Nervite Plus Tab

Nervite Plus Tablet is a combination medication manufactured by Macleods Pharmaceuticals Pvt Ltd, primarily prescribed for the management of neuropathic pain.

Composition

Nervite Plus Tablet contains three active ingredients:

• Pregabalin: Typically 75 mg, an anticonvulsant that reduces pain by modulating calcium channel activity in nerve cells.
• Nortriptyline: Typically 10 mg, a tricyclic antidepressant that increases levels of serotonin and noradrenaline, chemical messengers that inhibit pain signals in the brain.
• Methylcobalamin (Mecobalamin): Typically 1500 mcg, a form of Vitamin B12 that aids in the production of myelin, protecting nerve fibers and regenerating damaged nerve cells.

Uses

This medication is used to treat various conditions involving nerve damage and chronic pain, including:

• Neuropathic pain, such as diabetic peripheral neuropathy and postherpetic neuralgia (shingles).
• Fibromyalgia.
• Epilepsy and seizures.
• Spinal cord injury.
• Generalized anxiety disorder.
• Chronic pain and depression.

Dosage and Administration

Nervite Plus Tablet is taken orally, with or without food, as directed by a healthcare professional. The initial dose for neuropathic pain may be around 50 mg, taken three times a day, with adjustments based on efficacy and tolerability. It is crucial not to suddenly stop taking the medicine, as it may worsen symptoms or cause withdrawal effects.

Side Effects

Common side effects include:

• Dizziness, sleepiness, and tiredness.
• Dry mouth.
• Weight gain.
• Blurred or double vision.
• Constipation.
• Increased heart rate.

More serious but rare side effects can include angioedema, difficulty in breathing, changes in mood or behavior (e.g., increased risk of suicide), and uncoordinated body movements.

Precautions

• Alcohol: Avoid alcohol consumption as it may increase side effects like dizziness and drowsiness.
• Pregnancy and Breastfeeding: Generally not recommended during pregnancy or breastfeeding unless absolutely necessary, due to potential risks to the fetus or infant.
• Driving and Machinery: Avoid driving or operating heavy machinery if experiencing dizziness, sleepiness, or blurred vision.
• Medical Conditions: Inform your doctor if you have liver or kidney problems, diabetes, heart problems, or a history of angioedema or seizures.
• Drug Interactions: Exercise caution with other medications, particularly antidepressants, anti-anxiety medications (e.g., benzodiazepines), and antiepileptic drugs.
• Elderly Patients: Use with caution in elderly patients, as they may be more susceptible to side effects.
• Dependence: Prolonged use may lead to addiction, and should only be used as prescribed.

Storage

Store Nervite Plus Tablet in a cool, dry place, in its original packaging, and out of sight and reach of children and pets.

NERVITE PLUS TAB by MACLEODS PHARMACEUTICALS PVT LTD is a combination medication primarily used for managing neuropathic pain. It contains Pregabalin, Nortriptyline, and Methylcobalamin, which work together to alleviate nerve-related discomfort.

What is Nervite Plus Tablet used for?

Nervite Plus Tablet is primarily used to treat neuropathic pain, which is pain caused by nerve damage. This includes conditions such as diabetic peripheral neuropathy, postherpetic neuralgia (shingles pain), spinal cord injury, and fibromyalgia. It may also be prescribed for epilepsy, restless leg syndrome, generalized anxiety disorder, chronic pain, and to help manage depression and anxiety associated with nerve pain.

How does Nervite Plus Tablet work?

Nervite Plus Tablet combines three active ingredients:

• Pregabalin works by modulating calcium channel activity in nerve cells within the central nervous system, reducing the release of neurotransmitters involved in transmitting pain signals.
• Nortriptyline is a tricyclic antidepressant that increases the levels of chemical messengers like serotonin and noradrenaline in the brain, which helps to stop the movement of pain signals.
• Methylcobalamin (a form of Vitamin B12) promotes nerve regeneration and helps in the production of myelin, a substance that protects nerve fibers and rejuvenates damaged nerve cells. These components act synergistically to target different mechanisms of neuropathic pain, providing comprehensive relief.

What is the usual dosage for Nervite Plus Tablet?

The dosage of Nervite Plus Tablet is determined by your doctor, based on your medical condition and response to treatment. It is typically taken orally, with or without food, at a fixed time each day to maintain consistent medicine levels. The tablet should be swallowed whole and not chewed or crushed. An initial dose might be around 50 mg, three times a day, which can be adjusted as needed by your doctor.

What are the possible side effects of Nervite Plus Tablet?

Common side effects may include dry mouth, dizziness, sleepiness, blurred vision, weight gain, constipation, orthostatic hypotension (sudden drop in blood pressure upon standing), increased heart rate, and tiredness. Less common but more serious side effects can include difficulty breathing, chest tightness, confusion, trouble with memory, poor motor coordination, angioedema (swelling under the skin), and an increased risk of suicidal thoughts. If you experience severe or persistent side effects, or any unusual changes in mood or behavior, consult your doctor immediately.

Is Nervite Plus Tablet safe during pregnancy or breastfeeding?

Nervite Plus Tablet is generally not recommended during pregnancy unless explicitly advised by a doctor, who will weigh the potential benefits against the risks. Limited human data exist, and animal studies have shown potential harmful effects on the developing baby. Similarly, it is usually not recommended for breastfeeding women, as its ingredients may pass into breast milk and could harm the infant. If use is deemed necessary during breastfeeding, discontinuation of breastfeeding may be advised. Always consult your doctor before using this medicine if you are pregnant, planning to become pregnant, or breastfeeding.

Can Nervite Plus Tablet be taken with other medications?

Nervite Plus Tablet can interact with various medications. It is crucial to inform your doctor about all medicines, supplements, and herbal products you are currently taking. Potential interactions can occur with alcohol (which should be avoided due to increased drowsiness and dizziness), other antidepressants (e.g., MAO inhibitors, fluoxetine, sertraline), anti-anxiety medications (e.g., benzodiazepines like lorazepam), antiepileptic drugs, opioid pain relievers (e.g., oxycodone, tramadol), and medicines for diabetes, psychiatric illnesses, blood pressure, or heart problems.

What precautions should be taken while using Nervite Plus Tablet?

Before taking Nervite Plus Tablet, inform your doctor if you have liver or kidney problems, diabetes, a history of seizures, or angioedema. This medicine can cause dizziness and sleepiness, so avoid driving or operating heavy machinery until you understand how it affects you. Do not stop taking the medication abruptly, as it can lead to withdrawal symptoms; the dose should be gradually reduced under medical supervision. Monitor for any unusual changes in mood or behavior, including new or worsening depression or suicidal thoughts, and seek immediate medical help if these occur. Managing weight gain with a balanced diet and regular exercise is also advised.

What happens if a dose of Nervite Plus Tablet is missed?

If you miss a dose of Nervite Plus Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one, as this can increase the risk of side effects.

How should Nervite Plus Tablet be stored?

Nervite Plus Tablet should be stored in a cool, dry place, typically at room temperature. Keep it in its original packaging or container, out of the sight and reach of children and pets. It should also be protected from light and moisture.