Huminsulin 30/70 Injection 40 Iu 10ml (vial)

HUMINSULIN 30/70 INJECTION 40 IU 10ML (VIAL) by LUPIN LTD.

Name

• Common Name: Human Insulin Isophane Suspension (30% Soluble Insulin / 70% Isophane Insulin)
• Brand Name: HUMINSULIN 30/70

Composition HUMINSULIN 30/70 contains a premixed formulation of human insulin:

• 30% Soluble Human Insulin (rapid-acting)
• 70% Isophane Human Insulin (intermediate-acting) Each 10 ml vial contains 40 International Units (IU) of insulin per milliliter.

Uses HUMINSULIN 30/70 is prescribed for the management of:

• Type 1 Diabetes Mellitus: Where the body does not produce enough insulin.
• Type 2 Diabetes Mellitus: To improve blood sugar control in adults and children. This medicine works by facilitating the uptake of glucose into muscle and fat cells and inhibiting glucose production in the liver, thereby helping to control blood sugar levels.

Dosage and Administration

• HUMINSULIN 30/70 is administered via subcutaneous injection into areas such as the upper arms, thighs, buttocks, or abdomen.
• It is typically injected 15-30 minutes before a meal, usually once or twice daily.
• The exact dosage is determined by a healthcare professional based on individual patient needs, blood glucose monitoring, and overall health status.
• Rotation of injection sites is crucial to prevent lipodystrophy (thickening or pitting of the skin at the injection site), which can affect insulin absorption.
• Do not administer intravenously.
• Never share an injection pen, cartridge, or syringe with another person.

Side Effects Common side effects may include:

• Hypoglycemia (low blood sugar), characterized by symptoms like headache, hunger, sweating, dizziness, shakiness, and trouble concentrating.
• Injection site reactions (pain, redness, itching, swelling).
• Lipodystrophy (skin thickening or pitting at the injection site).
• Weight gain.
• Oedema (swelling in hands or feet).

Serious side effects, though rare, can include:

• Severe allergic reactions (e.g., skin rash over the entire body, difficulty breathing, wheezing, swelling of face/throat).
• Hypokalemia (low blood potassium levels).
• Heart failure, especially if used with thiazolidinediones.

Precautions

• Hypoglycemia: Patients should be aware of the symptoms of low blood sugar and always carry a source of fast-acting sugar.
• Allergies: Do not use if allergic to insulin or any of its components.
• Medical Conditions: Use with caution in patients with kidney, liver, or heart problems. Dose adjustment may be necessary.
• Diabetic Ketoacidosis: Not recommended for the treatment of diabetic ketoacidosis due to its delayed onset of action.
• Pregnancy and Breastfeeding: Consult a doctor, as dose adjustments may be needed. Generally considered safe.
• Alcohol Consumption: Alcohol may affect blood glucose levels and should be used with caution or avoided.
• Driving and Operating Machinery: May cause blurred vision or dizziness; exercise caution when performing such activities.
• Insulin Changes: Any change in insulin type or brand should only be done under strict medical supervision.
• Blood Glucose Monitoring: Regular monitoring of blood glucose levels is essential for effective diabetes management and dose adjustment.

Storage

• Unopened Vials: Store in a refrigerator between 2°C and 8°C (36°F to 46°F). Do not freeze.
• Opened/In-Use Vials: Can be stored at room temperature (below 30°C or up to 25°C) for up to 28 days.
• Protect from direct sunlight and excessive heat.
• Discard the vial after 28 days of first use, even if there is insulin remaining.
• Keep out of reach of children and pets.

What is Huminsulin 30/70 Injection used for?

Huminsulin 30/70 Injection is a combination medicine primarily used to treat both Type 1 and Type 2 diabetes mellitus. It helps to improve blood sugar control in adults and children with diabetes.

How does Huminsulin 30/70 Injection work?

This medicine is a premixed formulation containing 30% short-acting (soluble) insulin and 70% intermediate-acting (isophane) insulin. It works by stimulating the uptake of sugar by muscle and fat cells and by suppressing the production of sugar in the liver, thereby ensuring rapid and consistent blood sugar control. The short-acting component helps manage post-meal blood sugar spikes, while the intermediate-acting component provides longer-lasting blood sugar control between meals.

What is the usual dosage for Huminsulin 30/70 Injection?

The dosage of Huminsulin 30/70 Injection is highly individualized and determined by your doctor based on your metabolic needs, blood glucose monitoring results, and glycemic control goals. It is typically administered via subcutaneous injection (under the skin) approximately 30 to 45 minutes before a meal. It's crucial to follow your doctor's exact instructions regarding the dose and timing.

What are the possible side effects of Huminsulin 30/70 Injection?

The most common side effect is low blood sugar (hypoglycemia), which can cause symptoms like sweating, shakiness, headache, hunger, confusion, dizziness, blurred vision, and a fast heartbeat. Other common side effects include allergic reactions at the injection site, itching, rash, skin thickening or pits at the injection site (lipodystrophy), swelling (oedema), and weight gain. More serious side effects can include severe allergic reactions and hypokalemia (low potassium levels). If you experience persistent or severe side effects, consult your doctor.

Is Huminsulin 30/70 Injection safe during pregnancy or breastfeeding?

Huminsulin 30/70 Injection is generally considered safe for use during pregnancy and breastfeeding if prescribed by a doctor. However, it is essential to maintain good blood glucose control throughout pregnancy, and insulin needs may change during this time and while breastfeeding. Always consult your doctor if you are pregnant, planning pregnancy, or breastfeeding.

Can Huminsulin 30/70 Injection be taken with other medications?

Huminsulin 30/70 Injection can interact with various medications, which may either increase or decrease its blood glucose-lowering effect. It's crucial to inform your doctor about all current medications, including over-the-counter drugs, herbal supplements, and vitamins, to avoid potential interactions. Alcohol consumption should be avoided or limited as it can increase the risk of hypoglycemia and mask its symptoms. Smoking tobacco can also affect insulin resistance and blood glucose levels.

What precautions should be taken while using Huminsulin 30/70 Injection?

Regular monitoring of your blood sugar levels is essential. Do not share injection pens, cartridges, or syringes with other people. Rotate injection sites within the recommended areas (upper arms, thighs, buttocks, or abdomen) to prevent skin changes like lipodystrophy. Exercise caution if you have kidney or liver problems, as your doctor may need to adjust your dose. Be aware of the symptoms of hypoglycemia, and always carry a fast-acting source of sugar. Huminsulin 30/70 can cause drowsiness, so drive or operate machinery only if you are alert.

What happens if a dose of Huminsulin 30/70 Injection is missed?

If you miss a dose of Huminsulin 30/70 Injection and remember it shortly after your meal (e.g., within 1-2 hours), you may be able to administer it. However, if a significant amount of time has passed and it's close to your next scheduled dose, it's generally advised to skip the missed dose and resume your regular dosing schedule. Never take a double dose to make up for a missed one. Monitor your blood sugar levels more frequently after a missed dose and consult your doctor if you have concerns or your blood sugar becomes too high.

How should Huminsulin 30/70 Injection be stored?

Unopened vials of Huminsulin 30/70 should be stored in a refrigerator between 2°C and 8°C (36°F to 46°F). Do not freeze the medicine, and do not use it if it has been frozen. Once opened, vials can typically be stored at room temperature (below 30°C or 86°F) away from heat and direct light for a limited period, usually up to 31 days or 28 days, depending on the specific product and manufacturer's instructions. Always check the specific storage instructions on the product packaging and discard any opened vials after the recommended period, even if some medicine remains.