Triolmezest Tablet (10 Tab)

TRIOLMEZEST TABLET is a combination medication manufactured by SUN PHARMA LABORATORIES LTD., primarily prescribed for the management of hypertension (high blood pressure). This medicine works by relaxing blood vessels, improving blood flow, and reducing excess fluid in the body, thereby lowering blood pressure and reducing the risk of heart attacks and strokes.

Composition

Each tablet contains a combination of three active ingredients:

• Olmesartan Medoxomil: 20 mg
• Amlodipine: 5 mg
• Hydrochlorothiazide: 12.5 mg

Olmesartan is an angiotensin II receptor blocker (ARB) that helps relax and widen narrowed blood vessels. Amlodipine is a calcium channel blocker that reduces the heart's workload and enhances its efficiency in pumping blood. Hydrochlorothiazide is a diuretic that helps remove extra water and certain electrolytes from the body.

Uses

TRIOLMEZEST TABLET is used for:

• Lowering high blood pressure (hypertension).
• Reducing the risk of cardiovascular complications such as heart attack and stroke.
• Preventing kidney damage associated with high blood pressure.

Dosage and Administration

The medication should be taken as directed by a physician. The usual dose is one tablet per day, which can be taken with or without food. It is important to take it at the same time each day to maintain a consistent level in the blood. Do not discontinue the medicine without consulting your doctor, as this can cause blood pressure to rise.

Side Effects

Common side effects include:

• Nausea, upset stomach, diarrhea
• Headache, dizziness, fatigue, sleepiness
• Swelling of ankles or feet (peripheral edema)
• Dehydration, electrolyte imbalance, increased urination
• Muscle cramps, joint pain
• Decreased blood pressure (hypotension)

Serious side effects, though rare, can include severe allergic reactions, skeletal muscle problems leading to kidney failure, and inflammation of the pancreas.

Precautions

• Pregnancy and Breastfeeding: TRIOLMEZEST TABLET is not recommended during pregnancy as it may harm the fetus. It is also advised against during breastfeeding as its effect on the baby is unknown.
• Medical Conditions: Inform your doctor if you have kidney or liver problems, diabetes, low blood pressure, or are severely dehydrated.
• Drug Interactions: Avoid taking with aliskiren if you have diabetes. Inform your doctor about all other medications, supplements, and herbal tonics you are taking to avoid potential interactions, including certain antibiotics, HIV medications, antifungals, and heart medications.
• Alcohol: Alcohol consumption should be avoided as it may increase the risk of side effects like drowsiness and dizziness.
• Diet: Avoid potassium-rich foods and supplements. Limit salt intake and stay well-hydrated.
• Driving: This medicine may cause dizziness or drowsiness; exercise caution when driving or operating machinery.

Storage

TRIOLMEZEST TABLET should be stored at room temperature, away from heat and direct light, and protected from moisture. Keep it out of reach of children and pets.

Here are some frequently asked questions about TRIOLMEZEST TABLET:

What is Triolmezest Tablet used for?

Triolmezest Tablet is a combination medication primarily used to manage hypertension, also known as high blood pressure. It is typically prescribed when a single medication is not effective in controlling blood pressure. By lowering high blood pressure, it helps reduce the risk of serious complications such as heart attacks, strokes, and kidney damage.

How does Triolmezest Tablet work?

Triolmezest Tablet contains three active ingredients: Olmesartan medoxomil, Amlodipine besilate, and Hydrochlorothiazide.

• Olmesartan medoxomil is an angiotensin II receptor blocker (ARB) that works by blocking the action of a hormone called angiotensin II, which helps relax and widen blood vessels, improving blood flow.
• Amlodipine besilate is a calcium channel blocker that relaxes and widens blood vessels, allowing blood to flow more easily and reducing the workload on the heart.
• Hydrochlorothiazide is a diuretic (often called a "water pill") that increases urine production, helping to remove excess fluid, sodium, and certain electrolytes from the body. This reduces blood volume and further lowers blood pressure. Together, these ingredients work through different mechanisms to effectively lower blood pressure.

