Penegra 25 Tablet

PENEGRA 25 TABLET is a medication manufactured by Zydus Healthcare Limited (also referred to as Zydus Cadila or Zydus Lifesciences Limited) primarily used for the treatment of erectile dysfunction.

Name

• Brand Name: Penegra 25 Tablet
• Common Name: Sildenafil

Composition

PENEGRA 25 TABLET contains Sildenafil (25mg) as its active ingredient. Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor.

Uses

PENEGRA 25 TABLET is prescribed for the following medical conditions:

• Erectile Dysfunction (ED): It is used to treat impotence in men by increasing blood flow to the penis, helping men achieve and maintain an erection when sexually stimulated.
• Pulmonary Arterial Hypertension (PAH): It may also be used to treat high blood pressure in the lungs, relaxing blood vessels, increasing lung circulation, and reducing the heart's workload to improve exercise capacity and slow clinical worsening.

Dosage and Administration

• For erectile dysfunction, the typical starting adult dose is often 50 mg, taken approximately one hour before sexual activity, but it can be adjusted to 25 mg or increased to a maximum of 100 mg based on individual response and tolerability.
• PENEGRA 25 TABLET should be taken orally with a glass of water, typically 30 to 60 minutes before anticipated sexual activity.
• It can be taken with or without food, but taking it with heavy or high-fat meals may delay its onset of action.
• Do not take more than one dose in 24 hours. Sexual arousal is required for the tablet to work effectively.

Side Effects

Common Side Effects:

• Headache
• Flushing (sense of warmth in the face, ears, neck, and trunk)
• Nosebleeds
• Blurred vision or visual disturbances
• Indigestion or upset stomach
• Muscle pain or aches
• Dizziness
• Nasal congestion

Serious Side Effects:

• Priapism (a painful erection lasting more than 4 hours)
• Severe allergic reactions (e.g., wheeziness, difficulty breathing, swelling of face, lips, eyelids, or throat)
• Sudden decrease or loss of vision
• Sudden decrease or loss of hearing
• Chest pain or irregular heartbeat
• Severe low blood pressure
• Seizures

Precautions

• Contraindications: Do not take PENEGRA 25 TABLET if you are allergic to Sildenafil or any other ingredients. It is contraindicated if you are taking nitrates (often prescribed for chest pain or angina) or riociguat (for pulmonary hypertension), as this combination can cause a severe and potentially fatal drop in blood pressure.
• Medical Conditions: Inform your doctor if you have heart problems (e.g., recent heart attack or stroke), blood circulation problems, severe liver or kidney disease, low blood pressure, eye conditions (e.g., retinitis pigmentosa, vision loss due to non-arteritic anterior ischaemic optic neuropathy), bleeding disorders, stomach ulcers, sickle cell anemia, or cancers of the blood/bone marrow (leukemia, multiple myeloma).
• Alcohol: Avoid or limit alcohol consumption as it can worsen side effects like dizziness and lower blood pressure.
• Driving and Machinery: PENEGRA 25 TABLET may cause dizziness or blurred vision, so avoid driving or operating machinery until you know how it affects you.
• Not for Women or Children: This medicine is not intended for use in women or children under 18 years of age.
• Dosage: Never take more than the prescribed dose, as it can increase the severity of side effects.

Storage

Store PENEGRA 25 TABLET in a cool and dry place, away from direct sunlight and moisture. Keep it out of sight and reach of children and pets. Do not store in humid areas like bathrooms.

Penegra 25 Tablet, manufactured by Zydus Healthcare Limited, contains Sildenafil as its active ingredient. It is primarily used to treat erectile dysfunction in men, and in some cases, pulmonary arterial hypertension.

What is Penegra 25 Tablet used for?

Penegra 25 Tablet is primarily used to treat erectile dysfunction (impotence) in adult men, helping them achieve and maintain an erection sufficient for sexual activity. It may also be used to treat pulmonary arterial hypertension (high blood pressure in the lungs) to improve exercise capacity and slow clinical worsening.

How does Penegra 25 Tablet work?

Penegra 25 Tablet contains Sildenafil, which belongs to a class of medicines called Phosphodiesterase type 5 (PDE5) inhibitors. It works by relaxing the blood vessels in the penis, allowing increased blood flow to the area when a man is sexually stimulated, thus facilitating an erection. For pulmonary arterial hypertension, it relaxes blood vessels, increasing blood supply to the lungs and reducing the heart's workload.

What is the usual dosage for Penegra 25 Tablet?

For erectile dysfunction, Penegra 25 Tablet is typically taken as a single dose approximately 30 to 60 minutes before anticipated sexual activity, though it can be taken up to 4 hours prior. It should not be taken more than once a day. The exact dosage and frequency will be determined by your doctor based on your condition and response.

What are the possible side effects of Penegra 25 Tablet?

Common side effects may include flushing (sense of warmth), headache, dizziness, blurred vision, muscle pain, indigestion, nausea, and a stuffy nose. More serious side effects, though rare, require immediate medical attention. These include a severe allergic reaction (such as difficulty breathing or swelling of the face/lips), priapism (an erection lasting more than 4 hours), chest pain, sudden vision loss, or sudden hearing loss.

Is Penegra 25 Tablet safe during pregnancy or breastfeeding?

Penegra 25 Tablet is not suitable for use in women and is contraindicated during pregnancy and breastfeeding, particularly when used for erectile dysfunction. If it is prescribed for pulmonary arterial hypertension in women, a doctor will weigh the benefits against the risks.

Can Penegra 25 Tablet be taken with other medications?

It is crucial to avoid taking Penegra 25 Tablet with nitrates (medicines for chest pain like nitroglycerin or isosorbide dinitrate) as their combined use can cause a dangerous and potentially fatal drop in blood pressure. It should also not be taken with Riociguat. Inform your doctor about all other medications you are taking, especially alpha-blockers (for prostate problems or blood pressure), protease inhibitors, and other blood pressure-lowering medicines, as interactions can occur.

What precautions should be taken while using Penegra 25 Tablet?

Avoid consuming alcohol with Penegra 25 Tablet as it can worsen side effects such as dizziness. Taking it with heavy meals may delay its onset of action. Do not drive or operate machinery if you experience dizziness or blurred vision after taking this medicine. Inform your doctor about any pre-existing conditions, including heart, kidney, or liver problems, rare inherited eye diseases, blood disorders (like sickle cell anemia, leukemia), or penile deformities. Penegra 25 Tablet is not recommended for individuals under 18 years of age.

What happens if a dose of Penegra 25 Tablet is missed?

Since Penegra 25 Tablet for erectile dysfunction is taken on an as-needed basis, the concept of a "missed dose" typically does not apply. You should take it approximately 30 minutes to 4 hours before sexual activity. If you are prescribed Penegra for pulmonary arterial hypertension and miss a regular dose, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed one and do not take a double dose to compensate.

How should Penegra 25 Tablet be stored?

Penegra 25 Tablet should be stored in a cool, dry place, away from direct sunlight and moisture. Keep it out of sight and reach of children and pets, typically at room temperature (between 10ºC and 30ºC).