Xet Cr 12.5 Mg Tablet (10 Tab)

XET CR 12.5 MG TABLET

XET CR 12.5 MG TABLET is an antidepressant belonging to the selective serotonin reuptake inhibitor (SSRI) group of medicines, manufactured by ZYDUS HEALTHCARE LIMITED.

• Composition

  • Active Ingredients: Paroxetine (12.5 mg).

• Uses XET CR 12.5 MG TABLET is primarily prescribed to treat various mental health conditions by increasing serotonin levels in the brain, a chemical messenger that helps regulate mood. It is used for:

  • Major depressive disorder
  • Obsessive-compulsive disorder (OCD)
  • Panic disorder
  • Social anxiety disorder
  • Post-traumatic stress disorder (PTSD)
  • Generalized anxiety disorder
  • Premenstrual dysphoric disorder (PMDD)

• Dosage and Administration

  • Take XET CR 12.5 MG TABLET as prescribed by your doctor.
  • It is usually taken once daily, typically in the morning, with or without food. Taking it with food may help reduce stomach upset.
  • Swallow the tablet whole with a glass of water; do not crush, break, or chew it.
  • The dosage may be started at a lower level and gradually increased by your doctor based on your medical condition and response to treatment. Do not discontinue or change the dose without consulting your doctor, as this may worsen your condition or lead to withdrawal symptoms.

• Side Effects

  • Common Side Effects: Nausea, dizziness, headache, insomnia (difficulty sleeping), fatigue, dry mouth, loss of appetite, diarrhea, increased sweating, nervousness, tremors, constipation, and sexual disturbances (decreased sexual desire, delayed ejaculation, erectile dysfunction).
  • Serious Side Effects (Contact your doctor immediately if experienced): Unusual bruising or bleeding, difficult urination, fits (seizures), feelings of restlessness or inability to sit/stand still (akathisia), signs of low sodium (tiredness, weakness, confusion, achy muscles), and suicidal thoughts.

• Precautions

  • Pregnancy: XET CR 12.5 MG TABLET is not recommended during pregnancy as it may harm the fetus.
  • Breastfeeding: Use with caution during breastfeeding as it may pass into breastmilk. Consult your doctor.
  • Alcohol: Avoid alcohol consumption as it may worsen side effects like dizziness and sleepiness.
  • Driving and Operating Machinery: Avoid driving or operating heavy machinery if you experience dizziness, confusion, sleepiness, or blurred vision.
  • Children and Adolescents: Not recommended for individuals under 18 years of age due to potential safety and effectiveness concerns, including an increased risk of suicidal thoughts and aggressive behavior.
  • Elderly Patients: Use with caution in patients above 65 years of age.
  • Medical Conditions: Inform your doctor if you have epilepsy, diabetes (may alter blood sugar levels), liver or kidney disease, heart problems, or glaucoma.
  • Drug Interactions: Do not take with MAOIs (Monoamine Oxidase Inhibitors); a 14-day gap is advised between stopping one medicine and starting the other. Caution is also advised with NSAIDs/painkillers, certain anti-allergics, and antipsychotics due to potential increased risk of side effects or interactions.

• Storage

  • Store in a cool and dry place, away from direct sunlight.
  • Keep out of reach and sight of children.
  • Typically, store below 25°C or 30°C.

What is XET CR 12.5 MG TABLET used for?

XET CR 12.5 MG TABLET, which contains Paroxetine hydrochloride as its active ingredient, is a controlled-release antidepressant used to treat various mental health conditions. It is primarily prescribed for major depressive disorder (MDD), panic disorder (PD), social anxiety disorder (SAD), obsessive-compulsive disorder (OCD), generalized anxiety disorder (GAD), post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD).

How does XET CR 12.5 MG TABLET work?

XET CR 12.5 MG TABLET belongs to a class of medications called Selective Serotonin Reuptake Inhibitors (SSRIs). It works by increasing the levels of serotonin, a natural chemical messenger in the brain. Serotonin plays a crucial role in regulating mood, emotions, sleep, and appetite. By blocking the reuptake of serotonin by nerve cells, XET CR 12.5 MG TABLET enhances its availability in the brain, which helps to improve mood and alleviate symptoms of depression and anxiety disorders.

What is the usual dosage for XET CR 12.5 MG TABLET?

For XET CR 12.5 MG TABLET, the typical starting dose is 12.5 mg once daily, usually taken in the morning, with or without food. Your doctor will determine the appropriate dosage based on your condition and response to treatment. The dose may be gradually increased, but it is important not to change the dose or stop taking it without consulting your doctor. For major depressive disorder or panic disorder, the maximum recommended dosage can go up to 50 mg per day. For social anxiety disorder, the maximum is typically 37.5 mg per day. The tablets should be swallowed whole and not chewed or crushed.

