Lupisit Gm 1/1000

LUPISIT GM 1/1000 Tablet by Lupin Ltd.

LUPISIT GM 1/1000 Tablet is a combination anti-diabetic medication manufactured by Lupin Ltd., designed to effectively manage blood glucose levels in adults with Type 2 Diabetes Mellitus. It is typically prescribed when diet, exercise, and single-agent treatments are insufficient to control blood sugar.

• Name:

  • Brand Name: LUPISIT GM 1/1000 Tablet
  • Manufacturer: Lupin Ltd.

• Composition: LUPISIT GM 1/1000 Tablet contains a combination of three active ingredients:

  • Sitagliptin: 50 mg
  • Glimepiride: 1 mg
  • Metformin: 1000 mg

• Uses: This medicine is used for the management of Type 2 Diabetes Mellitus. It works to:

  • Control elevated blood sugar levels.
  • Improve glycemic control throughout the day, including after meals and during fasting.
  • Enhance insulin function by increasing insulin sensitivity and encouraging the pancreas to release insulin.
  • Reduce glucose production by the liver.
  • Help prevent diabetes-related complications such as nerve damage, kidney issues, eye problems, and heart conditions.

• Dosage and Administration: LUPISIT GM 1/1000 Tablet should be taken orally with food, precisely as directed by a healthcare professional. It is important to adhere to the prescribed dosage and frequency. The tablets should be swallowed whole and not crushed, broken, or chewed. Regular monitoring of blood sugar levels is advised during treatment.

• Side Effects: Common side effects may include:

  • Hypoglycemia (low blood sugar)
  • Nausea, vomiting, diarrhea
  • Abdominal pain/gastrointestinal disturbances
  • Headache Less common but serious side effects can include lactic acidosis, inflammation of the liver (jaundice), and severe allergic reactions.

• Precautions:

  • Contraindications: Not recommended for patients with Type 1 Diabetes Mellitus, diabetic ketoacidosis, or severe liver or kidney disease.
  • Organ Impairment: Use with caution in patients with liver or kidney impairment; dose adjustments may be necessary.
  • Alcohol: Avoid alcohol consumption as it increases the risk of hypoglycemia and lactic acidosis.
  • Pregnancy & Breastfeeding: Consult a doctor, as its use may be unsafe or not recommended during these periods.
  • Pediatric Use: Not recommended for children under 18 years of age.
  • Drug Interactions: Inform your doctor about all other medications being taken, including corticosteroids, calcium channel blockers, and sympathomimetics, as interactions can occur.
  • Elderly Patients: May require dose adjustments and close monitoring due to increased sensitivity.

• Storage: Store LUPISIT GM 1/1000 Tablet in a cool and dry place, preferably below 25°C or 30°C. Protect from direct sunlight and moisture. Keep the medicine out of the sight and reach of children. Store in its original packaging.

Here are the most frequently asked questions about LUPISIT GM 1/1000, along with concise and accurate answers:

What is LUPISIT GM 1/1000 used for?

LUPISIT GM 1/1000 Tablet is used to manage type 2 diabetes mellitus in adults. It is prescribed when diet, exercise, and treatment with a single antidiabetic agent do not adequately control blood sugar levels. This medicine helps lower blood sugar levels, improve insulin response, and reduce the risk of diabetes-related complications such as nerve damage, kidney issues, and heart conditions.

How does LUPISIT GM 1/1000 work?

LUPISIT GM 1/1000 is a combination medicine containing three active ingredients: Glimepiride, Metformin, and Sitagliptin.

• Glimepiride (a sulfonylurea) works by stimulating the pancreas to release more insulin, which helps lower blood glucose levels.
• Metformin (a biguanide) decreases the amount of glucose produced by the liver, reduces glucose absorption from the intestines, and improves the body's sensitivity to insulin.
• Sitagliptin (a Dipeptidyl peptidase-4 (DPP-4) inhibitor) helps control blood sugar levels by increasing the levels of natural substances called incretins, which make the pancreas release more insulin and signal the liver to stop producing sugar when levels are high.

What is the usual dosage of LUPISIT GM 1/1000?

LUPISIT GM 1/1000 should be taken exactly as prescribed by your doctor. The dosage may vary based on your blood sugar levels and how you respond to the treatment. It is best taken with food to reduce the chance of an upset stomach. Do not change your dose without consulting your healthcare provider.

What are the possible side effects of LUPISIT GM 1/1000?

Common side effects include taste disturbance, nausea, diarrhea, stomachache, vomiting, abdominal pain, headache, and hypoglycemia (low blood sugar level). Serious side effects, though rare, can include lactic acidosis (symptoms like vomiting, bellyache with muscle cramps, severe tiredness, low heartbeat, and difficulty breathing), severe allergic reactions, and inflammation of the liver (jaundice). Contact your doctor if any side effects worsen or persist.

Is LUPISIT GM 1/1000 safe during pregnancy or breastfeeding?

LUPISIT GM 1/1000 is generally not recommended for use during pregnancy as it may be unsafe and animal studies have shown harmful effects on the developing baby. Similarly, it is generally not recommended for breastfeeding women as it may pass into breast milk. Always consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding before taking this medicine.

Can LUPISIT GM 1/1000 be taken with other medications?

There are potential drug interactions with LUPISIT GM 1/1000. It is crucial to inform your doctor about all other medicines, herbal products, or supplements you are taking to avoid possible interactions. Examples of medications that may interact include imidazoles (like miconazole), antibiotics (like rifampin), diuretics (like furosemide), corticosteroids, certain anti-convulsants (like phenytoin), and insulin or other insulin secretagogues.

What precautions should be taken while using LUPISIT GM 1/1000?

• Alcohol: Avoid consuming alcohol as it can increase the risk of low blood sugar and lactic acidosis, a rare but serious condition.
• Medical Conditions: This medicine is not recommended for patients with type 1 diabetes mellitus, diabetic ketoacidosis, severe liver or kidney disease, or acute heart problems.
• Children and Elderly: LUPISIT GM 1/1000 is generally not suitable for children and adolescents under 18 years of age. Elderly patients may require dose adjustments due to increased sensitivity and a higher risk of low blood sugar.
• Driving: Be careful while driving or operating machinery, as low blood sugar can affect concentration and reaction time.
• Monitoring: Regular monitoring of blood sugar levels is essential to ensure optimal diabetes management.

What happens if a dose of LUPISIT GM 1/1000 is missed?

If you forget to take a dose of LUPISIT GM 1/1000, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should LUPISIT GM 1/1000 be stored?

LUPISIT GM 1/1000 tablets should be stored below 25°C or at room temperature (20-25°C). Keep the medicine out of the sight and reach of children and protect it from moisture and light.