Akt 2 Kit

AKT 2 KIT (Lupin Ltd.)

AKT 2 KIT, also commonly known as AKT 2 Tablet, is a combination medication manufactured by Lupin Ltd., primarily used in the treatment of tuberculosis.

• Composition: Each AKT 2 KIT tablet typically contains two active ingredients:

  • Isoniazid (INH) 300 MG
  • Rifampicin 450 MG These antibiotics work synergistically: Rifampicin inactivates a bacterial enzyme (RNA-polymerase) essential for protein synthesis and reproduction, while Isoniazid prevents the tuberculosis-causing bacteria from forming their protective covering. Together, they kill the bacteria and eradicate the infection.

• Uses: AKT 2 KIT is primarily prescribed for the treatment of tuberculosis (TB), a highly infectious disease that mainly affects the lungs but can also impact other parts of the body (extra-pulmonary tuberculosis). It may also be used to manage bacterial infections of membranes covering the brain and spinal cord, and certain contagious diseases affecting the skin, nerves, and mucous membranes. This medication is usually taken in combination with other anti-tubercular drugs to prevent the spread of infection and reduce the risk of drug resistance.

• Dosage and Administration: AKT 2 KIT is a prescription medication and should be taken exactly as advised by a doctor. It is typically taken once daily on an empty stomach, preferably in the morning, about one hour before or two hours after a meal, as food can decrease the absorption of Rifampicin. The course of treatment, often lasting around 4 months, must be completed even if symptoms improve, to prevent relapse or drug resistance.

• Side Effects: Common side effects can include nausea, vomiting, fever, dark-colored urine, sweating, increased saliva, abdominal pain, skin rash, itching, dizziness, lethargy, peripheral neuropathy (tingling and numbness of feet and hands), and increased liver enzymes. More serious, though rare, side effects may involve jaundice, hepatitis, low blood platelets, vision or hearing loss, and severe allergic reactions (e.g., rashes, swelling, shortness of breath). This medicine can also cause reddish-orange discoloration of urine, sweat, saliva, and tears, which is normal and not harmful.

• Precautions:

  • Alcohol: Avoid consuming alcohol as it can increase the risk of side effects, particularly liver damage.
  • Liver/Kidney Disease: Patients with pre-existing liver or kidney conditions should use this medicine with caution and under strict medical supervision.
  • Pregnancy/Breastfeeding: Consult a doctor if pregnant, breastfeeding, or planning a pregnancy, as it may be unsafe or require careful consideration.
  • Drug Interactions: Inform your doctor about all medications, including over-the-counter drugs and supplements, as AKT 2 KIT can interact with various medicines, including oral contraceptives, making them less effective.
  • Food Interactions: Avoid tyramine-rich foods (e.g., cheese, smoked fish, certain meats, some beers) while taking AKT 2 KIT.
  • Diabetes and Peripheral Neuropathy: Caution is advised for patients with diabetes or peripheral neuropathy.

• Storage: Store AKT 2 KIT tablets below 30°C or at room temperature, according to the instructions on the pack. Keep the medicine in its original container, tightly closed, and away from pets and children.

AKT 2 KIT, manufactured by Lupin Ltd., is a combination medication primarily used in the treatment of tuberculosis (TB). It contains Rifampicin and Isoniazid, two potent antitubercular agents.

What is AKT 2 KIT used for?

AKT 2 KIT is primarily used for the treatment of tuberculosis (TB), which is a bacterial infection mainly affecting the lungs but can also impact other parts of the body. It helps to treat both pulmonary (within the lung) and extra-pulmonary (outside the lung) tuberculosis.

How does AKT 2 KIT work?

AKT 2 KIT contains two active ingredients: Rifampicin and Isoniazid. Rifampicin works by blocking the action of a bacterial enzyme (RNA-polymerase) necessary for the tuberculosis bacteria to multiply and make essential proteins. Isoniazid prevents the tuberculosis-causing bacteria from forming their protective covering. Together, these actions kill the bacteria and stop the infection from spreading.

What is the usual dosage and how should it be taken?

The dosage of AKT 2 KIT is determined by your doctor based on your age, body weight, and specific disease condition. It should be taken on an empty stomach, at least 1-2 hours before or after a meal, as food can decrease the absorption of Rifampicin. It is crucial to swallow the tablet whole with water and not to chew, crush, or break it. Take it at the same time every day to maintain a consistent level of medicine in the body.

What are the possible side effects of AKT 2 KIT?

Common side effects of AKT 2 KIT include nausea, vomiting, heartburn, headache, bloating, and dark-colored urine. Other reported side effects include increased menstrual flow, tingling or numbness in the hands and feet, skin rash, yellowing of the skin and eyes, and flu-like syndrome. More serious but rare side effects can include severe thrombocytopenia (low platelet count), loss of vision or hearing, and joint stiffness (arthralgia). Rifampicin can also cause discoloration (yellow, orange, red, brown) of teeth, urine, sweat, sputum, and tears, which is normal and not harmful.

Is AKT 2 KIT safe during pregnancy or breastfeeding?

AKT 2 KIT should be used with caution during pregnancy and in women planning for pregnancy. It is recommended to consult your doctor before taking this medicine if you are pregnant or breastfeeding. The medicine may pass into breast milk, and potential benefits must outweigh the risks.

Can AKT 2 KIT be taken with other medications?

AKT 2 KIT can interact with several other medications. It can reduce the effectiveness of oral contraceptives, so alternative birth control methods should be used. It may also interact with antiviral medications, antifungals (like ketoconazole), anticonvulsants, benzodiazepines, warfarin, antacids, and corticosteroids, potentially decreasing their efficacy or increasing side effects. Always inform your doctor about all other medications you are taking.

What precautions should be taken while using AKT 2 KIT?

Caution should be exercised if you have liver or kidney conditions, diabetes, colitis, hematopoietic disturbances, or porphyria. Alcohol consumption should be avoided as it can increase the risk of side effects, particularly liver issues and excessive drowsiness. The medication is not recommended for children below 15 years of age due to lack of safety and efficacy data. Avoid taking indigestion remedies (antacids) within at least two hours of taking AKT 2 KIT.

What happens if a dose of AKT 2 KIT is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this can be dangerous. It is important to complete the full course of treatment even if you feel better, as stopping early can lead to the infection reappearing or becoming drug-resistant.

How should it be stored?

AKT 2 KIT should be stored at room temperature, ideally between 20-30 degrees Celsius. Keep it in its original container, tightly closed, and out of reach of children. Dispose of any unused medicine safely.