Sacurise 50 Mg Tablet (14 Tab)

SACURISE 50 MG TABLET is a medication used in the management of chronic heart failure.

Name

• Brand Name: SACURISE 50 MG TABLET
• Common Name: Sacubitril/Valsartan

Composition

Each tablet contains two active ingredients:

• Sacubitril (24 mg)
• Valsartan (26 mg) This combination is classified as an Angiotensin Receptor Neprilysin Inhibitor (ARNI).

Uses

SACURISE 50 MG TABLET is primarily used to manage chronic heart failure with reduced ejection fraction (HFrEF) in adults. It helps relax blood vessels, reduce fluid retention, and decrease the heart's workload, thereby improving heart function and reducing the risk of cardiovascular death and hospitalization. It may also be used for children aged 1 to 18 with heart failure.

Dosage and Administration

• Swallow the tablet whole with a glass of water. Do not crush, chew, or split the tablet.
• It can be taken with or without food.
• Always take this medicine as directed by your doctor. Your physician will determine the dose and duration of treatment based on your medical condition.

Side Effects

Common Side Effects:

• Low blood pressure (hypotension), which may cause dizziness or light-headedness.
• High potassium levels (hyperkalemia).
• Cough.
• Dizziness.
• Kidney problems or renal impairment.
• Nausea, diarrhea, and weakness.
• Headache, tiredness, or fatigue.

Serious Side Effects:

• Angioedema (swelling of the face, lips, tongue, or throat, which can cause breathing difficulties). Seek immediate medical attention if this occurs.

Precautions

• Allergy: Do not take if you are allergic to sacubitril, valsartan, or any other ingredients in the medicine.
• Angioedema History: Avoid if you have a history of angioedema related to ACE inhibitor or ARB use.
• Pregnancy and Breastfeeding: Not recommended for use during pregnancy as it can harm the unborn baby. It is also not recommended for breastfeeding women.
• Drug Interactions:
  • Do not take with ACE inhibitors (e.g., captopril, enalapril) due to an increased risk of side effects, especially angioedema. A washout period of at least 36 hours before or after taking an ACE inhibitor is required.
  • Avoid combining with aliskiren if you have diabetes or impaired kidney function, as it can increase the risk of kidney problems and high potassium levels.
  • Caution with potassium-sparing diuretics or potassium supplements as this can increase potassium levels.
  • NSAIDs may reduce the effectiveness and worsen kidney function.
  • May increase lithium levels in the blood.
• Medical Conditions: Inform your doctor if you have kidney or liver problems, low blood pressure, or dehydration. Dose adjustments may be necessary.
• Driving and Machinery: May cause dizziness; exercise caution when driving or operating machinery.

Storage

• Store at room temperature, ideally between 20°C to 25°C, or below 30°C.
• Keep the medicine in its original packaging to protect it from moisture and light.
• Always keep it out of the sight and reach of children.
• Ensure to use the medicine before its expiry date.

Here are some frequently asked questions about Sacurise 50 MG Tablet:

What is Sacurise 50 MG Tablet used for?

Sacurise 50 MG Tablet is primarily used to treat chronic heart failure with reduced ejection fraction in adults. It helps to improve heart function and reduce the risk of cardiovascular death and hospitalization in patients with this condition. It may also be used for children aged 1 to 18 years with heart failure.

How does Sacurise 50 MG Tablet work?

Sacurise 50 MG Tablet is a combination of two active ingredients: sacubitril and valsartan. Sacubitril is a neprilysin inhibitor that works by increasing the levels of beneficial natriuretic peptides in the body, which help to relax and widen blood vessels and promote fluid excretion. Valsartan is an angiotensin II receptor blocker (ARB) that works by blocking the action of angiotensin II, a hormone that causes blood vessels to narrow. Together, these actions help to relax blood vessels, reduce fluid retention, and decrease the heart's workload, thereby improving heart function.

What is the usual dosage for Sacurise 50 MG Tablet?

The dosage of Sacurise 50 MG Tablet is determined by your doctor based on your medical condition and response to the medicine. It is typically taken twice daily, swallowed whole with a glass of water, and can be taken with or without food. It is crucial to follow your doctor's instructions precisely and not to crush, chew, or split the tablets.

What are the possible side effects of Sacurise 50 MG Tablet?

Common side effects of Sacurise 50 MG Tablet may include low blood pressure (hypotension), high potassium levels in the blood (hyperkalemia), cough, dizziness, and kidney problems. Other possible side effects include headache, tiredness, nausea, and diarrhea. A serious but less common side effect is angioedema (swelling of the face, lips, tongue, or throat), which requires immediate medical attention.

Is Sacurise 50 MG Tablet safe during pregnancy or breastfeeding?

No, Sacurise 50 MG Tablet is not recommended for use during pregnancy, especially after the first three months, as it can cause serious harm to the unborn baby. It is also not recommended for breastfeeding women, as the drug may pass into breast milk and potentially harm the baby. Consult your doctor immediately if you become pregnant while taking this medicine.

Can Sacurise 50 MG Tablet be taken with other medications?

Sacurise 50 MG Tablet can interact with certain medications. It should not be taken with ACE inhibitors (e.g., enalapril, lisinopril) and a washout period of at least 36 hours is required when switching between these medications. Concomitant use with aliskiren (a blood pressure-lowering medicine) is contraindicated, especially in patients with diabetes or impaired kidney function. Taking it with potassium-sparing diuretics (e.g., spironolactone), potassium supplements, or certain NSAIDs (non-steroidal anti-inflammatory drugs) can increase the risk of high potassium levels or kidney problems. Always inform your doctor about all other medications, supplements, or herbal products you are taking to avoid potential drug interactions.

What precautions should be taken while taking Sacurise 50 MG Tablet?

Before taking Sacurise 50 MG Tablet, inform your doctor if you have kidney or liver problems, low blood pressure, or a history of angioedema. Regular monitoring of blood pressure, kidney function, and potassium levels is advised during treatment. Avoid consuming foods rich in potassium (like bananas or spinach) or potassium-containing salt substitutes without consulting your doctor, as this can increase potassium levels in your blood. This medication can cause dizziness or tiredness, so exercise caution when driving or operating machinery.

What happens if a dose of Sacurise 50 MG Tablet is missed?

If you miss a dose of Sacurise 50 MG Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should Sacurise 50 MG Tablet be stored?

Sacurise 50 MG Tablet should be stored at room temperature, ideally between 20°C to 25°C, and kept in its original packaging to protect it from moisture. Do not expose it to direct sunlight or heat, and always keep it out of the sight and reach of children.