Bemezy Tab

bemEZY 180mg/10mg Tablet

bemEZY 180mg/10mg Tablet is a combination medication manufactured by USV LTD, designed to manage and reduce high cholesterol levels in the blood.

Composition

• Active Ingredients: Each tablet contains Bempedoic acid 180mg and Ezetimibe 10mg.

Uses

bemEZY 180mg/10mg Tablet is primarily used to lower high cholesterol, specifically low-density lipoprotein (LDL-C) or "bad cholesterol," and triglycerides in adults. It is prescribed for conditions such as:

• Primary hypercholesterolemia, including heterozygous familial hypercholesterolemia (HeFH).
• Mixed hyperlipidemia (elevated cholesterol and triglycerides).
• When diet and lifestyle changes alone are insufficient.
• As an additional therapy when statins alone do not adequately control cholesterol, or for statin-intolerant patients.
• Reducing the risk of cardiovascular events like heart attacks and strokes.

Dosage and Administration

Take bemEZY 180mg/10mg Tablet exactly as prescribed by your doctor.

• It can be taken with or without food.
• Swallow the tablet whole with a glass of water; do not chew, crush, or break it.
• Consistency is important; aim to take it at the same time each day to maintain a steady level of medication.
• Continue taking the medicine for the prescribed duration, even if you feel better.

Side Effects

Common side effects may include:

• Upper respiratory tract infection
• Back pain, abdominal discomfort
• Pain in extremities (arms or legs), joint pain
• Elevated liver enzymes
• Diarrhea
• Increased uric acid levels in the blood, which may lead to gout
• Headache, dizziness, unusual tiredness or weakness, nausea, cough, dry mouth, constipation, muscle spasms

Serious side effects, though rare, warrant immediate medical attention:

• Unexplained muscle pain, tenderness, or severe weakness.
• Yellowing of the skin or eyes (jaundice), dark urine, or severe stomach pain.
• Signs of an allergic reaction such as swelling or difficulty breathing.

Precautions

• Allergies: Do not take bemEZY 180mg/10mg Tablet if you are allergic to bempedoic acid, ezetimibe, or any other ingredients.
• Liver Function: Caution is advised in patients with liver problems. Your doctor may monitor liver function through blood tests before and during treatment.
• Kidney Function: Use with caution in patients with severe kidney problems.
• Pregnancy and Breastfeeding: bemEZY 180mg/10mg Tablet is generally not recommended during pregnancy or breastfeeding. Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
• Alcohol: It is advisable to limit alcohol consumption as it may increase the risk of side effects.
• Drug Interactions: Inform your doctor about all other medications, supplements, and herbal products you are taking. Interactions can occur with statins (e.g., simvastatin, atorvastatin), fibrates (e.g., fenofibrate, gemfibrozil), and bile acid sequestrants (e.g., cholestyramine, colestipol).
• Gout: Bempedoic acid can raise uric acid levels and potentially trigger gout attacks in predisposed individuals.
• Children: The safety and effectiveness of this medicine have not been established in children under 18 years of age.
• Driving: It does not typically cause drowsiness; however, if you experience dizziness or unusual tiredness, avoid driving or operating machinery.

Storage

Store bemEZY 180mg/10mg Tablet at room temperature, away from direct sunlight, heat, and moisture. Keep it out of reach and sight of children and pets.

What is BEMEZY TAB used for?

BEMEZY TAB is primarily used to manage high cholesterol levels in the blood. It is a combination medicine prescribed for adults with primary hypercholesterolaemia, including heterozygous familial hypercholesterolaemia (an inherited condition), homozygous familial hypercholesterolaemia, and mixed hyperlipidaemia (elevated cholesterol and triglycerides). It helps reduce "bad cholesterol" (LDL cholesterol) and triglycerides, especially when diet, lifestyle changes, or statins alone are not sufficient. Lowering cholesterol levels is important to reduce the risk of cardiovascular events like heart attacks and strokes.

How does BEMEZY TAB work?

BEMEZY TAB contains two active ingredients: Bempedoic acid (180 mg) and Ezetimibe (10 mg). Bempedoic acid works by inhibiting an enzyme called ATP citrate lyase in the liver, which reduces the liver's production of cholesterol and leads to increased removal of LDL cholesterol from the bloodstream. Ezetimibe acts in the small intestine, blocking the absorption of cholesterol from the diet by targeting the Niemann-Pick C1-Like 1 (NPC1L1) protein. Together, these actions reduce the overall amount of cholesterol in the body.

What is the usual dosage of BEMEZY TAB?

The daily dose of BEMEZY TAB should be taken exactly as prescribed by your doctor. The dosage can vary based on your specific condition and how your body responds to the treatment. It can be taken orally with or without food, preferably at the same time each day. It is crucial not to change your dose or stop taking the medicine without consulting your healthcare provider.

What are the possible side effects of BEMEZY TAB?

Common side effects of BEMEZY TAB may include upper respiratory tract infections, back pain, abdominal discomfort, pain in extremities (arms or legs), elevated liver enzymes, and diarrhea. Other reported side effects include headache, dizziness, constipation, dry mouth, cough, unusual tiredness or weakness, nausea, muscle spasms, and increased uric acid levels in the blood.

Serious side effects are rare but can include unexplained muscle pain, severe weakness, yellowing of the skin or eyes, dark urine, severe stomach pain, or signs of an allergic reaction (like swelling or difficulty breathing). If you experience any severe or persistent side effects, you should contact your doctor immediately.

Is BEMEZY TAB safe during pregnancy or breastfeeding?

BEMEZY TAB is generally not recommended during pregnancy as it may harm the unborn baby. Effective contraceptive methods should be used by individuals who could become pregnant while taking this medication. If pregnancy occurs during treatment, you should stop taking BEMEZY TAB and consult your doctor.

Caution is also advised while taking BEMEZY TAB if you are breastfeeding. It is unclear whether the components of this medicine pass into breast milk, and discussing potential risks and benefits with your doctor is recommended.

Can BEMEZY TAB be taken with other medications?

BEMEZY TAB can interact with other medicines. For example, when taken with statins (like atorvastatin or simvastatin), there may be an increased risk of muscle-related side effects. Fibrates (such as fenofibrate or gemfibrozil) can enhance the risk of gallstones when taken with BEMEZY TAB. Bile acid sequestrants (like cholestyramine or colestipol) should be taken at least 2 hours before or 4 hours after BEMEZY TAB. Always inform your doctor about all other medications, supplements, and herbal remedies you are taking to avoid potential interactions.

What precautions should be taken?

Several precautions should be considered:

• Allergies: Do not take BEMEZY TAB if you are allergic to bempedoic acid, ezetimibe, or any other ingredients in the medicine.
• Liver Function: Caution is advised if you have liver problems, and your doctor may recommend blood tests to monitor liver function before and during treatment.
• Kidney Function: Caution is advised if you have severe kidney problems.
• Gout: Bempedoic acid can raise uric acid levels, potentially triggering gout attacks in susceptible individuals.
• Alcohol: It is advisable to limit alcohol consumption while taking BEMEZY TAB.
• Driving/Operating Machinery: BEMEZY TAB does not typically cause drowsiness or affect alertness, so you may continue driving and using machines unless you experience dizziness.

What happens if a dose is missed?

If you miss a dose of BEMEZY TAB, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

How should it be stored?

BEMEZY TAB should be stored in a cool and dry place, away from direct sunlight, heat, and moisture. It should be kept out of the reach and sight of children, typically below 30°C.