Sustanon 250 Mg Injection

SUSTANON 250 MG INJECTION by ZYDUS CADILA

Name

Brand Name: Sustanon 250 Injection Common Name: Testosterone esters injection (a combination of four testosterone esters)

Composition

Each 1 mL ampoule or vial of Sustanon 250 contains a total of 250 mg of testosterone, delivered through four distinct testosterone esters:

• Testosterone Propionate: 30 mg
• Testosterone Phenylpropionate: 60 mg
• Testosterone Isocaproate: 60 mg
• Testosterone Decanoate: 100 mg

Inactive Ingredients: Arachis (peanut) oil (base) and benzyl alcohol (preservative).

Uses

Sustanon 250 Injection is primarily used for androgen replacement therapy in males with confirmed testosterone deficiency, also known as male hypogonadism. This condition can manifest as:

• Delayed puberty
• Impotence or erectile dysfunction
• Low libido (low sex drive)
• Infertility due to sperm production disorders
• Loss of bone mass (osteoporosis) caused by androgen deficiency
• Tiredness and depression associated with low testosterone levels

It is also used as supportive therapy for masculinization in female-to-male transsexuals.

Dosage and Administration

Sustanon 250 is administered by deep intramuscular injection. The usual recommended dose for adults, including the elderly, is one 1 mL injection every three weeks. The dosage may be adjusted by a doctor based on individual patient requirements and response to treatment. This medicine should only be administered by a doctor or nurse.

Side Effects

Common Side Effects:

• Pain at the injection site
• Acne, oily skin
• Nausea
• Muscle pain
• Increased weight
• High blood pressure
• Increased or decreased libido
• Fluid retention (oedema, swelling of ankles and feet)
• Enlargement of breasts in men (gynaecomastia)
• Prostate enlargement or increased PSA levels
• Disturbed sperm formation, or a size reduction of testes
• Hair loss, body and facial hair growth
• Changes in blood test results (e.g., increased red blood cell count, haemoglobin, haematocrit, changes in cholesterol levels, altered liver function tests)
• Mood disturbances, depression, nervousness, irritability
• Difficulty sleeping, headache, flushing

Serious Side Effects (seek immediate medical attention):

• Signs of an allergic reaction (e.g., itching, rashes, swelling of lips or face, difficulty breathing)
• Yellowing of the skin and eyes (jaundice)
• Prolonged, abnormal, painful erection of the penis (priapism)
• Growth of undetected prostate cancer
• Coughing, increased sweating, chest pain, feeling faint
• Pain, swelling, redness, and enlarged veins in the affected area (blood clots)

Precautions

• Allergies: Contraindicated in patients with known hypersensitivity to the active substances, arachis oil (peanut oil), or soya.
• Cancers: Not recommended for use in patients with known or suspected prostate cancer or male breast cancer.
• Children: Not to be given to children under 3 years of age due to the presence of benzyl alcohol, which can cause toxic reactions. Pre-pubertal children receiving this medicine should be monitored carefully for accelerated growth and sexual development.
• Medical Conditions: Use with caution in patients with heart problems (may cause high blood pressure, fluid retention), polycythemia, hypercalcaemia, diabetes (may alter blood sugar levels), and liver or kidney problems.
• Interactions: May interfere with anticoagulants (blood thinners), anti-diabetic medicines (like insulin), adrenocorticotrophic hormone (ACTH), and corticosteroids. Regular monitoring of testosterone levels, prostate-specific antigen (PSA), haematocrit, haemoglobin, and liver function is recommended.
• Women: Not indicated for use in women, especially during pregnancy or breastfeeding, due to the risk of virilization of the fetus or infant.
• Sleep Apnoea: May worsen sleep apnoea in individuals with risk factors like obesity or chronic lung disease.
• Abuse: Misuse of androgens to enhance athletic performance carries serious health risks and is discouraged.

Storage

Sustanon 250 Injection should be stored at or below 30°C. Do not refrigerate or freeze. Keep it in the original box to protect it from light and out of reach and sight of children. Once an ampoule is opened, the solution should be used immediately as it cannot be resealed to guarantee sterility.

