Amazeo Od 100 Mg Tablet (10 Tab)

AMAZEO OD 100 MG TABLET (10 TAB)

Name

• Brand Name: Amazeo OD 100 Tablet SR
• Common Name: Amisulpride (Sustained Release/Once Daily)

Composition

• Active Ingredient: Amisulpride 100 mg
• Manufacturer: Torrent Pharmaceuticals Ltd.

Uses Amazeo OD 100 Tablet SR is an antipsychotic medication primarily used for the treatment of:

• Schizophrenia: It manages acute and chronic schizophrenic disorders, addressing both positive symptoms (such as delusions, hallucinations, and thought disorders) and negative symptoms (like blunted affect, emotional and social withdrawal). It works by balancing certain natural substances, particularly by blocking dopamine receptors in the brain to correct overactivity.
• Postoperative Nausea and Vomiting (PONV): It also possesses anti-emetic properties and can be prescribed to prevent or treat nausea and vomiting after surgery.

Dosage and Administration

• Amazeo OD 100 Tablet SR should be taken exactly as prescribed by your doctor.
• Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
• It can be taken with or without food, but it is recommended to take it at the same time each day for consistent levels in the body.
• Doses up to 300 mg can be taken once daily, preferably before bedtime to minimize daytime drowsiness. Doses exceeding 300 mg are often split between morning and evening.
• Do not stop taking this medication suddenly without consulting your doctor, as it may worsen symptoms or lead to withdrawal effects.

Side Effects Common Side Effects:

• Nausea, vomiting, dry mouth
• Constipation
• Weight gain
• Decreased blood pressure, leading to dizziness and sleepiness
• Dystonia (involuntary muscle contractions), akathisia (inability to stay still), parkinsonism
• Increased prolactin levels in the blood, which can lead to unusual breast milk production (in both men and women), breast pain, breast enlargement in men, or absence of menstrual periods
• Blurred vision
• Difficulty sleeping (insomnia), feeling anxious or agitated
• Erectile dysfunction

Serious Side Effects (Seek immediate medical attention if experienced):

• Signs of an allergic reaction (difficulty swallowing/breathing due to swelling of hands, feet, face, lips or throat; itchy, lumpy rash)
• Fits or seizures
• Signs of neuroleptic malignant syndrome (high temperature, sweating, stiff muscles, fast heartbeat/breathing, feeling confused, drowsy, agitated)
• Indications of heart issues or abnormal heart rhythm
• Blood clots in veins
• Severe liver complications

Precautions

• Contraindications: Do not take if you are allergic to amisulpride or any of its ingredients. It is not recommended for children and adolescents under 15 or 18 years of age due to undetermined safety. Avoid if you have breast cancer or a prolactin-dependent tumor, pheochromocytoma (tumor of the adrenal gland), or a pituitary tumor.
• Pregnancy and Breastfeeding: Amazeo OD 100 Tablet SR is not recommended during pregnancy and in breastfeeding women. Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding.
• Elderly Patients: Use with extreme caution in elderly patients (over 65 years of age) due to an increased risk of severe adverse effects, including hypotension or sedation.
• Medical Conditions: Inform your doctor if you have kidney disease, liver disease, epilepsy/fits, Parkinson's disease, heart rhythm disorders (including prolonged QT interval), low potassium levels, diabetes, a history of stroke, blood clots, or a low white blood cell count.
• Alcohol Consumption: Avoid or limit alcohol consumption during treatment as it may worsen side effects like drowsiness and dizziness.
• Driving and Operating Machinery: This medicine may cause dizziness and drowsiness, so avoid driving or operating heavy machinery until you know how it affects you.
• Metabolic Changes: Amazeo OD 100 Tablet SR can lead to weight gain and may increase blood sugar, cholesterol, and triglyceride levels. Lifestyle modifications such as a healthy diet and regular exercise are recommended.

Storage

• Store below 30°C.
• Protect from light and moisture.
• Keep out of the sight and reach of children.

Frequently Asked Questions (FAQs) about Amazeo OD 100 MG Tablet

What is Amazeo OD 100 MG Tablet used for?

Amazeo OD 100 MG Tablet, containing Amisulpride, is primarily used to treat schizophrenia, a mental disorder affecting a person's thoughts, feelings, and behavior. It helps manage both positive symptoms like delusions, hallucinations, and thought disorders, as well as negative symptoms such as emotional and social withdrawal. Additionally, it is used to prevent and treat postoperative nausea and vomiting.

How does Amazeo OD 100 MG Tablet work?

