Valkem Od 250

VALKEM OD 250

VALKEM OD 250 is a medication manufactured by Alkem Laboratories Ltd..

• Name:

  • Brand Name: Valkem-OD 250 Tablet, Valkem OD 250 Tablet SR
  • Common Name: Divalproex sodium

• Composition:

  • Each tablet contains Divalproex 250 mg. Divalproex works by increasing the levels of gamma-aminobutyric acid (GABA) in the brain, which helps to reduce excessive and abnormal nerve activity.

• Uses: VALKEM OD 250 is primarily used as an anticonvulsant and mood-stabilizing medicine. It is prescribed for:

  • Epilepsy: Management of various types of seizures, including simple, complex partial, and complex absence seizures.
  • Bipolar Disorder: Regulation of manic episodes associated with bipolar disorder.
  • Migraine Prophylaxis: Prevention of migraine headaches.

• Dosage and Administration:

  • VALKEM OD 250 should be taken as directed by a doctor.
  • Swallow the tablet whole with a glass of water; do not crush or chew it.
  • It can be taken with or without food, but taking it at the same time each day is recommended for optimal results.
  • The dose and frequency are determined by the doctor based on the patient's condition.
  • Do not stop taking the medicine suddenly, as this may worsen symptoms or trigger seizures.

• Side Effects:

  • Common: Drowsiness, dizziness, nausea, headache, back pain, increased appetite, constipation, diarrhoea, fatigue, tremors, blurred vision, abdominal pain, weight gain, tingling sensations, and decreased body temperature.
  • Serious (rare): Liver injury, pancreatitis, thrombocytopenia (low blood platelets), hyperammonemia (high levels of ammonia in the blood), suicidal thoughts, and allergic reactions (e.g., skin rash or redness). Seek immediate medical attention if these occur.

• Precautions:

  • Pregnancy: Not recommended during pregnancy due to the risk of serious birth defects (Pregnancy Category D). Women of childbearing age should use effective contraception.
  • Breastfeeding: Caution is advised as divalproex may pass into breast milk.
  • Alcohol: Avoid consuming alcohol, as it can increase drowsiness and dizziness.
  • Medical Conditions: Inform your doctor if you have liver problems, kidney problems, pancreatitis, blood problems, urea cycle disorders, depression, or suicidal thoughts.
  • Driving/Operating Machinery: Avoid these activities as the medicine may cause drowsiness and dizziness.
  • Monitoring: Regular blood counts and liver/kidney function tests are recommended, especially during the first six months of therapy.

• Storage:

  • Store in a cool and dry place, away from direct sunlight and moisture.
  • Keep out of sight and reach of children.
  • Store below 25°C or 30°C.

Here are frequently asked questions about VALKEM OD 250 by ALKEM LABORATORIES LTD:

What is VALKEM OD 250 used for?

VALKEM OD 250, containing Divalproex sodium, is primarily used to treat epilepsy, which causes seizures or fits. It also helps manage manic episodes associated with bipolar disorder and is prescribed as a preventive measure for migraine headaches.

How does VALKEM OD 250 work?

This medicine works by increasing the levels of a natural chemical in the brain called gamma-aminobutyric acid (GABA). By boosting GABA, VALKEM OD 250 helps to reduce excessive and abnormal nerve activity in the brain, leading to a calming effect that helps control seizures and stabilize mood.

What is the usual dosage for VALKEM OD 250?

The dosage of VALKEM OD 250 is determined by your doctor based on factors like your age, weight, and medical condition. It is recommended to take the tablet at the same time daily, with or without food, for optimal effectiveness. It's crucial not to break, chew, or crush the tablet and to follow your doctor's instructions carefully. For epilepsy, initial doses can be adjusted by 5-10 mg/kg/day weekly until seizures are controlled, potentially up to three times daily.

What are the possible side effects of VALKEM OD 250?

Common side effects can include headache, dizziness, drowsiness, nausea, vomiting, abdominal pain, diarrhea, constipation, increased appetite, tremors, blurred vision, fatigue, unsteadiness, bruising, decreased body temperature, weight gain, back pain, and rash. More serious, but rare, side effects may include liver injury, urinary incontinence, bleeding problems, high ammonia levels in the blood, low body temperature, severe allergic reactions, and even suicidal thoughts. If any side effects persist or worsen, or if you notice a skin rash or redness, consult your doctor immediately.

Is VALKEM OD 250 safe during pregnancy or breastfeeding?

VALKEM OD 250 is generally not recommended during pregnancy as there is definite evidence of risk, and it can lead to serious birth defects. Women of childbearing potential should use effective contraception while taking this medication. If you are pregnant or planning to become pregnant, discontinue the treatment and consult your doctor immediately for a safer alternative. For breastfeeding mothers, caution is advised as Divalproex sodium may pass into breast milk. It is essential to consult your doctor before taking VALKEM OD 250 if you are breastfeeding.

Can VALKEM OD 250 be taken with other medications?

Yes, VALKEM OD 250 can interact with other medications. It is crucial to inform your doctor about all the medicines you are currently taking, including over-the-counter drugs, herbal supplements, and other anti-epileptic medications (e.g., phenytoin, lamotrigine), anti-migraine medicines, antidepressants, painkillers, immunomodulatory medicines, and contraceptives. Interactions can increase the risk of side effects or reduce the effectiveness of either medication.

What precautions should be taken while using VALKEM OD 250?

Do not stop taking VALKEM OD 250 abruptly, as this can worsen your condition and trigger seizures. Discontinuation should always be gradual and under medical supervision. Avoid consuming alcohol while on this medication, as it can increase side effects like dizziness and drowsiness and may enhance the risk of seizures. Due to potential dizziness and drowsiness, avoid driving or operating heavy machinery until you know how the medicine affects you. Inform your doctor if you have a history of liver problems, kidney issues, urea cycle disorders, pancreatitis, blood problems, depression, or suicidal thoughts before starting treatment. Regular blood and liver function tests may be necessary during treatment.

What happens if a dose of VALKEM OD 250 is missed?

If you forget to take a dose of VALKEM OD 250, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one. Missing doses can increase the risk of seizures.

How should VALKEM OD 250 be stored?

VALKEM OD 250 tablets should be stored in a cool and dry place, away from direct sunlight and moisture. The storage temperature should ideally be below 30°C (or between 10ºC to 25ºC). Keep the medicine out of the sight and reach of children and pets.