Lizoforce Dry Syrup

LIZOFORCE DRY SYRUP

LIZOFORCE DRY SYRUP is an antibiotic medication manufactured by Mankind Pharmaceuticals Ltd.. It is primarily used to treat various serious bacterial infections.

• Name:

  • Brand Name: Lizoforce Dry Syrup
  • Common Name: Linezolid Dry Syrup

• Composition: LIZOFORCE DRY SYRUP contains Linezolid 100 mg/5ml as its active ingredient. Linezolid belongs to the oxazolidinone class of antibiotics.

• Uses: LIZOFORCE DRY SYRUP is used to manage a variety of bacterial infections caused by susceptible gram-positive bacteria in children. It works by inhibiting the formation of the bacterial cell wall, which leads to the death of the bacterial cell and prevents the growth of infections. It is prescribed for:

  • Nosocomial pneumonia (lung infection acquired in a hospital setting)
  • Community-acquired pneumonia (lung infection caught outside healthcare settings)
  • Complicated and uncomplicated skin and skin structure infections
  • Vancomycin-resistant Enterococcus faecium infections
  • Resistant Tuberculosis (TB)
  • Severe bacterial infections affecting the skin, soft tissues, bones, brain, heart, urinary tract, lungs, and blood.
  • It is not effective against viral infections like the common cold or flu.

• Dosage and Administration: The medication is given orally. It should be reconstituted by adding the prescribed amount of water and shaken well until the powder dissolves completely. It can be administered with or without food, but giving it with food may help mitigate nausea. Use a dosing spoon or oral syringe to measure the exact dose. The dosage is determined by a doctor based on the severity of the infection, and the child's age and weight. It is important to complete the full course of treatment as prescribed, even if symptoms improve, to ensure complete eradication of bacteria and prevent resistance.

• Side Effects: Common side effects may include:

  • Diarrhoea
  • Headache
  • Nausea
  • Vomiting
  • Dizziness
  • Altered taste (e.g., metallic taste)
  • Rash
  • Indigestion
  • Stomach pain
  • Decreased blood pressure
  • Decreased blood cells (red cells, white cells, and platelets)
  • Constipation
  • Fever

  Serious side effects, though rare, can include low blood cell count, vision problems, nerve damage, or lactic acidosis (symptoms like abdominal pain, nausea, vomiting, generalized weakness). If severe or persistent side effects occur, medical attention should be sought.

• Precautions:

  • Allergies: Avoid use if there is a known hypersensitivity to linezolid or any syrup excipients.
  • Liver and Kidney Issues: Caution is advised for children with liver or kidney problems.
  • Drug-Food Interactions: Avoid consuming tyramine-rich foods (e.g., aged cheese, smoked meats) in moderation to prevent a sudden spike in blood pressure.
  • Other Medications: Inform the doctor about all other medications, including over-the-counter drugs and supplements, to avoid potential interactions.
  • Diabetes: As it is sugar-based, diabetic patients should consult a doctor.
  • Pregnancy and Breastfeeding: Use with caution during pregnancy and breastfeeding; consult a doctor.

• Storage: Store LIZOFORCE DRY SYRUP in its original packaging at a temperature not exceeding 30°C, in a cool and dry place, away from direct sunlight. After reconstitution, store the syrup at room temperature and use it within 21 days. Keep this medicine out of reach of children.

1. What is Lizoforce Dry Syrup used for?

Lizoforce Dry Syrup is an antibiotic medication primarily used to treat a wide range of serious bacterial infections, especially those caused by drug-resistant gram-positive bacteria. It is commonly prescribed for infections such as pneumonia (including community-acquired and nosocomial types), skin and soft tissue infections, and certain severe infections like those caused by vancomycin-resistant Enterococcus faecium (VRE) and resistant tubercular infections. This medicine is intended for bacterial infections and will not work for viral infections like the common cold or flu.

2. How does Lizoforce Dry Syrup work?

Lizoforce Dry Syrup contains Linezolid, an antibiotic belonging to the oxazolidinone class. It works by inhibiting the growth and replication of bacteria. It achieves this by stopping the production of proteins that are essential for the bacteria to multiply and survive.