What are the possible side effects of XET CR 12.5 MG TABLET?

Common side effects can include nausea, dry mouth, sweating, drowsiness or somnolence, insomnia (difficulty sleeping), dizziness, headache, decreased appetite, constipation, diarrhea, and sexual problems such as decreased sex drive or delayed ejaculation.

More serious side effects, though less common, can include:

• Suicidal thoughts or actions: Especially in children, teenagers, and young adults, paroxetine may increase the risk of suicidal thoughts or behaviors, particularly during the initial months of treatment or when the dosage is changed.
• Serotonin Syndrome: A potentially life-threatening condition caused by too much serotonin, with symptoms like agitation, hallucinations, confusion, rapid heartbeat, muscle stiffness, twitching, sweating, fever, nausea, vomiting, or diarrhea.
• Abnormal bleeding or bruising: Especially if taken with other medications that increase bleeding risk.
• Mania or hypomania: Particularly in individuals with undiagnosed bipolar disorder.
• Seizures: Some people taking paroxetine have reported seizures.
• Glaucoma: Paroxetine may increase pressure inside the eye, worsening narrow-angle glaucoma.
• Low sodium levels (hyponatremia): Symptoms may include headache, confusion, weakness, or muscle cramps.

If you experience any severe or concerning side effects, contact your healthcare provider immediately.

Is XET CR 12.5 MG TABLET safe during pregnancy or breastfeeding?

• Pregnancy: Paroxetine can be used during pregnancy, but some studies suggest a small, though often not definitive, increased risk of heart defects in the baby if taken during the first trimester. Taking it in the weeks leading up to delivery may also cause temporary withdrawal symptoms or breathing problems in the newborn. It is crucial to discuss the potential risks and benefits with your doctor to determine the best course of action for you and your baby.
• Breastfeeding: Paroxetine passes into breast milk in small amounts and is generally considered one of the preferred antidepressants for breastfeeding mothers. While occasional mild side effects have been reported in breastfed infants, the overall risk is low. It's advisable to monitor your baby for any unusual symptoms like agitation, irritability, poor feeding, or excessive sleepiness, and discuss any concerns with your healthcare provider.

Can XET CR 12.5 MG TABLET be taken with other medications?

XET CR 12.5 MG TABLET can interact with several other medications, which may lead to serious side effects.

• Do not take with: Monoamine Oxidase Inhibitors (MAOIs) (a 14-day washout period is required before starting or after stopping paroxetine), thioridazine, or pimozide.
• Increased risk of Serotonin Syndrome: Combining with other medications that increase serotonin levels can lead to serotonin syndrome. These include other SSRIs, SNRIs (serotonin-norepinephrine reuptake inhibitors), tricyclic antidepressants (TCAs), triptans (for migraines), tramadol, lithium, buspirone, tryptophan, and the herbal supplement St. John's wort.
• Increased bleeding risk: Taking with aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen, or blood thinners such as warfarin, apixaban, or rivaroxaban can increase the risk of bleeding or bruising.
• Other significant interactions: Paroxetine can also interact with tamoxifen (potentially reducing its effectiveness), certain antipsychotics, and medications that affect liver enzymes (especially CYP2D6 inhibitors).

Always inform your doctor and pharmacist about all prescription, over-the-counter, herbal, and vitamin supplements you are currently taking to avoid potential interactions.

What precautions should be taken while taking XET CR 12.5 MG TABLET?

• Do not stop abruptly: Do not stop taking XET CR 12.5 MG TABLET suddenly, as this can lead to withdrawal symptoms such as anxiety, irritability, mood changes, dizziness, headache, nausea, sweating, and electric shock-like sensations. Your doctor will guide you on gradually reducing the dose if needed.
• Monitor for suicidal thoughts: Closely monitor for any new or worsening suicidal thoughts or unusual changes in behavior, especially at the beginning of treatment or when the dose is changed, particularly in young adults.
• Medical history: Inform your doctor if you have a history of bipolar disorder, mania, seizures, glaucoma, low sodium levels, heart, liver, or kidney problems, or bleeding disorders.
• Alcohol: Avoid drinking alcohol while taking this medication.
• Driving and operating machinery: Be cautious when driving or operating machinery until you know how the medication affects you, as it can cause dizziness or drowsiness.

What happens if a dose of XET CR 12.5 MG TABLET is missed?

If you miss a dose of XET CR 12.5 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this could lead to increased side effects.

How should XET CR 12.5 MG TABLET be stored?

Store XET CR 12.5 MG TABLET at room temperature, typically between 20°C to 25°C (68°F to 77°F), away from excessive heat, moisture, and direct light. Keep the bottle tightly closed and ensure it is out of reach of children.