What is the usual dosage of Triolmezest Tablet?

The usual dose of Triolmezest Tablet is typically one tablet per day, taken as directed by your doctor. It can be taken with or without food. Your doctor will determine the correct dosage and duration of treatment based on your specific health condition, age, and response to the medication. It is important to swallow the tablet whole with water and not crush or chew it.

What are the possible side effects of Triolmezest Tablet?

Some common side effects of Triolmezest Tablet include dizziness, headache, tiredness, nausea, upset stomach, diarrhea, electrolyte imbalance, swollen ankles or feet, and increased urination. In some cases, it may cause low blood pressure. Most of these side effects are usually temporary and resolve over time. However, if any side effects are persistent or worsen, you should contact your doctor. More serious, though rare, side effects can include severe allergic reactions (such as swelling of the face, lips, or throat), severe skin reactions, chest pain, or inflammation of the pancreas.

Is Triolmezest Tablet safe during pregnancy or breastfeeding?

Triolmezest Tablet is generally not recommended for use during pregnancy as it may cause harm to the developing baby. If you become pregnant while taking this medication, you should inform your doctor immediately. Similarly, it is usually not recommended during breastfeeding because components of the tablet may pass into breast milk, and its effect on the nursing baby is unknown or potentially harmful. Your doctor may suggest an alternative.

Can Triolmezest Tablet be taken with other medications?

Triolmezest Tablet can interact with various other medications. It is crucial to inform your doctor about all prescription drugs, over-the-counter medicines, supplements, and herbal preparations you are currently taking to avoid potential interactions. Some medications that may interact with Triolmezest Tablet include:

• Other blood pressure-lowering medications (e.g., aliskiren, ACE inhibitors like ramipril or lisinopril), which can lead to a significant drop in blood pressure and increased risk of side effects, especially in patients with diabetes or kidney problems.
• Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, which can decrease the effectiveness of Triolmezest Tablet and increase the risk of kidney damage.
• Lithium (used for psychiatric illness), as Triolmezest can increase blood lithium levels, leading to toxicity.
• Potassium-sparing diuretics or potassium supplements, as this medicine already contains hydrochlorothiazide, which can affect potassium levels.
• Certain antibiotics (e.g., erythromycin, clarithromycin), HIV medications (ritonavir), antifungals (ketoconazole, itraconazole), and heart medications (diltiazem, verapamil). Avoid consuming grapefruit or grapefruit juice while on this medication, as it may severely decrease your blood pressure.

What precautions should be taken?

Before taking Triolmezest Tablet, inform your doctor if you have any existing medical conditions, especially heart problems (e.g., heart failure, irregular heartbeat), liver disease, kidney disease (including severe kidney impairment or kidney transplant), diabetes, low blood pressure (hypotension), or severe dehydration due to vomiting or diarrhea.

• Regular monitoring of blood pressure, kidney function, electrolyte levels, and blood sugar levels may be necessary during treatment.
• Avoid consuming alcohol while taking this medicine as it can increase the risk of side effects like dizziness and further lower blood pressure.
• This medicine may cause dizziness or drowsiness, so avoid driving or operating heavy machinery until you know how it affects you.
• Do not stop taking the medication abruptly without consulting your doctor, as this can cause your blood pressure to rise and increase the risk of heart attack or stroke.

What happens if a dose is missed?

If you miss a dose of Triolmezest Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should it be stored?

Triolmezest Tablet should be stored in a cool, dry place, protected from direct sunlight, moisture, and heat. Keep the medicine out of reach of children and pets. Ensure the container is tightly closed.

How long does Triolmezest Tablet take to start working?

While Triolmezest Tablet may show a noticeable reduction in blood pressure within about 2 weeks, it can take approximately 8 weeks to experience the full benefits of the medication. It's important to continue taking it regularly as prescribed, even if you feel well, as high blood pressure often has no symptoms.