Sitamax Trio 10/100/500mg

SITAMAX TRIO 10/100/500MG by AJANTA PHARMA LIMITED is a combination medication prescribed for the management of Type 2 Diabetes Mellitus in adults.

Name

• Brand Name: Sitamax Trio 10/100/500 Tablet
• Manufacturer: AJANTA PHARMA LIMITED

Composition

Each tablet contains three active ingredients:

• Dapagliflozin 10 mg
• Sitagliptin 100 mg
• Metformin (as Metformin Hydrochloride) 500 mg

Uses

SITAMAX TRIO 10/100/500MG is used to improve blood sugar control in adults with Type 2 Diabetes Mellitus, particularly when diet and exercise alone are insufficient. It works by reducing the sugar produced by the liver, improving the body's sensitivity to insulin, increasing insulin release, and promoting the excretion of excess sugar through urine. This medication also helps lower the risk of cardiovascular events and kidney complications associated with diabetes.

Dosage and Administration

This medicine should be taken as advised by your doctor. Typically, it is taken orally, and tablets should be swallowed whole with a glass of water, without crushing, chewing, or breaking. It can be taken with or without food, but taking it with meals may help reduce gastrointestinal upset and consistent timing each day is recommended. Do not discontinue the medication without consulting your doctor.

Side Effects

Common side effects may include:

• Nausea, vomiting, diarrhea, abdominal pain
• Headache, dizziness, fatigue, weakness
• Hypoglycemia (low blood sugar), especially when taken with other antidiabetic medicines or alcohol
• Urinary tract infections and genital fungal infections
• Common cold, sore throat, upper respiratory tract infection

Serious but less common side effects include pancreatitis, severe allergic reactions, and lactic acidosis (symptoms like rapid breathing, stomach pain, muscle cramps).

Precautions

• Allergies: Avoid if allergic to any of the components.
• Kidney/Liver Disease: Not recommended for patients with severe liver or kidney disease. Use with caution and monitor function if you have kidney or liver issues.
• Pregnancy/Breastfeeding: Not recommended during pregnancy or breastfeeding due to limited information and potential risks; consult your doctor.
• Alcohol: Avoid excessive alcohol consumption as it increases the risk of lactic acidosis.
• Interactions: Inform your doctor about all medications, supplements, and herbs you are taking, as interactions can occur with drugs like insulin, sulfonylureas, rifampicin, digoxin, and certain diuretics.
• Dehydration: Drink plenty of fluids to prevent dehydration.
• Children: Not recommended for use in children below 18 years of age.

Storage

Store SITAMAX TRIO in a cool, dry place, away from direct heat and sunlight. Keep it out of the sight and reach of children and pets. It should be stored at temperatures between 10ºC to 25ºC or below 30ºC.

What is SITAMAX TRIO 10/100/500MG used for?

SITAMAX TRIO 10/100/500MG is a combination medicine primarily used for the management of type 2 diabetes mellitus in adults. It is prescribed when blood sugar levels are not adequately controlled by metformin alone, or by dual therapy with metformin and either dapagliflozin or sitagliptin. This medicine, along with diet and exercise, helps to improve blood sugar control, aids in weight management, and can help reduce cardiovascular risk.

How does SITAMAX TRIO 10/100/500MG work?

SITAMAX TRIO 10/100/500MG combines three active ingredients: Dapagliflozin, Sitagliptin, and Metformin, each working through different mechanisms to control blood sugar levels.

• Dapagliflozin (10mg): Increases the excretion of glucose from the body through urine.
• Sitagliptin (100mg): Enhances the levels of natural substances called incretins, which stimulate insulin release after meals and reduce glucagon secretion, thereby lowering blood sugar.
• Metformin (500mg): Works by decreasing the amount of glucose produced by the liver, reducing glucose absorption from the intestines, and improving the body's response to insulin.

What is the usual dosage of SITAMAX TRIO 10/100/500MG?

SITAMAX TRIO 10/100/500MG should be taken exactly as directed by your doctor. It can typically be taken with or without food, but taking it with meals is often recommended to reduce the risk of stomach upset. Swallow the tablet whole with a glass of water; do not crush, chew, or break it. It is best to take this medicine consistently at the same time each day for optimal benefits.

What are the possible side effects of SITAMAX TRIO 10/100/500MG?

Common side effects may include urinary tract infections, nasal congestion, sore throat, upper respiratory tract infections, and genital fungal infections. Other frequently reported side effects include diarrhea, nausea, headache, influenza-like symptoms, back pain, cough, and abdominal pain. Serious but less common side effects can include lactic acidosis, acute pancreatitis, severe allergic reactions, and hypoglycemia (especially when taken with other anti-diabetic medicines or alcohol).

Is SITAMAX TRIO 10/100/500MG safe during pregnancy or breastfeeding?

There is limited information regarding the safe use of SITAMAX TRIO 10/100/500MG during pregnancy, and it is generally not recommended for use in pregnant women. Similarly, breastfeeding is not recommended while taking this medication, as information on its passage into human breast milk is unavailable, and metformin is known to be present in human milk. Always consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Can SITAMAX TRIO 10/100/500MG be taken with other medications?

SITAMAX TRIO 10/100/500MG may interact with other medications. Caution should be exercised if you are taking diuretics (water pills), insulin, insulin secretagogues (like sulfonylureas), certain heart medications (such as digoxin or beta-blockers), medicines for fungal infections (e.g., ketoconazole), bacterial infections (e.g., clarithromycin), HIV/AIDS (e.g., ritonavir), blood pressure drugs, or steroids. Always inform your doctor about all other medicines, herbals, or supplements you are currently taking to avoid potential interactions.

What precautions should be taken while using SITAMAX TRIO 10/100/500MG?

Inform your doctor if you have kidney or liver issues, heart failure, type 1 diabetes, diabetic ketoacidosis, a history of acute pancreatitis, or if you experience allergic reactions. Avoid excessive alcohol consumption, as it can increase the risk of lactic acidosis. Staying hydrated by drinking plenty of fluids is essential to prevent dehydration, especially as one of the ingredients (Dapagliflozin) increases urinary glucose excretion. Regular monitoring of blood sugar levels and kidney function is crucial during treatment.

What happens if a dose of SITAMAX TRIO 10/100/500MG is missed?

If you miss a dose of SITAMAX TRIO 10/100/500MG, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should SITAMAX TRIO 10/100/500MG be stored?

SITAMAX TRIO 10/100/500MG should be stored in a cool and dry place, away from direct heat and sunlight. Keep it out of the reach of children and pets.