Dapanorm Trio Forte Tablet (10 Tab)

DAPANORM TRIO FORTE TABLET

Dapanorm Trio Forte Tablet is a prescription medication manufactured by Alkem Laboratories Ltd. designed for the comprehensive management of Type 2 Diabetes Mellitus.

• Composition: Each tablet typically contains Dapagliflozin (10mg), Metformin Hydrochloride (1000mg), and Sitagliptin (100mg) as its active ingredients. These three components work synergistically to improve glycemic control through different mechanisms.

• Uses: This medicine is prescribed to lower high blood sugar levels in adults with type 2 diabetes, used as an adjunct to diet and exercise. It helps in the proper utilization of insulin, reduces glucose production by the liver, delays glucose absorption from the intestines, and promotes the excretion of excess glucose through urine. This action helps reduce the risk of diabetes-related complications affecting the kidneys, eyes, nerves, and cardiovascular system.

• Dosage and Administration: The recommended dosage is individualized by a healthcare professional, typically taken once or twice daily. It can be taken with or without food, but taking it at a consistent time each day is advisable. Tablets should be swallowed whole and not crushed, chewed, or broken.

• Side Effects:

  • Common: Nausea, vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, headache, dizziness, hypoglycemia (low blood sugar), urinary tract infections, genital infections, and increased urination.
  • Serious (rare): Lactic acidosis, pancreatitis, severe allergic reactions, and bullous pemphigoid.

• Precautions: Patients should inform their doctor about any existing kidney, liver, or heart problems, allergies, and all current medications (including herbal supplements), as Dapanorm Trio Forte Tablet may interact with certain drugs like insulin, other antidiabetic agents, and diuretics. It is not recommended for individuals with severe kidney or liver disease, respiratory failure, heart failure, Type 1 diabetes, acute metabolic acidosis, during pregnancy, or while breastfeeding. Excessive alcohol consumption should be avoided.

• Storage: Store Dapanorm Trio Forte Tablet at room temperature, in a cool, dry place, away from direct sunlight and moisture. Keep out of the reach of children.

Dapanorm Trio Forte Tablet is a combination medication used to manage Type 2 Diabetes Mellitus. It contains three active ingredients: Dapagliflozin, Sitagliptin, and Metformin.

Here are some frequently asked questions about Dapanorm Trio Forte Tablet:

What is Dapanorm Trio Forte Tablet used for?

Dapanorm Trio Forte Tablet is used to improve blood sugar control in adults with Type 2 Diabetes Mellitus, especially when blood sugar levels are not adequately controlled by metformin alone, or by other single or dual therapies. It is used alongside a healthy diet and exercise regimen. It also helps reduce the risk of serious complications such as kidney damage, eye damage, nerve problems, loss of limbs, and may help lower the risk of heart failure and diabetic kidney disease.

How does Dapanorm Trio Forte Tablet work?

This medication combines three different agents that work together to lower blood sugar:

• Dapagliflozin: This is a sodium-glucose co-transporter 2 (SGLT2) inhibitor that removes excess sugar from the body by increasing its excretion through urine.
• Sitagliptin: This is a dipeptidyl peptidase-4 (DPP-4) inhibitor that increases the levels of certain natural substances (incretins) that lower blood sugar when it is high. It helps increase insulin release and decrease glucagon levels.
• Metformin: This is a biguanide that reduces the amount of sugar produced by the liver, delays sugar absorption from the intestines, and improves the body's sensitivity to insulin.

What is the usual dosage of Dapanorm Trio Forte Tablet?

The dosage of Dapanorm Trio Forte Tablet is individualized and determined by your doctor based on your condition, blood glucose levels, and response to treatment. It is typically taken once or twice daily, and can be taken with or without food, but consistency in timing is recommended. Do not exceed the prescribed dose or discontinue the medication without your doctor's guidance.

What are the possible side effects of Dapanorm Trio Forte Tablet?

Common side effects include urinary tract infections, genital fungal infections (especially in women), nasal congestion, sore throat, upper respiratory tract infections, diarrhea, nausea, vomiting, abdominal pain, headache, dizziness, and low blood sugar (hypoglycemia). More serious, though rare, side effects can include lactic acidosis, ketoacidosis, pancreatitis, and allergic reactions. If any side effects persist or worsen, or if you experience serious symptoms, consult your doctor immediately.

Is Dapanorm Trio Forte Tablet safe during pregnancy or breastfeeding?

There is limited information on the effect of Dapanorm Trio Forte Tablet in pregnant women, and it is generally not recommended during pregnancy. It is also generally not recommended during breastfeeding as some components may pass into breast milk. Always inform your doctor if you are pregnant, planning pregnancy, or breastfeeding before taking this medication.

Can Dapanorm Trio Forte Tablet be taken with other medications?

It is crucial to inform your doctor about all other medicines, herbal remedies, and supplements you are taking to avoid possible interactions. Caution should be exercised with medicines for heart failure (e.g., digoxin), diuretics (e.g., furosemide, hydrochlorothiazide), and other anti-diabetic medications like insulin or sulfonylureas, as these can increase the risk of low blood sugar or other complications. Cationic medicines such as amiloride, cimetidine, and quinidine can also increase the accumulation of metformin, raising the risk of lactic acidosis.

What precautions should be taken?

Inform your doctor about any existing medical conditions, especially kidney or liver problems, heart conditions, or urinary tract infections, as Dapanorm Trio Forte Tablet may not be suitable or may require dose adjustments. Avoid excessive alcohol consumption as it can increase the risk of hypoglycemia and lactic acidosis. Regular monitoring of blood sugar levels and kidney function is essential while on this medication.

What happens if a dose is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should Dapanorm Trio Forte Tablet be stored?

Store Dapanorm Trio Forte Tablet in a cool and dry place, below 30°C and away from direct sunlight. Keep it out of the sight and reach of children and pets.