Istavel D 5/100 Mg

ISTAVEL D 5/100 MG

ISTAVEL D 5/100 MG is a medication manufactured by SUN PHARMA LABORATORIES LTD., used for the management of type 2 diabetes mellitus.

Composition

ISTAVEL D 5/100 MG contains two active ingredients:

• Dapagliflozin (5 mg): This is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It works by blocking the reabsorption of glucose in the kidneys, leading to increased glucose excretion in the urine and thus lowering blood sugar levels.
• Sitagliptin (100 mg): This is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It increases the release of insulin from the pancreas and decreases the secretion of glucagon (a hormone that raises blood sugar), thereby reducing the amount of glucose produced by the liver.

Uses

ISTAVEL D 5/100 MG is prescribed for:

• Treating type 2 diabetes mellitus in adults, especially when diet and exercise alone are not sufficient to control blood sugar levels.
• Improving glycemic control and preventing serious complications associated with diabetes, such as eyesight loss, kidney damage, and nerve damage.
• Treating chronic kidney disease in adults with reduced kidney function, helping to protect kidneys from losing their function.

Dosage and Administration

This medication is typically taken orally once daily, preferably in the morning, with or without food. It is crucial to follow the doctor's instructions carefully and not to change the dosage without consulting them. Taking it at the same time each day is recommended for optimal benefits. Do not crush, break, or chew the tablet.

Side Effects

Common side effects may include:

• Diarrhea, nausea, vomiting, headache, dizziness.
• Urinary tract infections (UTIs) and genital yeast infections.
• Increased urination.
• Upper respiratory tract infections, nasal congestion, sore throat.
• Joint pain (arthralgia).

Serious side effects, though less common, can include:

• Hypoglycemia (low blood sugar), especially when used with insulin or sulphonylureas.
• Allergic reactions (rash, hives, swelling of the face, lips, tongue, or throat).
• Inflamed pancreas (pancreatitis).
• Kidney or liver problems.

Precautions

• Pregnancy and Breastfeeding: Caution is advised. It may not be recommended during pregnancy or breastfeeding, and a doctor should be consulted.
• Kidney and Liver Conditions: Not recommended for severe kidney problems or those on dialysis. Caution is advised for mild to moderate liver issues. Kidney function may be monitored.
• Alcohol: Limit alcohol consumption as it can affect blood sugar levels.
• Elderly Patients: Special caution may be needed as they might be more prone to side effects.
• Driving and Operating Machinery: May cause dizziness or low blood sugar; caution is advised until you know how the medication affects you.
• Drug Interactions: Inform your doctor about all other medications, especially insulin, insulin secretagogues, diuretics (e.g., furosemide), and rifampin, as interactions can occur.
• Do not stop taking the medicine abruptly, as this can increase blood sugar levels and the risk of complications.

Storage

Store ISTAVEL D 5/100 MG in a cool and dry place, away from direct sunlight, at room temperature between 20-25°C or below 30°C. Keep it out of sight and reach of children and pets.

Here are the most frequently asked questions about ISTAVEL D 5/100 MG by SUN PHARMA LABORATORIES LTD., along with concise answers:

What is ISTAVEL D 5/100 MG used for?

ISTAVEL D 5/100 MG is a combination medicine primarily used to treat type 2 diabetes mellitus in adults. It helps control high blood sugar levels when diet and exercise alone are not sufficient, or when metformin is not appropriate. It aims to improve overall blood sugar control and prevent diabetic complications.

How does ISTAVEL D 5/100 MG work?

This medication contains two active ingredients: Sitagliptin and Dapagliflozin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that works by increasing the release of insulin from the pancreas and decreasing the secretion of glucagon, a hormone that raises blood sugar. Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that works by blocking the reabsorption of glucose in the kidneys, causing excess glucose to be excreted in the urine. This dual action helps effectively lower blood sugar levels.

What is the usual dosage for ISTAVEL D 5/100 MG?

ISTAVEL D 5/100 MG is usually taken once daily, preferably in the morning, with or without food. The exact dosage is determined by your doctor based on individual needs and response to treatment, and it's crucial not to change the dosage without consulting them.

What are the possible side effects of ISTAVEL D 5/100 MG?

Common side effects may include urinary tract infections, yeast infections (genital fungal infections), increased urination, headache, dizziness, nausea, vomiting, diarrhea, abdominal pain, and upper respiratory tract infections. Less common but potentially serious side effects can involve allergic reactions, liver or kidney problems, and changes in blood sugar levels.

Is ISTAVEL D 5/100 MG safe during pregnancy or breastfeeding?

The safety of ISTAVEL D 5/100 MG during pregnancy has not been established, and it is generally not recommended for use in pregnant women. Similarly, it is not known whether it passes into breast milk, so it is not recommended for use during breastfeeding. Always consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Can ISTAVEL D 5/100 MG be taken with other medications?

ISTAVEL D 5/100 MG can interact with certain medications. Inform your doctor about all other medicines, including prescription drugs, over-the-counter medications, and herbal supplements you are taking. Particular care should be taken if you are using insulin or other anti-diabetic drugs, diuretics, certain anti-fungal medications (like ketoconazole), or anti-viral agents (like ritonavir), as interactions may occur.

What precautions should be taken while using ISTAVEL D 5/100 MG?

Precautions include informing your doctor if you have kidney or liver problems, heart disease, or a history of pancreatitis. You should also be cautious if you are prone to urinary tract infections. It's important to maintain a healthy diet and regular exercise, and to drink plenty of fluids to prevent dehydration. Alcohol consumption should be limited as it may affect blood sugar levels.

What happens if a dose of ISTAVEL D 5/100 MG is missed?

If you miss a dose of ISTAVEL D 5/100 MG, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should ISTAVEL D 5/100 MG be stored?

ISTAVEL D 5/100 MG should be stored in a cool, dry place, typically between 20-25°C or below 30°C, away from direct sunlight and moisture. Keep it out of reach of children and pets.