Zenoxa 600 Tablet

ZENOXA 600 TABLET

ZENOXA 600 TABLET, manufactured by Intas Pharmaceuticals Ltd., is an anti-epileptic medication primarily used to manage and prevent seizures.

• Name:

  • Brand Name: Zenoxa 600 Tablet
  • Common Name: Oxcarbazepine

• Composition:

  • Each tablet contains Oxcarbazepine 600 mg as the active ingredient.

• Uses: ZENOXA 600 TABLET is prescribed for the treatment and prevention of epilepsy and seizures. It is particularly effective in controlling partial seizures, with or without secondarily generalized tonic-clonic seizures, in adults and children aged 6 years and above. It works by decreasing abnormal and excessive nerve impulses in the brain that cause seizures.

• Dosage and Administration: ZENOXA 600 TABLET should be taken exactly as directed by a doctor, typically twice daily. It can be taken with or without food. To achieve maximum benefit and help with adherence, it should be taken at the same time each day. The tablet should be swallowed whole with water and not crushed, broken, or chewed. Do not stop taking this medicine suddenly, as it may increase seizure frequency; the dose should be reduced gradually under medical supervision.

• Side Effects: Common side effects may include headache, nausea, vomiting, dizziness, drowsiness, fatigue, abnormal gait, visual disturbances (like blurred or double vision), involuntary eye movement (nystagmus), tremors, vertigo, and a decrease in blood sodium levels. Serious side effects can include severe skin rashes (e.g., Stevens-Johnson syndrome), signs of low white blood cell count, and suicidal thoughts or behavior.

• Precautions:

  • Avoid consuming alcohol, as it may increase drowsiness and dizziness.
  • May cause dizziness and sleepiness; do not drive or operate heavy machinery until you know how it affects you.
  • Inform your doctor if you have kidney or liver disease, heart problems, or low blood sodium levels.
  • Women using hormonal contraceptives should be aware that Zenoxa 600 Tablet may reduce their effectiveness.
  • Consult your doctor if you are pregnant, planning to conceive, or breastfeeding, as it may be unsafe during these periods.
  • Monitor for unusual mood or behavior changes, depression, or suicidal thoughts.

• Storage: Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of sight and reach of children.

ZENOXA 600 Tablet contains oxcarbazepine as its active ingredient and is manufactured by Intas Pharmaceuticals Ltd.. It is an anticonvulsant medication primarily used to manage epilepsy and prevent seizures.

What is ZENOXA 600 Tablet used for?

ZENOXA 600 Tablet is used to treat and prevent partial seizures in adults and children with epilepsy. It can be prescribed alone (monotherapy) or in combination with other anti-epileptic medications (adjunctive therapy). It may also be used to manage generalized tonic-clonic seizures and has been used off-label for bipolar disorder.

How does ZENOXA 600 Tablet work?

ZENOXA 600 Tablet works by decreasing abnormal electrical activity in the brain. Its active metabolite, licarbazepine (MHD), primarily functions by blocking voltage-gated sodium channels, which helps to stabilize hyperexcited nerve membranes, inhibit repetitive neuronal firing, and reduce the spread of synaptic impulses that cause seizures. It may also enhance potassium conductance and modulate high-voltage activated calcium channels.

What is the usual dosage for ZENOXA 600 Tablet?

The dosage of ZENOXA 600 Tablet varies based on whether it's used alone or with other medications, and the patient's age and weight. For adults, the usual starting dosage for immediate-release formulations is 300 mg twice daily (600 mg per day), which may be gradually increased by your doctor. The maximum recommended daily dose can range from 1200 mg to 2400 mg, depending on the specific therapy and patient tolerance. For children, the dose is determined by body weight and adjusted by a doctor. It's crucial to follow your doctor's specific instructions.

What are the possible side effects of ZENOXA 600 Tablet?

Common side effects can include dizziness, drowsiness, headaches, nausea, vomiting, double vision, fatigue, and problems with balance or coordination. More serious but less common side effects can include severe low blood sodium (hyponatremia), serious skin reactions (like Stevens-Johnson syndrome), allergic reactions, and changes in mood or behavior, including suicidal thoughts. If you experience any severe or persistent side effects, contact your doctor immediately.

Is ZENOXA 600 Tablet safe during pregnancy or breastfeeding?

Pregnancy: Use during pregnancy may pose risks to the baby, although the risk may be less than uncontrolled seizures. Animal studies have shown potential for fetal abnormalities. However, some human pregnancy data has not shown a significantly increased chance of birth defects, but more robust data is needed. It is important to discuss the risks and benefits with your healthcare provider. Women taking oxcarbazepine during pregnancy should talk to their healthcare providers about taking vitamin K supplements near the end of their pregnancies.

Breastfeeding: Oxcarbazepine and its active metabolite pass into breast milk. While some reports suggest very low levels in breastfed infants and no observed problems, use is generally not recommended, or the decision should be made considering the importance of the drug to the mother versus potential effects on the infant. Monitor the infant for drowsiness or poor weight gain.

Can ZENOXA 600 Tablet be taken with other medications?

ZENOXA 600 Tablet can interact with various medications. It can decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, and injections), requiring alternative birth control methods. It can also interact with other seizure medications (e.g., phenytoin, carbamazepine, phenobarbital), certain blood pressure medications (e.g., felodipine, diltiazem), cyclosporine, and diuretics (which can increase the risk of low sodium). Combining it with alcohol, opioids, or benzodiazepines can increase the risk of drowsiness and dizziness. Always inform your doctor about all medications, supplements, and herbal products you are taking.

What precautions should be taken?

Do not stop taking ZENOXA 600 Tablet suddenly, as this can worsen seizures. Your doctor will likely decrease your dose gradually if discontinuation is necessary. Avoid alcohol as it can increase side effects like dizziness and drowsiness. This medication can cause dizziness and affect coordination, so exercise caution when driving or operating machinery. Your doctor may monitor your blood sodium levels, especially during initial treatment, as low sodium is a potential side effect. Individuals of Asian descent may have an increased risk of severe skin reactions.

What happens if a dose is missed?

If you miss a dose of ZENOXA 600 Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double doses to make up for a missed one, as this can increase the risk of side effects.

How should ZENOXA 600 Tablet be stored?

Store ZENOXA 600 Tablet in a closed container at room temperature, away from heat, moisture, and direct light. Do not freeze. For oral suspension, keep it in the original container and use it within 7 weeks of first opening the bottle.