Alsita 50 Mg Tablet (10 Tab)

ALSITA 50 MG TABLET

ALSITA 50 MG TABLET is an oral antidiabetic medication manufactured by Alkem Laboratories Ltd., primarily used for the management of type 2 diabetes mellitus in adults.

Composition The active ingredient in ALSITA 50 MG TABLET is Sitagliptin (50 mg). It belongs to a class of drugs known as dipeptidyl peptidase-4 (DPP-4) inhibitors. Sitagliptin works by increasing the levels of incretin hormones in the body, which helps stimulate insulin release when blood glucose is high and reduces glucose production by the liver, thereby controlling blood sugar levels.

Uses ALSITA 50 MG TABLET is prescribed to:

• Manage high blood sugar levels in adults with type 2 diabetes mellitus.
• Be used as an adjunct to diet and exercise to improve glycemic control when diet, exercise, and single medicinal therapy are insufficient.
• Assist in preventing serious complications associated with diabetes, such as kidney damage, blindness, nerve problems, limb amputations, and sexual dysfunction.
• Help reduce the risk of heart attack and stroke in diabetic patients.

Dosage and Administration ALSITA 50 MG TABLET is typically taken once daily, with or without food, as advised by a doctor. The tablet should be swallowed whole with a glass of water and not crushed or chewed. For patients with kidney problems, the dosage may need to be adjusted. Consistent timing of medication intake is important. If a dose is missed, it should be taken as soon as remembered, unless it's almost time for the next dose.

Side Effects Common side effects include:

• Headache
• Upper respiratory tract infection, nasopharyngitis (inflammation of the nasal passages and throat)
• Hypoglycemia (low blood sugar), especially when used with other antidiabetic medicines or insulin.
• Joint pain
• Stomach pain, nausea, vomiting, diarrhea, constipation, and flatulence.

Serious side effects, though rare, can include:

• Pancreatitis (inflammation of the pancreas), characterized by severe and persistent stomach pain that may spread to the back.
• Severe allergic reactions (rash, hives, blistering, swelling of the face, lips, tongue, and throat).
• Heart failure.

Precautions Before taking ALSITA 50 MG TABLET, inform your doctor if you have kidney disease, heart problems, pancreas problems, a history of pancreatitis, gallstones, or high triglyceride levels. It is not recommended for individuals with type 1 diabetes or diabetic ketoacidosis. Pregnant or breastfeeding women should consult their doctor before using this medicine. Alcohol consumption should be avoided as it can alter blood glucose levels and increase the risk of hypoglycemia. Regular monitoring of kidney function and blood glucose levels is advised.

Storage Store ALSITA 50 MG TABLET below 30°C in a cool and dry place, away from sunlight and moisture. Keep it out of sight and reach of children and pets.

What is ALSITA 50 MG TABLET used for?

ALSITA 50 MG TABLET is primarily used to manage high blood sugar levels in adults with type 2 diabetes mellitus. It is typically prescribed as an addition to a healthy diet and regular exercise. By helping to control blood sugar, it aids in preventing serious complications associated with diabetes, such as kidney damage, blindness, nerve problems, limb amputations, sexual dysfunction, and can also reduce the risk of heart attack and stroke.

How does ALSITA 50 MG TABLET work?

ALSITA 50 MG TABLET contains Sitagliptin, which belongs to a class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by increasing the levels of certain natural substances in the body called incretin hormones (GLP-1 and GIP). These hormones help the pancreas release more insulin when blood sugar levels are high and also signal the liver to reduce its production of sugar. This process ultimately helps the body utilize insulin more effectively and lowers blood glucose levels.

What is the usual dosage for ALSITA 50 MG TABLET?

The usual recommended dosage of Sitagliptin (the active ingredient in ALSITA 50 MG TABLET) for adults is 100 mg once daily. However, for individuals with kidney problems, your doctor may prescribe a lower dose, such as 25 mg or 50 mg once a day. ALSITA 50 MG TABLET should be taken once daily, at approximately the same time each day, with or without food. The tablet should be swallowed whole and not crushed or chewed.

What are the possible side effects of ALSITA 50 MG TABLET?

Common side effects can include headaches, a stuffed or runny nose, sore throat, diarrhea, and nausea.

More serious side effects are rare but require immediate medical attention. These include severe stomach pain (which may spread to your back and could indicate pancreatitis), severe and disabling joint pain, and serious allergic reactions (such as rash, itching, hives, swelling of the face, lips, tongue, or throat, or difficulty breathing). Other serious but rare side effects to report immediately are blistering or peeling skin (which can be signs of conditions like Stevens-Johnson syndrome or bullous pemphigoid), and symptoms of heart failure (such as shortness of breath, swelling in the ankles, feet, or hands, sudden weight gain, or unusual fatigue) or kidney injury.

Is ALSITA 50 MG TABLET safe during pregnancy or breastfeeding?

ALSITA 50 MG TABLET (Sitagliptin) is generally not recommended during pregnancy due to limited information regarding its potential effects on a developing baby. If you are pregnant or planning to become pregnant, you should discuss your treatment with your doctor, who may suggest a safer alternative.

During breastfeeding, Sitagliptin is also generally not recommended. It is unknown how much of the medicine passes into breast milk, although it is likely a small amount. If you are breastfeeding, especially a newborn or premature baby, consult your doctor to review your treatment. Monitoring the breastfed infant's blood glucose may be advisable if the mother continues to use Sitagliptin.

Can ALSITA 50 MG TABLET be taken with other medications?

Yes, ALSITA 50 MG TABLET can be used alone or in combination with other diabetes medications, such as insulin, glimepiride, metformin, or pioglitazone, as directed by your doctor.

However, caution is advised when taking it with certain medications. If taken with insulin or insulin secretagogues (like sulfonylureas), your doctor may need to adjust the dosage of these medications to reduce the risk of low blood sugar (hypoglycemia). There is also an increased risk of angioedema when used with ACE inhibitors. Digoxin levels may need monitoring if taken concurrently, as Sitagliptin can increase its plasma concentrations. Medications like corticosteroids and diuretics can also affect blood glucose control. Always inform your doctor or pharmacist about all prescription and non-prescription drugs, vitamins, supplements, and herbal products you are currently taking.

What precautions should be taken while taking ALSITA 50 MG TABLET?

Before taking ALSITA 50 MG TABLET, inform your doctor if you have a history of pancreatitis, kidney disease, heart failure, or have experienced severe allergic reactions to Sitagliptin or similar medications. This medication is not suitable for individuals with type 1 diabetes or diabetic ketoacidosis.

It is crucial to follow the special meal plan and exercise regimen recommended by your doctor. Regularly monitor your blood sugar levels as instructed. It's also advisable to wear a medical identification bracelet or carry a card indicating you have diabetes and listing your medications. Be aware that factors like illness, stress, travel, or alcohol consumption can affect your blood sugar levels. Inform your healthcare providers, including dentists, if you are taking Sitagliptin before any surgery.

What happens if a dose of ALSITA 50 MG TABLET is missed?

If you miss a dose of ALSITA 50 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the forgotten one.

How should ALSITA 50 MG TABLET be stored?

ALSITA 50 MG TABLET should be stored in a closed container at room temperature, typically between 68°F to 77°F (20°C to 25°C), away from excessive heat, moisture, and direct light. It should be kept from freezing. Always keep this medicine out of the reach of children.