Sorbidiol 300 Mg Tablet (10 Tab)

SORBIDIOL 300 MG TABLET

Sorbidiol 300 mg Tablet is a medication manufactured by FRANCO-INDIAN PHARMACEUTICALS PVT. LTD. commonly prescribed for various liver and gallbladder conditions.

• Composition

  • Active Ingredient: Ursodeoxycholic Acid (300 mg)

• Uses Sorbidiol 300 mg Tablet is primarily used as a hepatoprotective agent. It is prescribed for:

  • Dissolving cholesterol-rich gallstones (small cholesterol stones less than 15 mm in diameter in a functioning gallbladder).
  • Managing primary biliary cholangitis (also known as primary biliary cirrhosis), an autoimmune liver disease.
  • Treating excess cholesterol in bile.
  • Addressing biliary and liver diseases caused by cystic fibrosis in children above 6 years of age.
  • Protecting liver cells from injury caused by toxic bile acids and improving overall liver function.

• Dosage and Administration Sorbidiol 300 mg Tablet should be swallowed whole with a glass of water or milk, typically after a meal. Do not chew, crush, or break the tablet. The dosage and duration of treatment are determined by a doctor based on the patient's condition and body weight. For gallstone dissolution, an adult dosage of 6-12 mg/kg daily is often given as a single dose at bedtime or in 2-3 divided doses, continued for several months after the stones radiologically disappear. For primary biliary cirrhosis, the typical adult dose is 10-15 mg/kg daily in 2-4 divided doses. Prophylactic doses for gallstones in patients undergoing rapid weight loss can be 300 mg twice a day.

• Side Effects Common side effects may include:

  • Abdominal discomfort or pain.
  • Diarrhea or loose stools.
  • Nausea and vomiting.
  • Rash and itching.
  • Dizziness.
  • Indigestion.
  • Weakness.
  • Hair loss. Serious but rare side effects include allergic reactions, severe liver dysfunction, or worsening of bile duct obstructions.

• Precautions

  • Inform your doctor if you have allergies to ursodeoxycholic acid or any other components of the tablet.
  • Caution is advised or the medicine may be contraindicated in patients with variceal bleeding, ascites, liver encephalopathy, severe liver disease, acute inflammation of the gallbladder or biliary tract, occlusion of the biliary tract, frequent biliary colic, radio-opaque calcified gallstones, or a non-functioning gallbladder.
  • Pregnant or breastfeeding women should consult their doctor before use, as it should only be used if clearly needed.
  • Avoid alcohol consumption as it may increase drowsiness and potentially lead to liver damage.
  • This medication can interact with other drugs. Avoid taking antacids containing aluminum, cholestyramine, or colestipol without consulting a doctor, as they can reduce the effectiveness of Sorbidiol. Oral contraceptives, estrogenic hormones, and cholesterol-lowering agents like clofibrate may increase the chance of developing gallstones and can counteract the effects of Sorbidiol.
  • Regular monitoring of liver function and bilirubin levels is recommended during treatment.
  • Limited information is available for patients with kidney disease, so consultation with a doctor is advised.

• Storage Store Sorbidiol 300 mg Tablet in a cool and dry place, away from direct sunlight and moisture. Keep it out of sight and reach of children. The recommended storage temperature is below 25°C or between 10°C to 25°C / below 30°C.

What is Sorbidiol 300 MG Tablet used for?

Sorbidiol 300 MG Tablet is primarily used to dissolve certain types of gallstones that are rich in cholesterol and to manage primary biliary cirrhosis (PBC), a chronic liver disease that damages the bile ducts. It is also used to treat liver disease associated with cystic fibrosis in children aged 6 to 18 years and to prevent gallstones in overweight individuals undergoing rapid weight loss.

How does Sorbidiol 300 MG Tablet work?

Sorbidiol 300 MG Tablet contains ursodeoxycholic acid, a naturally occurring bile acid. It works by decreasing the production and absorption of cholesterol in the blood, which helps dissolve gallstones primarily composed of cholesterol. It also has a protective effect on liver cells, shielding them from injury caused by toxic bile acids and improving overall liver function. Additionally, it stimulates bile flow and bicarbonate secretion, making the bile less harmful.

What is the usual dosage for Sorbidiol 300 MG Tablet?

The dosage of Sorbidiol 300 MG Tablet is determined by your doctor based on your medical condition and body weight. It is typically taken with or after meals, often with water or milk. For gallstone dissolution, it may be prescribed as 6-12 mg/kg daily, either as a single dose at bedtime or in 2-3 divided doses. For primary biliary cirrhosis, the usual adult dosage is 10-15 mg/kg daily in 2-4 divided doses. For preventing gallstones in those losing weight rapidly, a common prophylactic dose is 300 mg twice a day. It is important to swallow the tablet whole and not to chew, crush, or break it.

What are the possible side effects of Sorbidiol 300 MG Tablet?

Common side effects of Sorbidiol 300 MG Tablet can include abdominal discomfort, abdominal pain, diarrhea or loose stools, nausea, vomiting, indigestion, rash, dizziness, headache, back pain, and hair loss. Not everyone experiences these side effects, and they are usually temporary. If any side effects persist or worsen, it's advisable to consult your doctor.

Is Sorbidiol 300 MG Tablet safe during pregnancy or breastfeeding?

During pregnancy, Sorbidiol 300 MG Tablet should be used with caution and only if clearly prescribed by your doctor, who will weigh the benefits against potential risks. For breastfeeding mothers, it should also be used with caution. Limited human data suggests that the drug does not pose a significant risk to the baby, but it's essential to consult your doctor for guidance.

Can Sorbidiol 300 MG Tablet be taken with other medications?

Sorbidiol 300 MG Tablet can interact with certain medications. For instance, antacids containing aluminum may reduce its absorption, so there should be a gap of at least 2 hours between taking them. Bile acid sequestrants like cholestyramine and colestipol can decrease the efficacy of Sorbidiol 300 MG Tablet, so it's advised to take Sorbidiol at least 1 hour before or 4-6 hours after these medicines. Immunosuppressants such as ciclosporin may have their absorption affected by ursodeoxycholic acid, leading to reduced levels. Additionally, oral contraceptives (estrogen-containing) and cholesterol-lowering agents like clofibrate may increase the risk of gallstone formation and reduce the effectiveness of Sorbidiol 300 MG Tablet. Always inform your doctor about all medicines, supplements, or herbal products you are taking.

What precautions should be taken when using Sorbidiol 300 MG Tablet?

Before taking Sorbidiol 300 MG Tablet, inform your doctor if you have allergies to its components or other bile acids, or if you have conditions like inflammation of the gallbladder or bile ducts, narrowing or blockage of bile ducts, biliary colic, calcified gallstones, or an improperly functioning gallbladder. Caution is also advised if you have liver, kidney, or gastrointestinal disorders, variceal bleeding, ascites, or liver encephalopathy. Regular monitoring of liver function and bilirubin levels may be necessary during treatment. Avoid consuming alcohol, as it could lead to increased drowsiness and liver damage. Do not discontinue the medication without consulting your doctor.

What happens if a dose of Sorbidiol 300 MG Tablet is missed?

If you miss a dose of Sorbidiol 300 MG Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should Sorbidiol 300 MG Tablet be stored?

Sorbidiol 300 MG Tablet should be stored in a cool and dry place, away from direct sunlight and moisture. Keep it out of sight and reach of children. The ideal storage temperature is generally between 10ºC to 25ºC or below 30ºC.