Clodrel Plus Tablet (15 Tab)

CLODREL PLUS TABLET is a medication manufactured by Torrent Pharmaceuticals Ltd., commonly referred to by its brand name, Clodrel Plus.

Composition

Clodrel Plus Tablet contains a combination of two antiplatelet medicines: Aspirin (75 mg) and Clopidogrel (75 mg). These ingredients work as blood thinners to prevent the formation of harmful blood clots in blood vessels.

Uses

This medication is primarily prescribed to reduce the formation of harmful blood clots and is used for the prevention of heart attack and stroke. It is also used in the treatment of acute coronary syndrome (ACS), coronary artery disease, and peripheral arterial disease.

Dosage and Administration

Clodrel Plus Tablet should be taken orally, typically once daily, as advised by your doctor. It is recommended to take it with food to avoid stomach upset. The tablet should be swallowed whole with a glass of water and not chewed, crushed, or broken. Do not stop taking this medicine without consulting your doctor.

Side Effects

Common side effects may include abdominal pain, indigestion, diarrhea, easy bruising, and nosebleeds due to an increased risk of bleeding. More serious, though less common, side effects can include gastrointestinal bleeding, black tarry stools, or blood in the urine, and in rare cases, signs of stroke. Dizziness and blurry vision are also reported.

Precautions

Clodrel Plus Tablet increases the risk of bleeding, so caution should be exercised with activities like shaving or using sharp objects. Alcohol consumption is generally discouraged as it can increase the risk of stomach bleeding. It is not recommended during pregnancy and is probably unsafe during breastfeeding; consult your doctor if pregnant, planning pregnancy, or breastfeeding. Patients with liver or kidney diseases, bleeding disorders, stomach ulcers, or asthma should use this medicine with caution and inform their doctor. Avoid taking NSAIDs like ibuprofen without consulting your doctor, as this may increase the risk of stomach ulcers and bleeding.

Storage

Store Clodrel Plus Tablet in a cool and dry place, away from direct sunlight and moisture, and out of sight and reach of children. It should be stored at temperatures between 10ºC to 25ºC or below 30ºC.

CLODREL PLUS TABLET (15 TAB) by TORRENT PHARMACEUTICALS LTD. is a combination medication containing Aspirin (75mg) and Clopidogrel (75mg). It is primarily used to prevent blood clots, thereby reducing the risk of heart attack and stroke.

What is CLODREL PLUS TABLET used for?

CLODREL PLUS TABLET is used to prevent heart attacks and strokes in individuals with heart conditions. It is also prescribed to treat acute coronary syndrome (ACS), prevent blood clots in patients with heart conditions, and reduce the risk of stroke in those with a history of stroke or peripheral arterial disease.

How does CLODREL PLUS TABLET work?

CLODREL PLUS TABLET contains two antiplatelet medicines, Aspirin and Clopidogrel. They work by preventing platelets (blood cells) from sticking together and forming harmful blood clots in blood vessels. Aspirin specifically blocks an enzyme called cyclooxygenase (COX), which is involved in clot formation, while Clopidogrel inhibits platelet aggregation by blocking the activity of ADP. This action helps maintain smooth blood flow and reduces the risk of cardiovascular events.

What is the usual dosage of CLODREL PLUS TABLET?

CLODREL PLUS TABLET is typically taken once daily, preferably with food to help reduce stomach upset. It should be swallowed whole with a glass of water and not chewed, crushed, or broken. The exact dosage and duration will be determined by a doctor based on the patient's medical condition.

What are the possible side effects of CLODREL PLUS TABLET?

Common side effects of CLODREL PLUS TABLET include abdominal pain, indigestion, diarrhea, easy bruising, and nosebleeds. Other potential side effects can include nausea, vomiting, stomach pain, and headache. These side effects often resolve over time, but if they persist or worsen, medical attention should be sought. Serious side effects may include unusual or prolonged bleeding, black tarry stools, or blood in the urine.

Is CLODREL PLUS TABLET safe during pregnancy or breastfeeding?

CLODREL PLUS TABLET is generally not recommended for use during pregnancy as there is evidence of risk to the developing baby. It is also probably unsafe to use during breastfeeding because its components can pass into breast milk and may pose a significant risk to the baby. Pregnant or breastfeeding women should consult their physician to weigh the benefits and potential risks before taking this medication.

Can CLODREL PLUS TABLET be taken with other medications?

CLODREL PLUS TABLET can interact with several other medications, increasing the risk of side effects like bleeding. It is important to inform your doctor about all prescription and non-prescription medicines, vitamins, nutritional supplements, and herbal products you are taking. Notable interactions include:

• Other anticoagulants (e.g., warfarin, heparin) and NSAIDs (e.g., ibuprofen, paracetamol), which can increase the risk of bleeding.
• Antacids and proton-pump inhibitors (e.g., omeprazole), which may affect its efficacy or increase the risk of gastrointestinal issues.
• Methotrexate, used in cancer treatment, as aspirin can increase its serum levels.

What precautions should be taken with CLODREL PLUS TABLET?

Several precautions should be taken while on CLODREL PLUS TABLET:

• Bleeding Risk: The medication increases the risk of bleeding. Patients should be careful with activities that may cause injury and inform their doctor before any surgical or dental procedures.
• Alcohol: Avoid consuming alcohol, as it can increase the risk of stomach bleeding.
• Medical Conditions: Caution is advised for patients with liver or kidney disease, bleeding disorders (like hemophilia), stomach ulcers, or a history of respiratory problems such as asthma or nasal polyps.
• Driving: CLODREL PLUS TABLET may cause dizziness or blurry vision, so driving or operating machinery should be avoided if these symptoms occur.
• Do not stop abruptly: Do not stop taking the medicine without consulting your doctor, as this can worsen your condition and increase the risk of a heart attack or stroke.

What happens if a dose is missed?

If a dose of CLODREL PLUS TABLET is missed, it should be taken as soon as remembered. However, if it is almost time for the next scheduled dose, the missed dose should be skipped, and the regular dosing schedule resumed. Do not double the dose to compensate for a missed one, as this can increase the risk of side effects.

How should CLODREL PLUS TABLET be stored?

CLODREL PLUS TABLET should be stored in a cool and dry place, away from direct sunlight and moisture. It should also be kept out of sight and reach of children. The recommended storage temperature is between 10ºC and 30ºC.