Zukanorm D 5mg

ZUKANORM D 5MG

ZUKANORM D 5MG, manufactured by Mankind Pharma Ltd, is a prescription medication primarily used for the management of type 2 diabetes mellitus in adults. This combination medicine helps to control high blood sugar levels when diet and exercise alone are insufficient.

• Composition Each tablet of ZUKANORM D 5MG contains Dapagliflozin 5 mg and Vildagliptin 100 mg. Dapagliflozin is a sodium-glucose co-transporter-2 (SGLT-2) inhibitor that works by promoting the excretion of excess glucose from the body through urine. Vildagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that increases the levels of incretin hormones, which, in turn, enhance insulin release and reduce glucagon secretion, thereby lowering blood glucose.

• Uses ZUKANORM D 5MG is prescribed to improve glycemic control in adults with type 2 diabetes mellitus. Beyond blood sugar control, it may also help reduce the risk of heart and worsening kidney disease in individuals with type 2 diabetes.

• Dosage and Administration The dosage of ZUKANORM D 5MG should be strictly followed as prescribed by your healthcare provider. It is typically taken orally, with or without food, preferably at the same time each day to maintain consistent blood sugar levels. Do not crush, chew, or break the tablet. Do not discontinue the medicine without consulting your doctor.

• Side Effects Common side effects may include:

  • Headache
  • Nausea, vomiting, abdominal pain
  • Urinary tract infections (UTIs), female genital mycotic infections
  • Increased urination
  • Low blood sugar (hypoglycemia), especially when used with other antidiabetic medicines
  • Dizziness, tremors
  • Back pain
  • Nasopharyngitis (inflammation of the nose and throat)

  Serious side effects can include muscle pain, fever, swelling, and a tickling/pricking sensation, which could indicate an overdose. Consult your doctor if any side effects persist or worsen.

• Precautions

  • Pregnancy and Breastfeeding: Caution is advised. Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
  • Kidney and Liver Impairment: Not recommended for severe kidney impairment or end-stage renal disease. Caution is advised for patients with liver or kidney health issues.
  • Alcohol: Avoid consuming alcohol while on this medication as it may increase the risk of hypoglycemia and lactic acidosis.
  • Drug Interactions: Inform your doctor about all other medications, herbs, or supplements you are taking to avoid possible interactions. Interactions can occur with oral hypoglycemic agents (e.g., insulin secretagogues like glimepiride), diuretics (e.g., furosemide), and ACE inhibitors, potentially increasing the risk of hypoglycemia, dehydration, low blood pressure, or angioedema respectively.
  • Driving and Operating Machines: If you experience dizziness, avoid driving or operating machinery.
  • Children: Not recommended for children as safety and effectiveness have not been established.

• Storage Store ZUKANORM D 5MG in a cool, dry place, away from direct sunlight and moisture, and below 30°C. Keep it out of the reach of children and pets.

What is ZUKANORM D 5MG used for?

ZUKANORM D 5MG is an anti-diabetic medication used to manage Type 2 Diabetes Mellitus in adults, alongside a healthy diet and regular exercise. It helps control high blood sugar levels and can also contribute to reducing the risk of worsening heart and kidney disease.

How does ZUKANORM D 5MG work?

This medicine contains two active ingredients: Dapagliflozin and Vildagliptin. Dapagliflozin works by inhibiting a specific protein in the kidneys (SGLT-2), which prevents glucose from being reabsorbed back into the blood, leading to the elimination of sugar through urine. Vildagliptin enhances the body's natural hormones (incretins) that are released in response to food intake, thereby increasing insulin secretion and decreasing glucagon, which helps lower blood sugar levels.

What is the usual dosage of ZUKANORM D 5MG?

The usual dosage of ZUKANORM D 5MG should be strictly followed as prescribed by your doctor. It is typically taken orally, with or without food, preferably at the same time each day to maintain consistent blood sugar levels. Do not exceed the prescribed dose or stop taking this medicine without your doctor's advice.

What are the possible side effects of ZUKANORM D 5MG?

Common side effects may include headache, dizziness, low blood sugar (hypoglycemia), shakiness, nausea, vomiting, abdominal pain, frequent urination, and urinary tract infections. Some people may also experience female genital mycotic infections, nasopharyngitis (inflammation of the nose and throat), back pain, dyslipidemia, fatigue, rash, and tremors. If any side effects persist or worsen, consult your doctor.

Is ZUKANORM D 5MG safe during pregnancy or breastfeeding?

ZUKANORM D 5MG should generally not be used during pregnancy unless specifically recommended by your doctor, as there is limited information on its use, and some animal studies have shown adverse effects. For breastfeeding mothers, it is also generally not recommended, as components of the medicine may pass into breast milk and could cause drowsiness in the newborn. Always consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Can ZUKANORM D 5MG be taken with other medications?

ZUKANORM D 5MG can interact with other medications. It is crucial to inform your doctor about all other medicines, herbal products, or supplements you are currently taking or plan to take.

• Diuretics (e.g., furosemide, hydrochlorothiazide) may increase the risk of dehydration and low blood pressure.
• Insulin and insulin secretagogues (e.g., glimepiride, glipizide) may cause extremely low blood sugar levels.
• ACE inhibitors may increase the risk of angioedema.
• Corticosteroids, thyroxine, and certain CNS-acting medicines can reduce the effectiveness of ZUKANORM D.
• Gatifloxacin may affect blood glucose levels.

What precautions should be taken while using ZUKANORM D 5MG?

Inform your doctor if you have allergies to any of its ingredients. Exercise caution if you have kidney disease (it's not recommended for moderate to severe impairment), liver disease, heart failure, or a history of pancreatitis. Regular monitoring of blood sugar levels is essential. ZUKANORM D 5MG may cause dizziness, so avoid driving or operating heavy machinery until you know how the medicine affects you. It is advisable to limit or avoid alcohol consumption, as it can increase the risk of low blood sugar and other side effects. Maintaining good hygiene can help prevent genital fungal infections.

What happens if a dose of ZUKANORM D 5MG is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should ZUKANORM D 5MG be stored?

Store ZUKANORM D 5MG in a cool and dry place, away from direct sunlight and moisture. Keep it out of the reach of children and pets. It should be stored at room temperature, generally between 25°C to 30°C.