Sitacip Dm 100/10/500 Tablet (10tab)

SITACIP DM 100/10/500 TABLET

Name: SITACIP DM 100/10/500 TABLET (Brand name) by Cipla Ltd.

Composition: Each tablet contains:

• Sitagliptin: 100 mg
• Dapagliflozin: 10 mg
• Metformin: 500 mg

Uses: SITACIP DM 100/10/500 TABLET is prescribed for adults with type 2 diabetes mellitus. It is used to manage blood sugar levels when diet, exercise, and other conventional therapies (like metformin alone or dual therapy with metformin and either dapagliflozin or sitagliptin) do not provide adequate glycemic control. This medication also aids in weight management and helps reduce cardiovascular risk, working to prevent diabetes-related complications such as kidney damage and blindness.

Dosage and Administration: This medicine should be taken orally, typically once or twice daily, as advised by a physician. It can be taken with or without meals, though taking it with meals may help minimize gastrointestinal side effects. The tablet should be swallowed whole and not crushed or chewed. It is crucial to adhere strictly to the prescribed dosage and to take the medicine at the same time each day for optimal benefits.

Side Effects:

• Common: Genital infections, common cold, diarrhea, headache, nausea, influenza, back pain, cough, urinary tract infection, nasopharyngitis, hypoglycemia (low blood glucose), vomiting, flatulence, increased urination, drowsiness, dizziness, stomach pain, itching, dry mouth, decreased weight, and thirst.
• Serious: Seek immediate medical attention for symptoms of acute pancreatitis (severe, persistent abdominal pain), severe allergic reactions (rash, swelling of face/lips/tongue, difficulty breathing), bullous pemphigoid (blistering skin), lactic acidosis (weakness, breathing difficulty, stomach pain, unexplained weight loss), or ketoacidosis (nausea, vomiting, confusion, fruity breath).

Precautions: SITACIP DM 100/10/500 TABLET is not recommended for individuals with severe kidney impairment, end-stage renal disease, type 1 diabetes, metabolic acidosis, severe liver disease, respiratory failure, or heart failure. Patients who are pregnant or breastfeeding should consult their doctor before use. Alcohol consumption should be avoided due to an increased risk of lactic acidosis. Regular monitoring of blood sugar and kidney function is essential. Inform your doctor about any pre-existing conditions or other medications, including diuretics, insulin, or sulphonylureas, as interactions may occur.

Storage: Store the medicine below 30°C in a cool and dry place, away from direct sunlight. Keep it out of the sight and reach of children.

SITACIP DM 100/10/500 Tablet by Cipla Ltd. is a combination medication used for the management of type 2 diabetes mellitus in adults. This medicine contains three active ingredients: Dapagliflozin (10mg), Sitagliptin (100mg), and Metformin (500mg). It is prescribed as an adjunct to diet and exercise to help improve blood sugar control.

What is SITACIP DM 100/10/500 Tablet used for?

SITACIP DM 100/10/500 Tablet is primarily used to manage type 2 diabetes mellitus in adults. It is prescribed when blood sugar levels are not adequately controlled by metformin alone, or by dual therapy with metformin and either dapagliflozin or sitagliptin. This medication also aids in weight management and helps reduce cardiovascular risk in individuals with type 2 diabetes.

How does SITACIP DM 100/10/500 Tablet work?

This tablet combines three active ingredients that work through different mechanisms to lower blood sugar levels:

• Dapagliflozin (10mg): This is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that reduces the reabsorption of glucose in the kidneys, leading to increased glucose excretion through urine and thus lowering blood glucose levels.
• Sitagliptin (100mg): A dipeptidyl peptidase-4 (DPP-4) inhibitor, sitagliptin enhances the body's incretin system. It increases the release of insulin from the pancreas and decreases glucagon secretion from the liver when blood sugar levels are high.
• Metformin (500mg): A biguanide, metformin works by decreasing glucose production in the liver and reducing glucose absorption from the intestines. It also improves the body's sensitivity to insulin, allowing for better glucose uptake by muscles and tissues.

What is the usual dosage of SITACIP DM 100/10/500 Tablet?

The dosage of SITACIP DM 100/10/500 Tablet is individualized by your doctor based on your blood glucose levels, kidney function, and other medications you may be taking. It is typically taken orally, once or twice daily, with meals to minimize potential gastrointestinal side effects. The tablet should be swallowed whole with a glass of water and not crushed, split, or chewed. It's important to take this medicine consistently at the same time each day for optimal benefits.

What are the possible side effects of SITACIP DM 100/10/500 Tablet?

Common side effects may include genital infections, common cold, diarrhea, headache, nausea, influenza, back pain, and cough. Other reported side effects include urinary tract infections, nasal congestion, sore throat, upper respiratory tract infections, flatulence, drowsiness, dizziness, constipation, stomach pain, itching, dry mouth, decreased weight, and thirst. Serious but rare side effects like lactic acidosis (due to metformin accumulation), ketoacidosis, and acute pancreatitis symptoms (severe abdominal pain with or without nausea and vomiting) require immediate medical attention.

Is SITACIP DM 100/10/500 Tablet safe during pregnancy or breastfeeding?

SITACIP DM 100/10/500 Tablet is generally not recommended during pregnancy or breastfeeding. Limited information is available regarding its effects in pregnant women, and metformin, one of its components, is known to pass into human breast milk. It is crucial to consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding before taking this medication.

Can SITACIP DM 100/10/500 Tablet be taken with other medications?

SITACIP DM 100/10/500 Tablet can interact with other medicines. Inform your doctor about all prescription, non-prescription, herbal supplements, and vitamins you are currently taking. Particular care should be taken if you are using diuretics (water pills), insulin, insulin secretagogues (like sulfonylureas, e.g., glimepiride), or medicines for fungal infections (e.g., ketoconazole), bacterial infections (e.g., clarithromycin), or HIV/AIDS (e.g., ritonavir). Co-administration with certain iodine-containing contrast agents can increase the risk of lactic acidosis.

What precautions should be taken with SITACIP DM 100/10/500 Tablet?

Before taking this medicine, inform your doctor if you have any kidney or liver issues, a urinary tract infection, or heart failure. Patients with hepatic impairment should avoid this medication due to an increased risk of lactic acidosis from metformin. Avoid excessive alcohol consumption as it can increase the risk of side effects, including lactic acidosis and hypoglycemia. Regular monitoring of blood sugar levels is crucial while taking this medication. This medicine is not recommended for individuals with type 1 diabetes, diabetic ketoacidosis, acute metabolic acidosis, or severe respiratory failure.

What happens if a dose of SITACIP DM 100/10/500 Tablet is missed?

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should SITACIP DM 100/10/500 Tablet be stored?

SITACIP DM 100/10/500 Tablet should be stored in a cool and dry place, below 30°C, away from direct sunlight. Keep it out of the sight and reach of children.