Dapacose M 10 Mg Tablet (10 Tab)

Dapacose M 10 Tablet

Dapacose M 10 Tablet is an oral anti-diabetic medication manufactured by J.B. Chemicals & Pharmaceuticals Ltd. for the management of type 2 diabetes mellitus.

• Name

  • Brand Name: DAPACOSE M 10 MG TABLET
  • Common Name: Dapagliflozin and Metformin tablets

• Composition

  • Dapacose M 10 Tablet contains a fixed-dose combination of Dapagliflozin 10 mg and Metformin 500 mg.

• Uses Dapacose M 10 Tablet is prescribed for adults to:

  • Manage blood sugar levels in type 2 diabetes mellitus, particularly when diet and exercise alone are insufficient.
  • Improve glycemic control.
  • Reduce the risk of hospitalization due to heart failure in adults with type 2 diabetes who have established cardiovascular disease or multiple cardiovascular risk factors.
  • Help prevent long-term complications of diabetes such as kidney damage and nerve disorders.

• Dosage and Administration

  • Take Dapacose M 10 Tablet orally as directed by your doctor, usually once daily in the morning, with or without food.
  • Swallow the tablet whole with a glass of water; do not crush, chew, or break it.
  • The dosage is based on your medical condition and response to treatment.

• Side Effects

  • Common Side Effects: Nausea, vomiting, diarrhea, headache, dizziness, frequent urination, mild skin rash, itchy skin, stomach ache, loss of appetite, genital mycotic infections (fungal infections in the genital area), nasopharyngitis (sore throat, stuffy or runny nose), and urinary tract infections.
  • Serious Side Effects: Lactic acidosis (symptoms include severe tiredness, difficulty breathing, dizziness, lightheadedness, reduced body temperature, muscle cramps, and low blood pressure) and hypoglycemia (low blood sugar), especially when combined with insulin or other blood sugar-lowering medications.

• Precautions

  • Contraindications: Do not take Dapacose M 10 Tablet if you are allergic to dapagliflozin, metformin, or any other ingredients. It is not for type 1 diabetes, diabetic ketoacidosis, or patients with severe kidney or liver disease, recent heart attack, heart failure, severe infection, or uncontrolled diabetes.
  • Pregnancy and Breastfeeding: Not generally recommended during pregnancy (especially the second and third trimesters) or breastfeeding. Consult your doctor for alternative treatment options.
  • Alcohol: Avoid excessive alcohol consumption as it may increase the risk of lactic acidosis.
  • Drug Interactions: Inform your doctor about all medicines, supplements, or herbal products you are taking, especially diuretics, insulin, sulfonylureas, and certain injectable dyes used in radiology.
  • Other Warnings: Use with caution in elderly patients. Do not stop taking this medicine abruptly without consulting your doctor.

• Storage

  • Store in a cool and dry place, away from direct sunlight, typically between 10ºC to 25ºC or below 30ºC.
  • Keep out of sight and reach of children.

DAPACOSE M 10 MG TABLET contains a combination of two active ingredients, dapagliflozin and metformin, and is prescribed for the management of type 2 diabetes mellitus. It is manufactured by J.B. Chemicals & Pharmaceuticals Ltd.

What is Dapacose M 10 mg Tablet used for?

Dapacose M 10 mg Tablet is primarily used in adults for the treatment of type 2 diabetes mellitus, alongside a healthy diet and regular exercise, to improve blood sugar control. It is also prescribed to reduce the risk of hospitalization for heart failure in adults with type 2 diabetes and established cardiovascular disease or multiple cardiovascular risk factors. Additionally, it helps lower the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visits in patients with heart failure. For patients with chronic kidney disease at risk of progression, Dapacose M 10 mg Tablet can reduce the risk of worsening kidney disease, end-stage kidney disease, and cardiovascular death. It is not used for type 1 diabetes or diabetic ketoacidosis.

How does Dapacose M 10 mg Tablet work?

Dapacose M 10 mg Tablet contains two anti-diabetic medications: dapagliflozin and metformin.

• Dapagliflozin is a sodium-glucose cotransporter-2 (SGLT2) inhibitor. It works by preventing the kidneys from reabsorbing glucose (blood sugar) back into the bloodstream, leading to increased glucose excretion in the urine and thus lowering blood sugar levels.
• Metformin is a biguanide that reduces the amount of glucose produced by the liver, decreases the absorption of glucose from the intestines, and improves the body's sensitivity to insulin, allowing it to use sugar more effectively. Together, these two mechanisms provide comprehensive blood sugar control.

What is the usual dosage for Dapacose M 10 mg Tablet?

The dosage of Dapacose M 10 mg Tablet is individualized by your doctor based on your current treatment regimen and how well you tolerate the medicine. It is typically taken once daily in the morning with food. The tablets should be swallowed whole and not crushed, cut, or chewed, as they are often extended-release formulations. The maximum recommended daily dose is 10 mg of dapagliflozin and 2000 mg of metformin. If you are currently taking an evening dose of extended-release metformin, your doctor may advise you to skip that dose before starting Dapacose M.