3. What is the usual dosage of Lizoforce Dry Syrup?

The dosage of Lizoforce Dry Syrup is determined by a doctor based on the patient's age, weight, and the type and severity of the infection. Lizoforce Dry Syrup is often intended for pediatric use. It should be administered orally, usually at a consistent time each day, with or without food. If stomach upset occurs, taking it with food may help. The dry syrup needs to be reconstituted by adding the prescribed amount of water and shaking well before use. The dose should be measured accurately using a measuring device.

For children, a common dosage for the active ingredient Linezolid can be 10 mg/kg every 8 or 12 hours, typically for 10-14 days, depending on the age group. For instance, children under 5 years might receive 10 mg/kg every 8 hours, while those between 5-12 years might receive 10 mg/kg every 12 hours. Children 12 years and older may be prescribed 600 mg every 12 hours.

4. What are the possible side effects of Lizoforce Dry Syrup?

Common side effects may include diarrhea, nausea, vomiting, headache, dizziness, altered taste (metallic taste), indigestion, and stomach pain. Skin rash and oral thrush can also occur.

More serious, but less common, side effects can include a decrease in blood cell counts (red blood cells, white blood cells, and platelets), irregular heartbeat, convulsions, or a serious condition called lactic acidosis. If any severe or persistent side effects occur, especially symptoms like severe diarrhea, vision problems, unusual bleeding or bruising, or difficulty breathing, immediate medical attention is required.

5. Is Lizoforce Dry Syrup safe during pregnancy or breastfeeding?

Lizoforce Dry Syrup should be used with caution during pregnancy, and it is advisable to consult a doctor before use, as safety has not been fully established. Some sources recommend avoiding its use during pregnancy.

For breastfeeding mothers, Lizoforce Dry Syrup passes into breastmilk. It is generally recommended to avoid breastfeeding while taking this medication, or to consult a doctor to weigh the potential benefits against the risks.

6. Can Lizoforce Dry Syrup be taken with other medications?

Lizoforce Dry Syrup can interact with several other medications. It is crucial to inform your doctor about all prescription, over-the-counter, herbal, and dietary supplements you are currently taking. Notable interactions include:

• Monoamine Oxidase (MAO) Inhibitors and Antidepressants: Co-administration with MAO inhibitors or certain antidepressants (like SSRIs or tricyclic antidepressants) should be avoided due to a significant risk of serotonin syndrome, which can be life-threatening.
• Antidiabetic medications: Linezolid may increase the effects of some antidiabetic medications (e.g., glimepiride, glipizide, metformin), leading to a higher risk of low blood glucose.
• Other Medications: Interactions with drugs like ondansetron have also been noted.

Close monitoring may be required if certain medications cannot be avoided.

7. What precautions should be taken while using Lizoforce Dry Syrup?

• Complete the full course: It is essential to complete the entire prescribed course of Lizoforce Dry Syrup, even if symptoms improve, to ensure the infection is fully eradicated and to prevent antibiotic resistance.
• Dietary Restrictions: Avoid consuming large amounts of tyramine-rich foods (e.g., aged cheeses, smoked or fermented meats/fish, red wine, soy products, certain beers, pickles, overripe fruits) while taking this medicine. This can lead to a significant increase in blood pressure.
• Alcohol: Avoid alcohol consumption during treatment.
• Medical Conditions: Use with caution and inform your doctor if you have a history of severe liver or kidney problems, uncontrolled high blood pressure, bone marrow problems, heart problems, seizures, diabetes, or colitis.
• Drowsiness/Dizziness: This medication may cause dizziness or drowsiness. Avoid driving or operating heavy machinery if you experience these symptoms.
• Not for Viral Infections: Remember that Lizoforce Dry Syrup is an antibiotic and is not effective against viral infections.

8. What should I do if a dose of Lizoforce Dry Syrup is missed?

If a dose of Lizoforce Dry Syrup is missed, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up. If vomiting occurs within 30 minutes of taking a dose, you may give the same dose again, but do not give a double dose if the next one is due soon.

9. How should Lizoforce Dry Syrup be stored?

Lizoforce Dry Syrup should be stored in its original container at room temperature, generally below 30°C, away from excess heat and moisture. After reconstitution (mixing with water), the solution has a limited shelf life (e.g., often 21 days for Linezolid oral suspensions) and should be used within that period. Always keep the medicine out of the sight and reach of children and pets.