Dubinor D Cap

DUBINOR D Capsule

DUBINOR D Capsule, manufactured by Integrace Division, is a combination medication designed to manage various pain and mood disorders.

• Name: DUBINOR D Capsule

• Composition: Each capsule contains:

  • Pregabalin (75 mg)
  • Duloxetine (20 mg)

• Uses: DUBINOR D is prescribed for the comprehensive management of neuropathic pain and certain mental health conditions. Its uses include:

  • Management of neuropathic pain, including diabetic neuropathic pain, nerve pain caused by shingles, nerve damage, and spinal cord injuries.
  • Treatment of widespread musculoskeletal pain, such as fibromyalgia.
  • Treatment of depression and anxiety disorders.

• Dosage and Administration: Take DUBINOR D orally with or without food, as directed by your doctor. It is advisable to take the medicine at the same time each day to maintain a consistent level in the body. Swallow the capsule whole with a glass of water; do not cut, break, or chew it. Do not exceed the recommended dosage. Abruptly stopping the medication is not advised; your doctor will guide you on gradually reducing the dosage to avoid withdrawal symptoms or symptom recurrence.

• Side Effects: Common side effects may include:

  • Nausea, constipation, diarrhea.
  • Headache, dizziness, drowsiness, fatigue.
  • Dry mouth.
  • Difficulty in sleeping (insomnia).
  • Blurred vision, difficulty in concentration.
  • Increased sweating, burning sensation.
  • Loss of appetite, weight gain.
  • Peripheral edema (swelling in hands and feet).

  More serious concerns include potential for suicidal thoughts, especially when treatment begins, and the risk of liver damage from Duloxetine. Pregabalin has a potential for abuse and dependence. Consult your doctor if any side effects persist or worsen.

• Precautions:

  • Pregnancy and Breastfeeding: Use with caution. Consult your doctor if pregnant, planning pregnancy, or breastfeeding, as it may cause fetal abnormalities if taken in the last trimester.
  • Alcohol: Avoid or limit alcohol consumption as it may increase side effects like drowsiness and the risk of liver damage.
  • Children: Not recommended for use in children under 18 years of age as safety and effectiveness have not been established.
  • Elderly: Dosage adjustments may be necessary for older patients.
  • Driving/Operating Machinery: Avoid activities requiring mental alertness, such as driving or operating heavy machinery, as the medication can cause dizziness, drowsiness, and blurred vision.
  • Medical Conditions: Inform your doctor if you have kidney or liver disease, heart conditions, diabetes, fluctuating blood pressure, a history of seizures, mania, bipolar disorder, glaucoma, bleeding disorders, or are at risk of hyponatremia.
  • Drug Interactions: Inform your doctor about all other medications, supplements, or herbal products you are taking to avoid potential interactions. Avoid grapefruit or grapefruit juice, as it may increase medication levels in the bloodstream.

• Storage: Store DUBINOR D Capsule at room temperature (20-25°C or below 30°C). Protect it from moisture, light, wet surfaces, and direct sunlight. Keep the medicine out of reach of children and pets.

DUBINOR D CAP (by Integrace Division) is a combination medicine typically containing Pregabalin and Duloxetine, used primarily for managing neuropathic pain.

Here are some frequently asked questions about DUBINOR D CAP:

What is DUBINOR D CAP used for?

DUBINOR D CAP is used to treat various types of nerve pain, including diabetic neuropathic pain and fibromyalgia. It helps to manage long-lasting (chronic) pain caused by nerve damage, which can result from conditions like diabetes, shingles, or spinal cord injury.

How does DUBINOR D CAP work?

This medicine combines Pregabalin and Duloxetine. Pregabalin is an anticonvulsant that works by calming the overactive nerves in the brain, which helps to reduce nerve pain. Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) that increases the levels of chemical messengers (serotonin and norepinephrine) in the brain. These chemical messengers help regulate mood and block pain signals, thereby contributing to pain relief.

What is the usual dosage for DUBINOR D CAP?

DUBINOR D CAP should be taken exactly as advised by your doctor. It can be taken with or without food, but it's recommended to take it at the same time each day to maintain a consistent level of medicine in the body. Do not chew, crush, or break the capsule; swallow it whole with a glass of water.

What are the possible side effects of DUBINOR D CAP?

Common side effects can include nausea, constipation, headache, dry mouth, increased sweating, loss of appetite, dizziness, drowsiness, blurred vision, weight gain, and difficulty in urination. Some individuals might also experience uncoordinated body movements or tiredness. In rare cases, it can increase suicidal thoughts, so it's important to inform your doctor if you experience any unusual changes in mood or behavior.

Is DUBINOR D CAP safe during pregnancy or breastfeeding?

DUBINOR D CAP may be unsafe to use during pregnancy, especially in the last trimester, as animal studies have shown harmful effects on the developing baby and it may cause fetal abnormalities. It is generally considered unsafe or probably unsafe during breastfeeding. Always consult your doctor before using this medicine if you are pregnant, planning a pregnancy, or breastfeeding. Your doctor will weigh the potential benefits against the risks.

Can DUBINOR D CAP be taken with other medications?

It is crucial to inform your doctor about all other medicines, supplements, or herbal products you are currently taking, as DUBINOR D CAP can interact with other drugs. For instance, it has critical interactions with Tranylcypromine and Eliglustat. It can also interact with other antidepressants, opioid analgesics (like oxycodone), and certain medicines for brain-related disorders, potentially increasing drowsiness or dizziness.

What precautions should be taken while using DUBINOR D CAP?

Do not stop taking DUBINOR D CAP suddenly without your doctor's advice, as this can lead to withdrawal symptoms such as dizziness, tingling sensation, sleep disturbances, restlessness, nausea, headache, or excessive sweating. Caution is advised if you have liver or kidney disease, seizures, mania, bipolar disorder, glaucoma, bleeding disorders, or are at risk of low sodium levels. Avoid consuming alcohol, as it may enhance side effects like drowsiness and increase the risk of liver damage. It can cause dizziness and sleepiness, so avoid driving or operating machinery until you know how it affects you. It is not recommended for children under 18 years of age.

What happens if a dose of DUBINOR D CAP is missed?

If you miss a dose of DUBINOR D CAP, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should DUBINOR D CAP be stored?

DUBINOR D CAP should be stored in a cool and dry place, away from direct sunlight, moisture, and humid conditions. Keep it out of the sight and reach of children and pets. The recommended storage temperature is typically at room temperature (20-25°C) or below 30°C.