What are the possible side effects of Dapacose M 10 mg Tablet?

Common side effects can include diarrhea, headache, nausea, vomiting, a runny or stuffy nose (nasopharyngitis), urinary tract infections, genital fungal infections (in both men and women), and increased urination. More serious side effects that require immediate medical attention include:

• Lactic acidosis: (rare but serious) Symptoms can include muscle pain or cramps, stomach pain, trouble breathing, general discomfort, unusual tiredness or weakness, cold feeling, and a slow or uneven heart rate.
• Diabetic ketoacidosis (DKA): Symptoms may include increased thirst or urination, dry mouth, fatigue, a fruity odor to your breath, trouble breathing, stomach pain, nausea, and vomiting.
• Dehydration/Hypotension: Signs include increased thirst, dry mouth, feeling faint or lightheaded, headache, dark yellow or brown urine, dizziness, and weakness.
• Allergic reactions: Manifest as skin rash, itching, hives, swelling of the face, lips, tongue, or throat, and trouble breathing.
• Kidney problems: Indicated by little or no urination, painful or difficult urination, and swelling in your feet or ankles.
• Fournier's gangrene: (a rare but severe bacterial infection of the genital area) Symptoms include pain, tenderness, redness, or swelling in the area between the anus and genitals, accompanied by fever.
• Hypoglycemia (low blood sugar): This is more common when Dapacose M is taken with insulin or other diabetes medications like sulfonylureas.

Is Dapacose M 10 mg Tablet safe during pregnancy or breastfeeding?

Pregnancy: Dapacose M 10 mg Tablet is not recommended during pregnancy, especially in the second and third trimesters, due to potential risks to the developing baby's kidneys observed in animal studies. Your doctor may suggest alternative diabetes medications, such as insulin or metformin alone, which are generally considered safe during pregnancy. Breastfeeding: This medication is not recommended for use while breastfeeding. Both dapagliflozin and metformin can pass into breast milk, and there is a theoretical risk that dapagliflozin could affect the infant's developing kidneys. Your doctor can discuss safer alternatives if you are breastfeeding.

Can Dapacose M 10 mg Tablet be taken with other medications?

Dapacose M 10 mg Tablet can interact with other medications. It is crucial to inform your doctor about all prescription, over-the-counter, herbal, and supplementary medications you are taking.

• Combining with insulin or insulin secretagogues (e.g., sulfonylureas) may increase the risk of low blood sugar (hypoglycemia), and dose adjustments for these medications may be necessary.
• Diuretics (water pills like furosemide or hydrochlorothiazide) may increase the risk of dehydration and low blood pressure.
• If you need an X-ray or CT scan involving iodinated contrast agents, you may need to temporarily stop taking Dapacose M before and after the procedure.
• Medications that decrease metformin clearance, such as cimetidine, ranolazine, dolutegravir, and vandetanib, can increase the levels of metformin in your body, potentially raising the risk of lactic acidosis.

What precautions should be taken while taking Dapacose M 10 mg Tablet?

Several precautions should be observed when taking Dapacose M 10 mg Tablet:

• Kidney Function: Your kidney function should be assessed before starting this medication and regularly monitored thereafter, as it is not recommended for individuals with severe kidney disease.
• Hydration: Ensure adequate fluid intake to avoid dehydration, especially if you experience fever, infection, vomiting, or diarrhea. Your doctor may need to adjust your medication if you become dehydrated.
• Alcohol Consumption: Limit or avoid excessive alcohol intake, as it can increase the risk of lactic acidosis and affect blood sugar control.
• Medical Procedures: Inform your doctor or dentist that you are taking this medication before any major surgery or imaging procedures that use iodinated contrast dye, as you may need to temporarily stop it.
• Monitoring: Regular blood and urine tests will be performed to monitor your blood sugar levels and check for any unwanted effects.
• Low Blood Sugar: Be aware of the symptoms of low blood sugar (hypoglycemia) and always carry a fast-acting source of sugar (e.g., glucose tablets, hard candy, fruit juice) to treat it quickly.
• Vitamin B12: Your doctor may recommend vitamin B12 supplementation, as metformin can sometimes lower vitamin B12 levels.
• Elderly Patients: Elderly patients may be more susceptible to side effects, and their dosage may require careful adjustment.

What happens if a dose of Dapacose M 10 mg Tablet is missed?

If you miss a dose of Dapacose M 10 mg Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should Dapacose M 10 mg Tablet be stored?

Store Dapacose M 10 mg Tablet in its original container at room temperature, away from excessive heat, moisture, and direct light. Do not freeze the medicine. Keep it out of the reach of children. Do not keep outdated or no longer needed medicine; consult your healthcare professional for proper disposal.