Teneliglip M 1000

TENELIGLIP M 1000 is a combination oral anti-diabetic medication manufactured by AKUMENTIS HEALTHCARE LTD, prescribed for the management of Type 2 Diabetes Mellitus. It helps improve blood sugar control by targeting multiple pathways involved in glucose regulation.

Composition

TENELIGLIP M 1000 contains two active ingredients:

• Teneligliptin (20 mg)
• Metformin Hydrochloride (1000 mg)

Uses

TENELIGLIP M 1000 is used to treat Type 2 Diabetes Mellitus (also known as non-insulin-dependent diabetes or adult-onset diabetes) in adults. It works to control blood sugar levels by:

• Increasing insulin levels in the body and reducing glucagon levels (Teneligliptin).
• Decreasing liver glucose production and intestinal glucose uptake (Metformin).
• Improving the body's sensitivity to insulin. This action helps to lower both fasting and post-meal glucose levels, preventing serious complications of diabetes such as kidney damage, eye damage, nerve problems, heart disease, and stroke.

Dosage and Administration

This medicine should be taken orally as prescribed by a physician. It is typically recommended to take TENELIGLIP M 1000 once daily with food, preferably with the evening meal, to minimize stomach upset. The tablet should be swallowed whole with a glass of water and not be broken, chewed, or crushed. The duration of treatment depends on the medical condition and response to treatment, as advised by the doctor. Do not exceed the recommended dose to avoid potential overdose and the risk of lactic acidosis.

Side Effects

Common side effects may include:

• Nausea, vomiting, abdominal pain, bloating, constipation, diarrhea.
• Loss of appetite.
• Headache, sore throat, stuffy nose, joint pain.
• Low blood sugar (hypoglycemia), which can cause dizziness, sweating, shakiness, or weakness.
• Allergy/skin reactions or metallic taste in the mouth.

Serious side effects, though rare, can occur and require immediate medical attention:

• Lactic Acidosis: Symptoms include abdominal pain, muscle cramps, severe fatigue, difficulty breathing, dizziness, light-headedness, slow or irregular heartbeat, unusual muscle pain, sleepiness, and drowsiness.
• Serious allergic reaction: Manifests as hives, swelling of the face, lips, tongue or throat, causing difficulty in breathing or swallowing.
• Severe skin rashes with redness and blistering.

Precautions

• Allergies: Do not take if allergic to Teneligliptin, Metformin, or any other ingredients.
• Medical Conditions: Use with caution in patients with heart, liver, or kidney diseases. It is generally not recommended for individuals with severe kidney impairment, liver impairment, congestive heart failure, lactic acidosis, diabetic ketoacidosis, Type 1 diabetes, severe uncontrollable diabetes, or severe systemic infections.
• Alcohol Consumption: Avoid alcohol as it can increase the risk of hypoglycemia and lactic acidosis.
• Pregnancy and Breastfeeding: Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as the medicine is not recommended during these periods.
• Drug Interactions: Inform your doctor about all other medicines, supplements, or herbal products you are taking. Interactions can occur with other anti-diabetic medications, iodine contrast media, bronchodilators, corticosteroids, diuretics, cimetidine, dolutegravir, ranolazine, enalapril, captopril, candesartan, losartan, and Gatifloxacin.
• Vitamin B12 Deficiency: Long-term use may lead to Vitamin B12 deficiency; periodic monitoring is advised.

Storage

Store TENELIGLIP M 1000 in a cool and dry place, protected from direct sunlight, moisture, and heat. Keep it out of the sight and reach of children. The medicine should be stored below 30°C or between 10°C to 25°C.

TENELIGLIP M 1000 is a medication manufactured by Akumentis Healthcare Ltd, primarily used for managing Type 2 Diabetes Mellitus. It combines two active ingredients: Teneligliptin and Metformin hydrochloride.

1. What is TENELIGLIP M 1000 used for?

TENELIGLIP M 1000 is an anti-diabetic medicine prescribed to adults with Type 2 Diabetes Mellitus to help control high blood sugar levels. It is often used when diet and exercise alone, or metformin alone, are not sufficient to manage blood glucose. This helps prevent serious complications of diabetes such as kidney damage, eye damage, nerve problems, and may reduce the risk of heart attack or stroke.

