Uniaz T 40

UNIAZ T 40 by TORRENT PHARMACEUTICALS LTD

UNIAZ T 40 is a combination medication manufactured by Torrent Pharmaceuticals Ltd. used primarily for the treatment of hypertension.

Composition

UNIAZ T 40 contains two active ingredients:

• Azelnidipine (8 mg): A dihydropyridine calcium channel blocker that works by relaxing blood vessels, which leads to their widening and increased blood supply to the heart.
• Telmisartan (40 mg): An angiotensin II receptor blocker (ARB) that blocks substances responsible for constricting blood vessels, thereby allowing blood to flow more smoothly and reducing the heart's workload.

Uses

UNIAZ T 40 is prescribed for the following medical conditions:

• Hypertension (High Blood Pressure): It is commonly used for managing high blood pressure, particularly in Stage II Hypertension or when single-medicine therapies are insufficient.
• Cardiovascular Risk Reduction: By effectively controlling blood pressure, it helps to reduce the risk of serious cardiovascular events such as heart attacks and strokes.
• Other Benefits: It may also be beneficial in the treatment of heart failure, stroke prevention, prevention of heart attack, diabetic nephropathy, and kidney disease by improving blood flow and lowering the heart's workload.

Dosage and Administration

• UNIAZ T 40 is taken orally as prescribed by a healthcare professional.
• Typically, it is taken once daily, preferably at the same time each day to maintain consistent medication levels in the body.
• It can be taken with or without food.
• Tablets should be swallowed whole with a glass of water; they should not be crushed, chewed, or broken.
• Do not discontinue the medication abruptly without consulting your doctor, as this can lead to fluctuations in blood pressure. Your doctor will advise on gradual tapering if necessary.

Side Effects

Common side effects may include:

• Dizziness, headache
• Nausea, diarrhea, stomach ache
• Numbness, flu-like symptoms, back pain
• Sinus infection, lung and airway infection
• Facial flush, palpitations
• Fatigue, weakness

Most of these side effects are usually mild and temporary. If they persist or worsen, it is advisable to consult a doctor. UNIAZ T 40 may cause dizziness or drowsiness, which can affect the ability to drive or operate machinery. Overdose symptoms can include irregular heartbeat, severe dizziness, low blood pressure, kidney failure, and loss of consciousness.

Precautions

• Pregnancy: UNIAZ T 40 is generally contraindicated during the second and third trimesters of pregnancy and is not recommended if planning to conceive. Consult your doctor for safer alternatives.
• Breastfeeding: The use of UNIAZ T 40 is not advised during breastfeeding due to potential risks to the infant; consult a healthcare provider.
• Alcohol: It is recommended to avoid or limit alcohol consumption while taking this medication as it may increase dizziness, fatigue, and further lower blood pressure.
• Liver Disease: Use with caution in patients with liver impairment, especially severe cases. Doctor consultation is advised.
• Kidney Disease: While generally considered safe for patients with kidney disease, caution is advised for those with a history of kidney problems or narrowing of renal blood vessels. Regular monitoring of kidney function, blood creatinine, and potassium levels may be required.
• Diabetes: Diabetic patients may take UNIAZ T 40 if prescribed by their doctor, but regular monitoring of blood sugar levels is crucial.
• Drug Interactions: Inform your doctor about all other medications, including over-the-counter drugs and herbal supplements, to prevent potential interactions. UNIAZ T 40 can interact with other blood pressure-lowering medicines, certain antifungals, antibiotics, steroids, and muscle relaxants, potentially leading to adverse effects.
• Dehydration: Conditions leading to dehydration, such as severe diarrhea or vomiting, can result in low blood pressure; monitor closely.
• Elderly Patients: Caution is advised when prescribing to elderly patients, and dose adjustments may be necessary.
• Lifestyle: Adopting a low-sodium diet, maintaining a healthy weight, regular exercise, and avoiding smoking can enhance the effectiveness of UNIAZ T 40.