Here are some frequently asked questions and answers about Sustanon 250 mg Injection:

What is Sustanon 250 mg Injection used for?

Sustanon 250 mg Injection is primarily used for testosterone replacement therapy in adult males with confirmed testosterone deficiency, a condition known as male hypogonadism. It helps to alleviate symptoms such as low sex drive, erectile dysfunction, fatigue, depressive moods, and loss of bone mass or muscle mass. It can also be used as supportive therapy for masculinization in female-to-male transsexuals and in cases of delayed puberty in boys.

How does Sustanon 250 mg Injection work?

Sustanon 250 mg Injection contains a blend of four different testosterone esters: testosterone propionate, testosterone phenylpropionate, testosterone isocaproate, and testosterone decanoate. These esters are gradually converted into natural testosterone by the body. This unique combination provides both an immediate and sustained release of testosterone into the bloodstream, helping to restore and maintain healthy testosterone levels and hormonal balance.

What is the usual dosage of Sustanon 250 mg Injection?

The standard dosage for Sustanon 250 mg Injection is typically one 1 mL injection every three weeks. The injection is administered deeply into a muscle, such as the buttock, upper leg, or upper arm, by a doctor or nurse. Your doctor will adjust the dosage based on your individual testosterone levels and medical needs.

What are the possible side effects of Sustanon 250 mg Injection?

Common side effects can include pain at the injection site, itching, acne, nausea, muscle pain, increased weight, high blood pressure, changes in sexual desire (libido), disturbed sperm formation (which can affect fertility in men), breast enlargement in men (gynecomastia), and fluid retention (swelling of ankles and feet). Other less common side effects may include changes in cholesterol levels, liver function tests, and mood disturbances.

Serious side effects, though rare, can include severe mood changes, signs of an allergic reaction, yellowing of the skin and eyes (jaundice), a prolonged and painful erection, growth of undetected prostate cancer, or symptoms resembling a blood clot (e.g., coughing, chest pain, feeling faint, pain, swelling, redness in an affected area). If you experience any serious side effects, seek immediate medical attention.

Is Sustanon 250 mg Injection safe during pregnancy or breastfeeding?

No, Sustanon 250 mg Injection is contraindicated and must not be used by women who are pregnant, think they may be pregnant, or are breastfeeding. Its use during pregnancy carries a risk of virilization (development of male characteristics) in the fetus. There is also insufficient data to confirm its safe use during lactation.

Can Sustanon 250 mg Injection be taken with other medications?

Sustanon 250 mg Injection can interact with certain other medications. It may enhance the effects of anticoagulants (blood thinners like warfarin), requiring close monitoring and potential dose adjustments. It can also affect blood sugar levels, meaning diabetic patients using insulin or other anti-diabetic medicines may need their dosage adjusted. Concurrent use with ACTH or corticosteroids may increase the risk of fluid retention. Always inform your doctor or pharmacist about all other medicines, supplements, or herbal remedies you are taking.

What precautions should be taken with Sustanon 250 mg Injection?

Before starting treatment, inform your doctor about any existing medical conditions, especially prostate cancer or breast cancer, heart, liver, or kidney problems, diabetes, epilepsy, migraine, or sleep apnea. Regular monitoring by your doctor is essential and will include blood tests to check testosterone levels, red blood cell count, prostate-specific antigen (PSA) levels, and liver function. Sustanon 250 contains arachis (peanut) oil and benzyl alcohol, so it should not be used if you have a peanut or soya allergy. It is also not suitable for children under 3 years old due to the benzyl alcohol content.

What happens if a dose of Sustanon 250 mg Injection is missed?

If you miss a scheduled injection, you should contact your doctor or nurse as soon as possible to reschedule. It is important not to inject a double dose to compensate for the missed one. Your healthcare professional will guide you on how to proceed.

How should Sustanon 250 mg Injection be stored?

Sustanon 250 mg Injection should be stored in its original box in a safe place, out of the reach and sight of children. Keep it in a cool, dark place where the temperature stays below 30°C. Do not refrigerate or freeze the medicine, as this can make the oily solution difficult to inject. Once an ampoule is opened, the solution should be used immediately because it cannot be resealed in a way that guarantees sterility.