Lulibrut 1% Cream 30 G

LULIBRUT 1% CREAM 30 G by MANKIND PHARMA LTD.

Name

• Brand Name: LULIBRUT Cream
• Common Name: Luliconazole Cream

Composition LULIBRUT Cream contains Luliconazole 1% w/w as its active ingredient. Luliconazole is a topical antifungal agent belonging to the azole group. It works by inhibiting the enzyme lanosterol demethylase, thereby disrupting the production of ergosterol, a critical component of fungal cell membranes. This action effectively stops fungal growth and kills the fungi.

Uses LULIBRUT Cream is primarily used for the topical treatment of various fungal skin infections. These include:

• Tinea pedis (athlete's foot), a fungal infection between the toes.
• Tinea cruris (jock itch), a red and itchy rash in warm and moist areas of the body.
• Tinea corporis (ringworm), characterized by red, itchy, circular-shaped rashes. It helps to relieve symptoms such as itching, redness, irritation, and scaling, while also preventing the spread of the infection.

Dosage and Administration LULIBRUT Cream is for external application only.

• General Application: Clean and dry the affected area before applying a thin layer of the cream. Extend the application to about 1 inch (2.5 cm) of the surrounding healthy skin. Wash hands thoroughly after application, unless the hands are the area being treated.
• Tinea Pedis (Athlete's Foot): Typically applied once daily for two weeks.
• Tinea Cruris (Jock Itch) and Tinea Corporis (Ringworm): Usually applied once daily for one week. Complete the full course of treatment as prescribed by a doctor, even if symptoms improve, to prevent recurrence.

Side Effects Common side effects are generally mild and may include application site reactions such as:

• Irritation or burning sensation.
• Itching.
• Redness or skin dryness.
• Skin exfoliation. In rare cases, severe allergic reactions (e.g., skin rash, hives, swelling of face/lips/tongue, difficulty breathing) may occur, requiring immediate medical attention.

Precautions

• Hypersensitivity: Do not use LULIBRUT Cream if allergic to Luliconazole or any of its ingredients.
• External Use Only: Avoid contact with eyes, mouth, nose, or vaginal region. If accidental contact occurs, rinse thoroughly with water.
• Pregnancy and Breastfeeding: Not generally recommended for use in pregnant or breastfeeding women unless considered clearly necessary by a doctor.
• Pediatric Use: Not recommended for children 12 years of age and below unless clearly necessary and advised by a doctor.
• Elderly Patients: Use with caution in elderly patients (aged 65 years or older).
• Broken Skin/Open Wounds: Use with caution on broken skin or open wounds as it may lead to increased systemic absorption.
• Monitoring: If the condition does not improve after two weeks (for athlete's foot) or one week (for jock itch/ringworm), consult a doctor.

Storage Store LULIBRUT Cream in its original packaging in a cool, dry place. Do not freeze. Keep the medicine away from light, excess heat, moisture, and out of the reach of children and pets. Ensure the cap is tightly replaced after use. Store at a temperature not exceeding 30°C or 25°C, depending on specific product guidelines.

LULIBRUT 1% CREAM 30 G by MANKIND PHARMA LTD. (containing Luliconazole) is an antifungal medication used for topical treatment of various fungal skin infections.

What is LULIBRUT 1% CREAM used for?

LULIBRUT 1% CREAM is primarily used to treat fungal skin infections such as athlete's foot (tinea pedis), jock itch (tinea cruris), and ringworm (tinea corporis). It helps relieve symptoms like itching, redness, irritation, and scaling associated with these infections.

How does LULIBRUT 1% CREAM work?

This cream contains Luliconazole, which is an antifungal agent belonging to the azole group. It works by inhibiting an enzyme called lanosterol demethylase, which is vital for the production of ergosterol. Ergosterol is a crucial component of the fungal cell membrane. By disrupting ergosterol synthesis, Lulibrut damages the fungal cell membrane, leading to the death of the fungi and clearing the infection.

What is the usual dosage for LULIBRUT 1% CREAM?

LULIBRUT 1% CREAM is for external use only. Typically, a thin layer of the cream should be applied to the affected skin area and approximately one inch of the surrounding healthy skin once daily. The duration of treatment varies: for athlete's foot (interdigital tinea pedis), it's usually applied for two weeks, while for jock itch (tinea cruris) and ringworm (tinea corporis), it's generally applied for one week. Always follow your doctor's specific instructions.

What are the possible side effects of LULIBRUT 1% CREAM?

Common side effects at the application site may include a burning or stinging sensation, itching, redness, irritation, and skin dryness or peeling. These reactions are usually mild and tend to resolve on their own over time. If these side effects persist or worsen, or if you experience signs of a severe allergic reaction (like rash, swelling of the face/lips/tongue/throat, or difficulty breathing), seek immediate medical attention.

Is LULIBRUT 1% CREAM safe during pregnancy or breastfeeding?

Pregnancy: LULIBRUT 1% CREAM is generally not recommended during pregnancy unless clearly necessary, as there is limited human data on its safety, and animal studies have shown harmful effects at higher doses. Always consult your doctor to discuss the potential benefits versus risks to your unborn baby. Breastfeeding: Use with caution during breastfeeding. While systemic absorption through the skin is low, it is not known if Luliconazole passes into human milk. Avoid applying the cream to the breast or nipple area, and ensure that the infant's skin does not come into direct contact with treated areas.

Can LULIBRUT 1% CREAM be taken with other medications?

Since LULIBRUT 1% CREAM is applied topically, it is less likely to interact with medications taken orally or by injection. However, prolonged use of large amounts might potentially interact with certain medicines like omeprazole. It is important to inform your doctor about all other medications you are currently taking, including herbal supplements, especially if you are using other steroid-containing creams or antifungal medicines.

What precautions should be taken while using LULIBRUT 1% CREAM?

LULIBRUT 1% CREAM is for external use only. Avoid contact with your eyes, mouth, nose, or vagina. If accidental contact occurs, rinse the area thoroughly with plenty of water. Do not cover the treated area with bandages or dressings unless specifically instructed by your doctor. Complete the full course of treatment as prescribed, even if your symptoms improve, to prevent the infection from returning. This cream is generally not recommended for children under 12 years for athlete's foot or jock itch, or under 2 years for ringworm, due to insufficient safety and efficacy data.

What happens if a dose of LULIBRUT 1% CREAM is missed?

If you miss a dose of LULIBRUT 1% CREAM, apply it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular application schedule. Do not apply a double dose to make up for the missed one.

How should LULIBRUT 1% CREAM be stored?

Store LULIBRUT 1% CREAM in its original container, tightly closed, at room temperature, typically between 20°C to 25°C (68°F to 77°F). Keep it away from light, excess heat, and moisture, and do not store it in the bathroom. Ensure it is kept out of the reach of children and pets.