Amazeo OD 100 MG Tablet is an atypical antipsychotic. It works by modulating the action of certain chemical messengers, specifically by blocking dopamine D2 receptors in the brain. This action helps to correct dopamine overactivity, which is associated with schizophrenia, thereby producing a calming effect and improving thoughts, feelings, and behavior. It also inhibits receptors that induce vomiting, providing its anti-emetic properties.

What is the usual dosage for Amazeo OD 100 MG Tablet?

The dosage of Amazeo OD 100 MG Tablet is determined by your doctor based on your medical condition. For acute psychotic episodes, oral doses typically range between 400 mg/day and 800 mg/day, and in some cases, may be increased up to 1200 mg/day. Doses up to 300 mg can be taken once daily, preferably at the same time each day, while doses exceeding 300 mg may be split into morning and evening doses. The tablet should be swallowed whole with or without food, but preferably before bedtime to avoid daytime sleepiness. It should not be crushed, chewed, or broken.

What are the possible side effects of Amazeo OD 100 MG Tablet?

Common side effects include nausea, vomiting, dry mouth, constipation, weight gain, dizziness, sleepiness, blurred vision, insomnia (difficulty sleeping), and erectile dysfunction. It may also cause a sudden drop in blood pressure, so it's advisable to rise slowly. Other reported side effects include involuntary muscle contractions (dystonia, akathisia), increased prolactin levels in the blood, and increased blood sugar and cholesterol levels. More serious side effects that require immediate medical attention include signs of an allergic reaction (difficulty swallowing/breathing, swelling), fits or seizures, signs of neuroleptic malignant syndrome (high temperature, sweating, stiff muscles, fast heartbeat, confusion), and blood clots.

Is Amazeo OD 100 MG Tablet safe during pregnancy or breastfeeding?

Amazeo OD 100 MG Tablet is generally not recommended and may be unsafe to use during pregnancy, especially in the last trimester, as animal studies have shown harmful effects on the developing baby. It is also considered unsafe and not recommended during breastfeeding, as the medicine may pass into breast milk. Always consult your doctor before taking this medicine if you are pregnant, planning to conceive, or breastfeeding.

Can Amazeo OD 100 MG Tablet be taken with other medications?

It is crucial to inform your doctor about all medications you are currently taking, including over-the-counter drugs and herbal supplements, to avoid potential drug interactions. Amazeo OD 100 MG Tablet is generally not recommended with:

• Levodopa (for Parkinson's disease) as they have opposing effects.
• Other antipsychotics, antidepressants, or anti-seizure medicines, as this can lead to severe side effects.
• Medicines that affect heart rhythm (e.g., quinidine, disopyramide, amiodarone, sotalol) or lower heart rate (e.g., beta-blockers, diltiazem, verapamil), as it can increase the risk of irregular heart rhythms.
• Alcohol, as it may worsen side effects like drowsiness and dizziness. Be cautious with sedatives, antimalarial medicines (like mefloquine), and antihistamines, as they can also cause drug interactions.

What precautions should be taken while taking Amazeo OD 100 MG Tablet?

• Driving and Operating Machinery: This medicine can cause dizziness, drowsiness, and blurred vision, so avoid driving or operating heavy machinery until you know how it affects you.
• Blood Pressure: Initially, it may cause a sudden drop in blood pressure when changing positions, so rise slowly.
• Alcohol: Avoid consuming alcohol, as it can worsen side effects.
• Medical Conditions: Inform your doctor if you have kidney or liver disease, diabetes, Parkinson's disease, epilepsy/seizures, heart problems, breast cancer or prolactin-dependent tumors, adrenal gland tumors (pheochromocytoma), or a history of blood clots.
• Children and Elderly: It is not recommended for children under 15 or 18 years of age due to unestablished safety. Use with caution in elderly patients (above 65 years) due to an increased risk of severe adverse effects like hypotension or sedation.
• Stopping Treatment: Do not stop taking Amazeo OD 100 MG Tablet suddenly without consulting your doctor, as abrupt discontinuation can lead to withdrawal symptoms (nausea, vomiting, sweating, difficulty sleeping, restlessness, muscle stiffness) or a worsening of your original condition. Your doctor will advise a gradual dose reduction.

What happens if a dose of Amazeo OD 100 MG Tablet is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

How should Amazeo OD 100 MG Tablet be stored?

Amazeo OD 100 MG Tablet should be stored at room temperature, ideally below 30°C. Keep it in a cool, dry place and protect it from light and moisture. Keep it out of the sight and reach of children.