Storage

• Store UNIAZ T 40 in a cool and dry place, protected from light and moisture.
• Keep out of the sight and reach of children and pets.
• Store below 25°C or 30°C.

What is Uniaz T 40 used for?

Uniaz T 40 Tablet is primarily used to treat hypertension, also known as high blood pressure. It is particularly effective for managing Stage II hypertension or when single-medicine therapies are not sufficient. This medication also helps reduce the risk of associated cardiovascular complications like heart attacks and strokes.

How does Uniaz T 40 work?

Uniaz T 40 Tablet is a combination medication containing Azelnidipine (8mg) and Telmisartan (40mg). Azelnidipine is a dihydropyridine calcium channel blocker that works by inhibiting calcium ion inflow into the muscle cells of blood vessels, causing them to widen and thereby lowering blood pressure. Telmisartan is an angiotensin II receptor blocker that selectively blocks angiotensin II from binding to AT1 receptors. Angiotensin II normally constricts blood vessels, so by blocking its action, Telmisartan promotes blood vessel dilation and reduces blood volume, further contributing to lower blood pressure.

What is the usual dosage for Uniaz T 40?

The dosage of Uniaz T 40 is determined by your doctor based on your medical condition and response to treatment. Typically, the starting dose is 40mg taken once daily. It should be swallowed whole with a glass of water, without crushing or chewing. It can be taken with or without food, but it is recommended to take it at the same time each day to maintain a consistent level of medication in your system. Do not stop taking the medicine without your doctor's advice.

What are the possible side effects of Uniaz T 40?

Common side effects of Uniaz T 40 Tablet may include dizziness, headache, nausea, diarrhea, fatigue, weakness, and numbness. These side effects are usually mild and tend to resolve over time. If they persist or worsen, it is important to consult your doctor. In cases of overdose, symptoms like irregular heartbeat, significant low blood pressure, dizziness, and potentially kidney failure or loss of consciousness may occur, requiring immediate medical attention.

Is Uniaz T 40 safe during pregnancy or breastfeeding?

Uniaz T 40 Tablet is contraindicated during the second and third trimesters of pregnancy and should not be taken during pregnancy or if you are planning to conceive, as it may cause severe side effects to the unborn baby. It is also not advised during breastfeeding due to potential risks to the infant. Always consult your doctor if you are pregnant, planning pregnancy, or breastfeeding before taking this medicine.

Can Uniaz T 40 be taken with other medications?

Uniaz T 40 can interact with several medications. Using it with other blood pressure-lowering medications may cause a significant drop in blood pressure. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) like ibuprofen may reduce its blood pressure-lowering effects. Concurrent use with cardiac glycosides like digoxin can increase digoxin levels. Muscle relaxants such as dantrolene, and medicines that modify immune response like cyclosporin and tacrolimus, may also interact. If you have diabetes or severe kidney impairment and are being treated with Aliskiren, Uniaz T 40 should not be taken. Medicines that elevate blood potassium levels should be monitored closely. Always inform your doctor about all other medications, herbal preparations, and supplements you are taking to avoid potential interactions.

What precautions should be taken while on Uniaz T 40?

It is advisable to avoid alcohol consumption while taking Uniaz T 40, as it may increase the risk of dizziness, low blood pressure, and other adverse effects. Grapefruit juice should also be avoided as it may increase the risk of side effects, and high potassium-containing foods should be limited. Exercise caution if you have liver disease, kidney problems, diabetes, congestive heart failure, or conditions leading to dehydration. Uniaz T 40 may cause dizziness or weakness, so it is recommended not to drive or operate machinery until you know how the medicine affects you. Your doctor may recommend regular monitoring of blood pressure, kidney function, and blood glucose levels. Do not stop taking this medication suddenly without consulting your doctor.

What happens if a dose of Uniaz T 40 is missed?

If you miss a dose of Uniaz T 40 Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should Uniaz T 40 be stored?

Uniaz T 40 Tablet should be stored in its original packaging in a cool and dry place, protected from light. Keep it out of the sight and reach of children and pets.