METROGYL O TABLET

METROGYL O TABLET is a potent combination medication manufactured by J B Chemicals and Pharmaceuticals Ltd., primarily used to treat a variety of bacterial and parasitic infections.

• Name:

  • Brand Name: METROGYL O TABLET
  • Common Name: Ofloxacin and Metronidazole Tablets

• Composition: Each tablet contains two active ingredients:

  • Ofloxacin (200 mg)
  • Metronidazole (500 mg) Ofloxacin is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, stopping bacterial growth, while Metronidazole is a nitroimidazole antibiotic that disrupts the DNA of susceptible microorganisms, leading to their death.

• Uses: This medication provides broad-spectrum efficacy against mixed infections where both anaerobic bacteria and protozoa are present. It is prescribed for:

  • Abdominal, dental, lung, skin, urinary tract, genital, brain, and blood infections
  • Diarrhea and dysentery, including amoebic dysentery and those caused by mixed infections
  • Gynecological infections, such as bacterial vaginosis and pelvic inflammatory disease (PID)
  • Prevention of post-operative infections
  • Protozoal infections like giardiasis and amoebiasis

• Dosage and Administration: Take METROGYL O TABLET exactly as prescribed by your doctor. It should be swallowed whole with water, preferably after food to minimize stomach upset. Generally, for adults, the typical dosage might range from one tablet two to three times daily. It is crucial to complete the entire course of treatment, even if symptoms improve, to prevent recurrence and antibiotic resistance.

• Side Effects: Common side effects may include:

  • Nausea, vomiting, stomach pain, loss of appetite
  • Dry mouth, metallic taste, headache, dizziness More serious, though less common, side effects can include peripheral neuropathy, seizures, and allergic reactions. Consult your doctor if any side effects persist or worsen.

• Precautions:

  • Alcohol: Avoid alcohol consumption during treatment and for at least 48 hours after the last dose, as it can cause unpleasant side effects such as nausea, vomiting, headache, and flushing (disulfiram-like reaction).
  • Pregnancy and Breastfeeding: METROGYL O TABLET should generally be avoided during pregnancy (especially the first trimester) and breastfeeding. Consult your doctor for risks and benefits.
  • Medical Conditions: Inform your doctor about any pre-existing conditions, especially liver or kidney disease, epilepsy, blood dyscrasias, or neurological disorders.
  • Drug Interactions: Inform your doctor about all other medications, including over-the-counter drugs, herbal supplements, and vitamins, as interactions can occur.
  • Driving: This medication may cause dizziness, confusion, or drowsiness; avoid driving or operating machinery until you know how it affects you.

• Storage: Store METROGYL O TABLET in a cool, dry place, away from direct sunlight and moisture, and out of reach of children and pets. Ideal storage temperature is below 30°C.

Frequently Asked Questions about Metrogyl O Tablet

What is Metrogyl O Tablet used for?

Metrogyl O Tablet is a combination medication containing Ofloxacin and Metronidazole, used to treat various bacterial and parasitic infections. It is effective for conditions such as bacterial diarrhea, amoebic dysentery, and other infections affecting the lungs, skin, prostate, urinary tract, gastrointestinal tract, and genital tract. It can also be prescribed for dental infections, gynecological infections like bacterial vaginosis and pelvic inflammatory disease, and to prevent infections after surgery.

How does Metrogyl O Tablet work?

Metrogyl O Tablet contains two active ingredients: Ofloxacin and Metronidazole. Ofloxacin is an antibacterial that prevents bacterial cells from dividing and inhibits their repair mechanisms, leading to the death of the bacteria. Metronidazole is effective against parasites and anaerobic bacteria by damaging their DNA, which results in their elimination. Together, these antibiotics work synergistically to treat a broad range of infections.

What is the usual dosage for Metrogyl O Tablet?

Metrogyl O Tablet should be taken exactly as prescribed by your doctor. The dosage and duration of treatment depend on the type and severity of your infection, as well as your medical condition. It is typically taken orally with a full glass of water, and can be taken with or without food, though taking it with food may help reduce stomach upset. It's crucial to complete the entire course of treatment, even if you start feeling better, to ensure the infection is fully cleared and to prevent antibiotic resistance. Do not crush, chew, or break the tablet.

What are the possible side effects of Metrogyl O Tablet?

Common side effects of Metrogyl O Tablet may include nausea, vomiting, stomach upset, loss of appetite, dry mouth, a metallic taste in the mouth, headache, dizziness, drowsiness, and confusion. Most of these side effects are usually mild and temporary, resolving on their own. However, if any side effects are persistent, severe, or worsen, you should contact your doctor. More serious, but rare, side effects can include peripheral neuropathy (numbness, tingling in hands and feet), seizures, and allergic reactions.

Is Metrogyl O Tablet safe during pregnancy or breastfeeding?

Metrogyl O Tablet should not be taken during pregnancy, especially in the first trimester, as it may cause harm to the fetus. If you become pregnant while taking this medication, stop taking it and contact your doctor immediately. It is also not recommended during breastfeeding as it may pass into breast milk and harm the nursing infant. Always consult your doctor for advice on safer alternatives if you are pregnant or breastfeeding.

Can Metrogyl O Tablet be taken with other medications?

It is important to inform your doctor about all medications, supplements, and herbal products you are currently taking, as they may interact with Metrogyl O Tablet. For example, combining it with disulfiram can lead to psychotic symptoms. Certain antacids, blood thinners (like warfarin), antidiabetic drugs, and some antiepileptic medications can also interact with Metrogyl O Tablet, affecting its effectiveness or increasing the risk of side effects.

What precautions should be taken with Metrogyl O Tablet?

Avoid alcohol consumption during treatment with Metrogyl O Tablet and for at least 48-72 hours after the last dose, as it can cause unpleasant side effects such as nausea, vomiting, headaches, flushing, and a fast heartbeat (known as a disulfiram-like reaction). Metrogyl O Tablet can cause dizziness, confusion, and drowsiness, so avoid driving or operating machinery until you know how it affects you. Use with caution if you have a history of liver disease, kidney disease, low white blood cell count (leukopenia), seizures, gastrointestinal diseases (like Crohn's disease), or other neurological disorders. Avoid dairy products and minimize exposure to strong sunlight and UV light while on this medication.

What happens if a dose is missed?

If you miss a dose of Metrogyl O Tablet, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should Metrogyl O Tablet be stored?

Metrogyl O Tablet should be stored in a cool and dry place, away from direct sunlight and moisture. Keep it in its original container, tightly closed, and out of sight and reach of children and pets. The recommended storage temperature is typically between 10ºC to 25ºC or below 30ºC.