional glycemic control. JUSTOZA S 10/100MG contains Dapagliflozin 10 mg and Sitagliptin 100 mg, indicating it is typically prescribed for those needing this higher dosage. It is usually taken orally once daily, with or without food. Your doctor will determine the appropriate dosage for your specific condition.

What are the possible side effects of JUSTOZA S 10/100MG Tablet?

Common side effects can include genital yeast infections, urinary tract infections (UTIs), increased urination, headache, nasopharyngitis (common cold symptoms), and diarrhea. More serious, but less common, side effects include diabetic ketoacidosis (DKA), acute pancreatitis, hypersensitivity reactions, and acute kidney injury. It's important to be aware of symptoms like severe abdominal pain, difficulty breathing, or signs of infection and seek immediate medical attention if they occur.

Is JUSTOZA S 10/100MG Tablet safe during pregnancy or breastfeeding?

JUSTOZA S 10/100MG Tablet is generally not recommended during pregnancy or breastfeeding due to limited safety data and potential risks to the developing baby. Dapagliflozin, one of the components, is not advised during the second and third trimesters of pregnancy due to potential adverse effects on fetal kidney development. For breastfeeding mothers, it is unknown how much of the medication passes into breast milk, and there's a theoretical risk to the infant's developing kidney. If you are pregnant, planning pregnancy, or breastfeeding, your doctor will need to review your treatment and may suggest alternative medications.

Can JUSTOZA S 10/100MG Tablet be taken with other medications?

Yes, JUSTOZA S 10/100MG Tablet can be used alone or with other diabetes medications, such as metformin, sulfonylureas, or insulin. However, dosage adjustments may be necessary to minimize the risk of hypoglycemia (low blood sugar) when taken with insulin or sulfonylureas. It may also interact with diuretics, potentially leading to dehydration or low blood pressure. Always inform your doctor about all medications you are taking, including over-the-counter drugs, vitamins, and herbal supplements, to avoid potential interactions.

What precautions should be taken while using JUSTOZA S 10/100MG Tablet?

Inform your doctor about any pre-existing medical conditions, especially kidney or liver disease, heart problems, or a history of pancreatitis. Maintain adequate fluid intake to prevent dehydration, especially in hot weather or during physical activity. Be aware of the symptoms of hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) and know how to treat them. If you experience persistent dizziness, joint pain, cold-like symptoms, or unexplained nausea/vomiting, inform your doctor immediately. This medication is not for type 1 diabetes mellitus.

What happens if a dose of JUSTOZA S 10/100MG Tablet is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should JUSTOZA S 10/100MG Tablet be stored?

Store the medicine in a cool and dry place, away from heat, moisture, and direct light. Keep the container tightly closed and out of the sight and reach of children. Do not store it in the bathroom.