2. How does TENELIGLIP M 1000 work?

This medicine works through a dual mechanism due to its two active ingredients:

• Teneligliptin (20 mg): This is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It increases the levels of incretin hormones (like GLP-1 and GIP), which in turn stimulate the pancreas to release more insulin when blood glucose levels are high and reduce glucagon secretion, thereby lowering blood sugar.
• Metformin hydrochloride (1000 mg): This belongs to the biguanide class. It primarily works by decreasing glucose production in the liver, reducing glucose absorption from the intestines, and enhancing the body's sensitivity to insulin, which increases glucose uptake and utilization by cells.

3. What is the usual dosage for TENELIGLIP M 1000?

TENELIGLIP M 1000 should be taken as prescribed by your doctor. It is typically recommended to take it once daily at the same time each day, preferably with food to reduce stomach upset. It should be swallowed whole without crushing, chewing, or breaking. Your doctor may adjust the dose based on your medical condition and response to treatment.

4. What are the possible side effects of TENELIGLIP M 1000?

Common side effects may include nausea, constipation, abdominal pain, bloating, loss of appetite, diarrhea, headache, stomach upset, and low blood sugar (hypoglycemia). Most of these side effects are temporary and usually resolve over time. However, serious side effects like lactic acidosis can occur, characterized by symptoms such as abdominal pain, muscle cramps, vomiting, severe fatigue, and difficulty breathing. Consult your doctor if side effects persist or worsen, or if you experience symptoms of lactic acidosis.

5. Is TENELIGLIP M 1000 safe during pregnancy or breastfeeding?

TENELIGLIP M 1000 is generally not recommended during pregnancy or breastfeeding. Limited human data suggests the drug may pass into breast milk and potentially harm the baby. If you are pregnant, planning to conceive, or breastfeeding, consult your doctor, who will weigh the benefits against potential risks and may suggest alternative treatments like insulin therapy.

6. Can TENELIGLIP M 1000 be taken with other medications?

TENELIGLIP M 1000 can interact with certain medications. Inform your doctor about all medicines, herbal preparations, and supplements you are taking. Some medicines that may interact include:

• Other anti-diabetic medications (e.g., sulfonylureas, insulin), which can increase the risk of hypoglycemia.
• Cationic medicines like amiloride, cimetidine, and ranitidine, which can increase metformin levels and the risk of lactic acidosis.
• Corticosteroids, bronchodilators, diuretics, and certain antibiotics (e.g., rifampicin) or antifungals (e.g., fluconazole) may also affect its efficacy or increase side effects.
• Iodine contrast media (used for X-rays) require temporary discontinuation of TENELIGLIP M 1000.

7. What precautions should be taken with TENELIGLIP M 1000?

• Lactic Acidosis: Be aware of the risk of lactic acidosis, especially if you have kidney, liver, or heart disease, or consume excessive alcohol. Symptoms include unusual muscle pain, difficulty breathing, stomach pain, and fatigue.
• Alcohol Consumption: Avoid consuming alcohol, as it can increase the risk of hypoglycemia and lactic acidosis.
• Kidney and Liver Disease: Use with caution if you have kidney or liver problems, as dose adjustments may be necessary, and the medicine is contraindicated in severe cases.
• Heart Conditions: Use with caution in patients with heart diseases, including congestive heart failure.
• Vitamin B12 Deficiency: Long-term use may lead to Vitamin B12 deficiency. Your doctor may monitor B12 levels.
• Surgery: Inform your doctor about your diabetes treatment if you are scheduled for surgery under general anesthetic.

8. What happens if a dose of TENELIGLIP M 1000 is missed?

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

9. How should TENELIGLIP M 1000 be stored?

Store TENELIGLIP M 1000 in a cool and dry place, protected from direct sunlight, moisture, and heat. Keep it out of the sight and reach of children. The storage temperature is typically below 30°C.