Zoryl Mv 1/0.3 Tablet

ZORYL MV 1/0.3 TABLET

Name:

• Common Name: Zoryl MV 1/0.3 Tablet, Zoryl MV 1/0.3 Tablet SR
• Brand Name: ZORYL MV 1/0.3 TABLET (by INTAS PHARMACEUTICALS LTD)

Composition: ZORYL MV 1/0.3 TABLET contains a combination of three active ingredients:

• Glimepiride (1 mg)
• Metformin (500 mg, often sustained-release - SR)
• Voglibose (0.3 mg)

Uses: This medicine is prescribed for the management of type 2 diabetes mellitus in adults. It is typically used when diet, exercise, and single-agent or dual therapy are insufficient to achieve adequate blood sugar control. Zoryl MV 1/0.3 Tablet helps in controlling blood sugar levels, regulating glucose metabolism, improving insulin sensitivity, and reducing the risk of diabetes-related complications such as kidney damage, blindness, nerve problems, heart attack, and stroke.

Dosage and Administration: ZORYL MV 1/0.3 TABLET should be taken exactly as prescribed by your doctor. It is generally recommended to take the tablet with or immediately before meals, preferably breakfast. The tablet should be swallowed whole with water and not crushed or chewed. For optimal results, it is advised to take it regularly at the same time each day. Do not stop taking this medicine without consulting your doctor.

Side Effects: Common side effects may include hypoglycemia (low blood sugar levels), taste changes, nausea, diarrhea, abdominal pain, headache, flatulence, loss of appetite, metallic taste, and upper respiratory symptoms. Serious but rare side effects like lactic acidosis can occur, characterized by symptoms such as extreme fatigue, body weakness, and persistent diarrhea.

Precautions:

• Contraindications: Avoid use in patients with type 1 diabetes mellitus, diabetic ketoacidosis, severe kidney or liver disease, acute conditions (e.g., dehydration, severe infection), and known allergy to any of its components or related drugs (sulfonylureas, sulphonamides). It is also contraindicated in pregnancy and breastfeeding.
• Warnings: Inform your doctor about any pre-existing heart disease. Do not skip meals and carry a source of sugar to manage potential low blood sugar. Regular monitoring of blood sugar levels, blood cell counts, and liver function may be advised. Avoid alcohol consumption as it increases the risk of hypoglycemia and lactic acidosis.
• Drug Interactions: Inform your doctor about all other medications you are taking, especially antibacterials, antifungals, other antidiabetic medicines, certain anticancer drugs, disopyramide, and fenyramidol.

Storage: Store ZORYL MV 1/0.3 TABLET in a cool, dry place below 25°C or 30°C. Keep it protected from light and moisture, and out of the sight and reach of children.

What is ZORYL MV 1/0.3 Tablet used for?

ZORYL MV 1/0.3 Tablet is primarily used for managing type 2 diabetes mellitus in adults. It is prescribed when diet, exercise, and single or dual anti-diabetic medications alone are not sufficient to adequately control blood sugar levels. This medicine helps to control high blood glucose levels, reducing the risk of serious complications associated with diabetes such as kidney damage, eye damage, nerve problems, and loss of limbs, as well as reducing the chance of a heart attack or stroke.

How does ZORYL MV 1/0.3 Tablet work?

ZORYL MV 1/0.3 Tablet is a combination of three active ingredients: Glimepiride, Metformin, and Voglibose, each working through different mechanisms to control blood sugar.

• Glimepiride (1 mg): A sulfonylurea that stimulates the pancreatic beta cells to produce and release more insulin, which helps lower blood sugar by allowing cells to take in glucose and increasing the sensitivity of peripheral tissues to insulin.
• Metformin (500 mg): A biguanide that reduces the amount of glucose produced by the liver, slows down the intestinal absorption of glucose, and makes body tissues more sensitive to insulin, thereby enhancing glucose uptake and utilization.
• Voglibose (0.3 mg): An alpha-glucosidase inhibitor that slows down the breakdown of complex carbohydrates into simple sugars in the intestine, which in turn reduces post-meal spikes in blood sugar levels.

What is the usual dosage of ZORYL MV 1/0.3 Tablet?

ZORYL MV 1/0.3 Tablet should be taken as prescribed by your doctor. The dosage can vary based on your health condition and how your body responds to the medicine. It is generally recommended to take this medication with or immediately before meals, preferably breakfast, to help reduce stomach upset and ensure proper absorption. It is crucial to swallow the tablet whole with a glass of water and avoid breaking, crushing, or chewing it. Do not exceed or alter the dose without consulting your doctor.

