Arney 50 Mg Tablet (14 Tab)

ARNEY 50 MG TABLET is a medication manufactured by Intas Pharmaceuticals Ltd. for the management of chronic heart failure.

Name

• Brand Name: ARNEY 50 MG TABLET
• Common Name: Sacubitril and Valsartan

Composition

Each film-coated tablet contains:

• Sacubitril: 24 mg
• Valsartan: 26 mg

Uses

ARNEY 50 MG TABLET is prescribed for the treatment of chronic heart failure with reduced ejection fraction in adult patients. It helps to improve heart function, alleviate symptoms such as fatigue, swelling, and shortness of breath, and reduce the risk of cardiovascular death and hospitalization. It may also be used in children over one year of age under strict medical supervision.

Dosage and Administration

The dosage is determined by a healthcare professional based on the patient's condition and response to treatment. The recommended starting dose for ARNEY is typically 49 mg sacubitril/51 mg valsartan (often referred to as 100 mg total) orally twice daily, with titration to a target maintenance dose of 97 mg sacubitril/103 mg valsartan (200 mg total) twice daily as tolerated. For patients not currently taking an ACE inhibitor or ARB, or those previously on low doses, starting at half the usually recommended starting dose may be advised. ARNEY 50 MG TABLET should be swallowed whole with a glass of water, and can be taken with or without food. It is important not to discontinue the medicine without consulting a doctor.

Side Effects

Common side effects of ARNEY 50 MG TABLET may include:

• Low blood pressure (hypotension)
• Increased potassium levels in the blood (hyperkalemia)
• Cough
• Dizziness, light-headedness, or fainting
• Headache
• Fatigue/weakness
• Nausea
• Diarrhea
• Decreased renal function

Serious side effects include severe allergic reactions such as angioedema (swelling of the face, lips, tongue, or throat, which may cause difficulties in breathing or swallowing). Immediate medical attention is required if angioedema occurs.

Precautions

• Contraindications: Do not take ARNEY 50 MG TABLET if you are allergic to sacubitril, valsartan, or any other ingredients. It is contraindicated with concomitant use of an Angiotensin-Converting Enzyme (ACE) inhibitor; a washout period of at least 36 hours is required when switching between an ACE inhibitor and ARNEY. Patients with diabetes or impaired kidney function taking a medicine containing aliskiren should not use ARNEY. It is also contraindicated in severe liver disease and during pregnancy.
• Pregnancy and Breastfeeding: ARNEY is not recommended during pregnancy and breastfeeding, as it may cause harm or death to an unborn baby.
• Drug Interactions: Inform your doctor about all medications you are taking. Interactions can occur with ACE inhibitors, potassium-sparing diuretics, potassium supplements, NSAIDs, lithium, and other blood pressure medications.
• Medical Conditions: Use with caution in patients with kidney or liver problems, low blood pressure, or a history of angioedema. Patients with an activated renin-angiotensin system, such as those with volume or salt depletion, are at greater risk of symptomatic hypotension.

Storage

Keep ARNEY 50 MG TABLET in a dry area, protected from moisture and direct sunlight. The ideal storage condition is a temperature below 30°C (or between 20-25°C). Keep it out of reach of children. Always check the expiry date and ensure the medicine is used before it expires.

What is ARNEY 50 MG TABLET used for?

ARNEY 50 MG TABLET is primarily used to treat chronic heart failure in adults, particularly those with reduced ejection fraction. It helps to reduce the risk of cardiovascular death and hospitalization associated with heart failure. In some cases, it may also be prescribed for children over one year of age under strict medical supervision for heart failure.

How does ARNEY 50 MG TABLET work?

ARNEY 50 MG TABLET is a combination medication containing two active ingredients: Sacubitril and Valsartan. Sacubitril is a neprilysin inhibitor, which increases the levels of beneficial natriuretic peptides in the body. These peptides help widen blood vessels, increase urine output, and reduce sodium retention, thereby easing the heart's workload. Valsartan is an angiotensin receptor blocker (ARB) that blocks the effects of a hormone called angiotensin II, which normally constricts blood vessels. Together, these actions relax and widen blood vessels, making it easier for the heart to pump blood throughout the body and reducing fluid accumulation.

What is the usual dosage for ARNEY 50 MG TABLET?

The recommended starting dose for adults is typically 49/51 mg (which corresponds to one ARNEY 50 MG TABLET) taken orally twice daily. Your doctor may double the dose after 2 to 4 weeks to a target maintenance dose of 97/103 mg twice daily, if tolerated. The exact dosage will be determined by your physician based on your specific medical condition and how you respond to the medicine. The tablet should be swallowed whole with water and should not be chewed, crushed, or broken. It can be taken with or without food.

What are the possible side effects of ARNEY 50 MG TABLET?

Common side effects may include low blood pressure (hypotension), increased potassium levels in the blood (hyperkalemia), cough, dizziness, headache, fatigue, weakness, and diarrhea. Some serious side effects, though rare, can include angioedema (swelling of the face, lips, tongue, or throat) and worsening kidney function. If you experience any severe or persistent side effects, you should consult your doctor.

Is ARNEY 50 MG TABLET safe during pregnancy or breastfeeding?

No, ARNEY 50 MG TABLET is not recommended during pregnancy as it can cause serious harm to the unborn baby. Women of childbearing potential should use effective contraception during treatment and for at least one week after their last dose. It is also generally not recommended during breastfeeding because the medication may pass into breast milk and potentially harm the infant.

Can ARNEY 50 MG TABLET be taken with other medications?

ARNEY 50 MG TABLET should not be taken with Angiotensin-Converting Enzyme (ACE) inhibitors (e.g., enalapril, lisinopril, ramipril); a washout period of at least 36 hours is required before or after switching between these medications. It is also contraindicated with aliskiren, especially in patients with diabetes or kidney disease. Concomitant use with other angiotensin receptor blockers (ARBs) should be avoided. Caution is advised when taking it with potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium, and nonsteroidal anti-inflammatory drugs (NSAIDs) as these can increase the risk of side effects like elevated potassium levels or worsening kidney function. Inform your doctor about all medications you are currently taking, including herbal supplements.

What precautions should be taken while taking ARNEY 50 MG TABLET?

Inform your doctor if you have kidney or liver disease, diabetes, or a history of angioedema. You may experience dizziness, especially when standing up, so rise slowly and carefully. Avoid consuming alcohol, as it can intensify dizziness. Do not drive or operate heavy machinery if you feel dizzy or tired. Regular monitoring of your blood pressure, kidney function, and serum potassium levels will be conducted by your doctor. A low-sodium diet and gentle exercise may also be beneficial.

What happens if a dose of ARNEY 50 MG TABLET is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for a missed one.

How should ARNEY 50 MG TABLET be stored?

ARNEY 50 MG TABLET should be stored in a cool and dry place, away from direct sunlight and moisture. The ideal storage temperature is below 30°C (some sources specify 10°C to 25°C). Keep the medication in its original packaging to protect it from light and ensure it is kept out of the sight and reach of children.