Piokind M 15 Mg Tablet (10 Tab)

PIOKIND M 15 MG TABLET

PIOKIND M 15 MG TABLET, manufactured by Mankind Pharma Ltd., is a combination medicine prescribed for the management of type 2 diabetes mellitus in adults.

Composition Each tablet contains:

• Pioglitazone: 15 mg
• Metformin: 500 mg

Uses PIOKIND M 15 MG TABLET is primarily used for the treatment of type 2 diabetes mellitus. It is indicated when diet, exercise, and therapy with other single agents do not result in adequate glycemic control. This medication works to lower blood sugar levels, improve the body's sensitivity to insulin, and decrease glucose production in the liver. It can also help control intestinal glucose absorption.

Dosage and Administration The recommended dosage is individualized based on blood sugar levels, response to treatment, and other medications being taken. Typically, PIOKIND M 15 MG TABLET is taken orally once or twice daily with meals to minimize gastrointestinal side effects. It is crucial to adhere strictly to the doctor's instructions regarding dosage and timing, taking the tablet whole with water.

Side Effects Common side effects may include:

• Upper respiratory tract infection
• Headache
• Muscle pain (arthralgia)
• Edema (swelling)
• Weight gain
• Nausea, vomiting, diarrhea, stomach pain, loss of appetite, and metallic taste

Serious side effects, though less common, can include lactic acidosis, liver problems (e.g., yellowing of skin or eyes, dark urine), heart failure, and bone fractures.

Precautions

• Contraindications: This medication is contraindicated in patients with severe kidney disease, liver disease, active bladder cancer or a history of bladder cancer, and heart failure. It is also not recommended for pregnant or breastfeeding women, or in children and adolescents under 18 years.
• Alcohol: Avoid excessive alcohol consumption as it may increase the risk of hypoglycemia and lactic acidosis.
• Monitoring: Regular monitoring of blood sugar levels and liver function is important.
• Drug Interactions: Inform your doctor about all other medications, supplements, and herbal products you are taking, especially other antidiabetic medicines, NSAIDs, corticosteroids, gemfibrozil, and rifampicin.
• Elderly Patients: Use with caution in elderly patients (aged 65 years or older) due to increased risk of bladder cancer, heart failure, and bone fracture.

Storage Store in a cool and dry place, away from sunlight. Keep out of sight and reach of children. The medicine should be stored below 30°C.

What is PIOKIND M 15 MG TABLET used for?

PIOKIND M 15 MG TABLET is primarily used in adults for the management of type 2 diabetes mellitus. It helps to improve blood sugar control when diet and exercise alone are not sufficient, or when metformin alone is not effective enough. It works to lower high blood sugar levels and enhance the body's sensitivity to insulin.

How does PIOKIND M 15 MG TABLET work?

This medicine is a combination of two active ingredients: Pioglitazone and Metformin. Pioglitazone, a thiazolidinedione, increases the body's sensitivity to insulin in peripheral tissues like muscles, fat, and the liver, allowing cells to utilize glucose more effectively. Metformin, a biguanide, primarily works by reducing the amount of glucose produced by the liver and improving the body's response to insulin, while also slowing down glucose absorption from the intestine.

What is the usual dosage for PIOKIND M 15 MG TABLET?

The dosage of PIOKIND M 15 MG TABLET is individualized by your doctor based on your blood sugar levels, response to treatment, and other medications you may be taking. It is typically taken once or twice daily with meals to minimize gastrointestinal side effects. It is important to take this medication regularly and at the same time(s) each day to maintain consistent blood sugar levels.

What are the possible side effects of PIOKIND M 15 MG TABLET?

Common side effects can include upper respiratory tract infection, headache, muscle pain, edema (swelling), weight gain, nausea, vomiting, diarrhea, stomach pain, loss of appetite, and a metallic taste. Hypoglycemia (low blood sugar) is also a possible side effect, especially when taken with other antidiabetic medicines. More serious but less common side effects can involve liver problems, heart failure, and an increased risk of bone fractures (especially in women). A rare but serious condition called lactic acidosis may also occur.

Is PIOKIND M 15 MG TABLET safe during pregnancy or breastfeeding?

PIOKIND M 15 MG TABLET is generally not recommended for use during pregnancy as it may pose risks to the unborn baby. It is also advised to use caution or avoid this medication while breastfeeding, as its ingredients may pass into breast milk. Always consult your doctor if you are pregnant, planning to conceive, or breastfeeding.

Can PIOKIND M 15 MG TABLET be taken with other medications?

Yes, but it's important to inform your doctor about all medications, supplements, and herbal products you are currently taking, as PIOKIND M 15 MG TABLET can interact with several drugs. These include other antidiabetic agents (e.g., insulin), certain heart medications, pain relievers (NSAIDs), thyroid hormones, antacids, and medications eliminated by the kidneys. Interactions can affect the efficacy of PIOKIND M or increase the risk of side effects.

What precautions should be taken while taking PIOKIND M 15 MG TABLET?

Several precautions should be observed:

• Kidney, Liver, or Heart Conditions: PIOKIND M 15 MG TABLET is contraindicated in severe kidney disease, liver disease, or heart failure (especially NYHA Class III or IV). It should be used with caution in patients with mild to moderate conditions, and regular monitoring of organ function may be required.
• Alcohol Consumption: Avoid or limit alcohol intake as it can increase the risk of low blood sugar and a serious condition called lactic acidosis.
• Bone Fractures: There is an increased risk of bone fractures, particularly in women, with pioglitazone-containing medicines.
• Macular Edema: Use with caution if you have a history of macular edema (a type of diabetic eye disease).
• Type 1 Diabetes or Diabetic Ketoacidosis: This medication is not suitable for individuals with type 1 diabetes or diabetic ketoacidosis.
• Children and Elderly: It is not recommended for use in children and adolescents under 18 years of age. Elderly patients should use it with caution due to increased susceptibility to side effects.

What happens if a dose of PIOKIND M 15 MG TABLET is missed?

If you miss a dose of PIOKIND M 15 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should PIOKIND M 15 MG TABLET be stored?

PIOKIND M 15 MG TABLET should be stored in a cool and dry place, typically below 30°C, away from direct sunlight and moisture. Keep it out of sight and reach of children.