Daparyl V 5/100 Mg Tablet (10 Tab)

DAPARYL V 5/100 MG TABLET

DAPARYL V 5/100 MG TABLET is an oral antidiabetic medication manufactured by Intas Pharmaceuticals Ltd., designed for adults with Type 2 Diabetes Mellitus.

Composition Each tablet contains:

• Dapagliflozin: 5 mg (a sodium-glucose cotransporter-2 (SGLT2) inhibitor)
• Vildagliptin: 100 mg (a dipeptidyl peptidase-4 (DPP-4) inhibitor)

Uses DAPARYL V 5/100 MG TABLET is prescribed to manage blood sugar levels in adults with Type 2 Diabetes Mellitus, especially when diet and exercise alone are insufficient, or when metformin monotherapy is poorly controlled. It helps improve glycemic control by enhancing insulin release, reducing glucagon, and increasing the excretion of glucose through urine. This medication also contributes to reducing the risk of diabetes-related complications, including nerve damage, kidney problems, vision loss, and cardiovascular events.

Dosage and Administration This medication should be taken as directed by a healthcare professional. It can be taken with or without food, preferably at the same time each day to maintain consistent blood levels. Tablets should be swallowed whole with a glass of water; they should not be crushed, broken, or chewed.

Side Effects Common side effects may include headache, dizziness, nausea, vomiting, abdominal pain, frequent urination, urinary tract infections, and genital yeast infections (in males and females). Other common side effects can include back pain, rash, changes in blood cholesterol or fat levels, and nasopharyngitis. Serious, but less common, side effects requiring immediate medical attention include angioedema (swelling of face, throat, or tongue), liver inflammation (jaundice, dark urine), and pancreatitis (severe stomach pain).

Precautions Inform your doctor about any pre-existing medical conditions, especially kidney or liver disease, heart problems, hypertension, or a history of urinary tract infections. Caution is advised for pregnant or breastfeeding women. Alcohol consumption should be avoided as it may increase the risk of hypoglycemia and lactic acidosis. This medicine may cause dizziness, so exercise caution when driving or operating machinery. Interactions may occur with other antidiabetic medicines, diuretics, corticosteroids, and certain anticonvulsants.

Storage Store DAPARYL V 5/100 MG TABLET in a cool and dry place, below 30°C, away from direct light and heat. Keep out of the sight and reach of children.

What is DAPARYL V 5/100 MG Tablet used for?

DAPARYL V 5/100 MG Tablet is an anti-diabetic medication primarily used to manage blood sugar levels in adults with Type 2 Diabetes Mellitus. It is typically prescribed when diet and exercise alone are not sufficient to control blood sugar, or when metformin monotherapy is not adequately controlling blood sugar. This medicine helps to improve glycemic control and can also aid in reducing the risk of cardiovascular events and worsening kidney disease associated with long-term uncontrolled diabetes.

How does DAPARYL V 5/100 MG Tablet work?

DAPARYL V 5/100 MG Tablet is a combination of two active ingredients: Dapagliflozin (5 mg) and Vildagliptin (100 mg).

• Dapagliflozin is a sodium-glucose cotransporter-2 (SGLT2) inhibitor. It works by preventing the kidneys from reabsorbing glucose back into the bloodstream, leading to increased excretion of excess glucose through urine. This process helps lower blood sugar levels and may also contribute to modest weight loss and blood pressure reduction.
• Vildagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It enhances the body's natural incretin hormones, which stimulate the release of insulin after meals and reduce the production of glucagon (a hormone that raises blood sugar) by the liver. This dual action helps stabilize blood sugar levels after eating and throughout the day.

Together, these two components provide a comprehensive approach to managing Type 2 Diabetes Mellitus by targeting different pathways involved in glucose regulation.

What is the usual dosage of DAPARYL V 5/100 MG Tablet?

The dosage of DAPARYL V 5/100 MG Tablet is determined by your doctor, based on your individual health condition and response to the medication. It is typically taken orally once or twice daily. The tablet should be swallowed whole with a glass of water, and it can be taken with or without food. It is recommended to take the medicine at the same time each day to maintain consistent blood levels and ensure optimal effectiveness. Do not crush, chew, or break the tablet unless specifically instructed by your healthcare provider. It is crucial not to exceed the prescribed dose or stop taking the medicine without consulting your doctor.

What are the possible side effects of DAPARYL V 5/100 MG Tablet?