What are the possible side effects of ZORYL MV 1/0.3 Tablet?

Common side effects of ZORYL MV 1/0.3 Tablet include hypoglycemia (low blood sugar levels), nausea, vomiting, diarrhea, abdominal discomfort/pain, flatulence, altered/metallic taste, headache, and skin reactions. Hypoglycemia can manifest as shakiness, dizziness, or faintness. It is important to recognize the signs of low blood glucose, such as sweating, dizziness, headache, and shaking, and to carry a fast-acting source of glucose (like sugary food or fruit juice) for immediate relief. Serious side effects like lactic acidosis (a rare but life-threatening condition) can occur, with symptoms including extreme fatigue, body weakness, diarrhea, and headache. If you experience any serious or worsening side effects, consult your doctor immediately.

Is ZORYL MV 1/0.3 Tablet safe during pregnancy or breastfeeding?

ZORYL MV 1/0.3 Tablet is generally not recommended for use during pregnancy as it may cause harm to the developing fetus. It is also not recommended for use in breastfeeding women because the medicine may pass into breast milk and potentially harm the nursing child. If you are pregnant, planning to conceive, or breastfeeding, it is essential to consult your doctor for alternative treatment options.

Can ZORYL MV 1/0.3 Tablet be taken with other medications?

ZORYL MV 1/0.3 Tablet can interact with several other medicines. Inform your doctor about all medications, supplements, or herbal products you are currently taking to prevent potential interactions.

• Corticosteroids (e.g., prednisolone, betamethasone): May increase blood glucose levels, reducing the effectiveness of ZORYL MV 1/0.3 Tablet.
• Diuretics (water pills): Can potentially increase blood sugar levels.
• Antibacterials (e.g., rifampicin, ciprofloxacin, clarithromycin, sulfacetamide, minocycline, chloramphenicol) and Antifungals (e.g., fluconazole, isavuconazole, miconazole): May interact with this medicine.
• Other antidiabetics and insulin: Taking ZORYL MV 1/0.3 Tablet with other diabetes medications can increase the risk of low blood sugar (hypoglycemia).
• Alcohol: Should be avoided as it can increase the risk of low blood sugar and potentially lead to lactic acidosis.
• Anti-clot medicines (e.g., phenprocoumon): ZORYL MV 1/0.3 Tablet may alter how these blood thinners work.
• Iodinated contrast media (used in CT scans or MRI): Can increase the risk of lactic acidosis; your doctor may advise stopping the medicine a few days before such procedures.

What precautions should be taken?

Several precautions should be taken while using ZORYL MV 1/0.3 Tablet:

• Kidney and Liver Disease: The medicine is not recommended for patients with severe kidney or liver problems and should be used with caution in mild to moderate liver disease. Regular monitoring of kidney function is advised.
• Heart Disease: Inform your doctor if you have a history of heart disease, including congestive heart failure, as the medicine may not be suitable.
• Alcohol Consumption: Avoid alcohol to prevent imbalances in blood sugar levels and an increased risk of lactic acidosis.
• Type 1 Diabetes and Diabetic Ketoacidosis: ZORYL MV 1/0.3 Tablet is not for use in type 1 diabetes mellitus or in cases of diabetic ketoacidosis.
• Acute Conditions: Not recommended for use in acute conditions such as dehydration, severe infection, shock, severe trauma, or lung problems.
• Allergies: Do not take if you are allergic to glimepiride, metformin, voglibose, or other sulfonylureas or sulfonamides.
• Diet and Exercise: This medication works best when used along with a proper diet and regular exercise.
• Driving and Using Machines: Your ability to drive may be affected if your blood sugar is too low or too high, so exercise caution.
• Do not stop abruptly: Do not stop taking ZORYL MV 1/0.3 Tablet without consulting your doctor, as this could lead to increased blood sugar levels and a higher risk of complications.

What happens if a dose is missed?

If you miss a dose of ZORYL MV 1/0.3 Tablet, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to compensate for a missed one. It's important not to alter your dosage without consulting your doctor.

How should it be stored?

Store ZORYL MV 1/0.3 Tablet in a cool, dry place below 25°C. Keep the medicine protected from light and moisture, and always out of the reach of children. Ensure to use the medicine before the expiry date mentioned on the product packaging.