Common side effects of DAPARYL V 5/100 MG Tablet may include:

• Genital fungal infections (e.g., vaginal yeast infections or balanitis)
• Urinary tract infections (UTIs)
• Frequent or increased urination
• Headache
• Nausea, vomiting, diarrhea, or abdominal pain
• Dizziness or tremors
• Back pain
• Upper respiratory tract infection (e.g., common cold or nasopharyngitis)
• Changes in blood cholesterol or fat levels (dyslipidemia)
• Increased amount of red blood cells (hematocrit)

Serious but less common side effects can include severe abdominal pain (possibly indicating pancreatitis), liver inflammation, or allergic reactions like angioedema (swelling of the face, throat, or tongue). If any side effects persist, worsen, or if you experience any severe symptoms, contact your doctor immediately.

Is DAPARYL V 5/100 MG Tablet safe during pregnancy or breastfeeding?

DAPARYL V 5/100 MG Tablet is generally not recommended during pregnancy or while breastfeeding. There is limited information on its use in pregnant women, and moderate side effects have been reported. It is also not known if the active ingredients pass into breast milk. If you are pregnant, planning to become pregnant, or breastfeeding, it is crucial to consult your doctor to discuss the risks and alternatives. Your doctor will weigh the benefits against the potential risks and prescribe an appropriate course of action for managing your blood sugar.

Can DAPARYL V 5/100 MG Tablet be taken with other medications?

DAPARYL V 5/100 MG Tablet can interact with other medications, potentially affecting its efficacy or increasing the risk of side effects. It is essential to inform your doctor about all other medicines you are currently taking, including over-the-counter drugs, herbal supplements, and vitamins.

Potential interactions include:

• Other blood sugar-lowering medicines (e.g., glimepiride, glipizide, insulin, or sulphonylureas): Concurrent use can increase the risk of hypoglycemia (low blood sugar).
• Diuretics (water pills) (e.g., furosemide, hydrochlorothiazide, methyclothiazide, trichlormethiazide): Taking these with Daparyl V can increase the risk of dehydration and low blood pressure due to increased urinary glucose excretion.
• Corticosteroids (e.g., prednisolone, hydrocortisone): These can affect blood sugar levels, requiring dose adjustments.
• Medicines for fits (e.g., phenytoin, phenobarbital).
• Medicines for underactive thyroid (e.g., levothyroxine, liothyronine).
• ACE inhibitors: May increase the risk of angioedema.

Your doctor will assess your complete medication list to avoid potential drug interactions and ensure safe and effective treatment.

What precautions should be taken while using DAPARYL V 5/100 MG Tablet?

Several precautions should be taken while using DAPARYL V 5/100 MG Tablet:

• Kidney and Liver Conditions: Inform your doctor if you have any pre-existing kidney or liver disease, as the dosage may need adjustment, or an alternative medicine might be prescribed. The medicine is not recommended for severe kidney impairment.
• Heart Problems: Caution is advised if you have heart problems or hypertension.
• Urinary Tract Infections: Inform your doctor if you have a history of urinary tract infections, as Dapagliflozin can increase the risk.
• Pancreatitis: Patients with a history of pancreatitis should exercise caution as vildagliptin could potentially exacerbate the condition.
• Alcohol Consumption: Avoid excessive alcohol intake as it increases the risk of hypoglycemia (low blood sugar) and lactic acidosis.
• Driving and Operating Machinery: This medicine may cause dizziness and drowsiness. Avoid driving or operating machinery if you experience these symptoms.
• Hydration and Hygiene: Stay well-hydrated to prevent dehydration and maintain good personal hygiene to reduce the risk of genital fungal infections.
• Children: The medicine is not recommended for children as its safety and effectiveness have not been established.
• Allergies: Do not take this medicine if you are allergic to dapagliflozin, vildagliptin, or any other components of the tablet.

Always follow your doctor's instructions and attend regular check-ups to monitor your blood sugar levels and overall health.

What happens if a dose of DAPARYL V 5/100 MG Tablet is missed?

If you miss a dose of DAPARYL V 5/100 MG Tablet, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this could lead to an overdose or increased side effects. Consistently taking your medication as prescribed is important for effective blood sugar control.

How should DAPARYL V 5/100 MG Tablet be stored?

DAPARYL V 5/100 MG Tablet should be stored in a cool and dry place, away from direct sunlight and moisture. The temperature should ideally be below 30°C. Keep the medicine out of the sight and reach of children and pets. Proper storage helps maintain the effectiveness of the medication.