Siphene 100 Mg Tablet (5 Tab)

SIPHENE 100 MG TABLET (5 TAB)

Siphene 100 MG Tablet is a medication prescribed for the treatment of female infertility. It is manufactured by Serum Institute of India Pvt. Ltd.

• Name:

  • Brand Name: Siphene 100 MG Tablet
  • Common Name: Clomiphene (also known as Clomiphene Citrate)

• Composition:

  • Each tablet contains Clomiphene 100 mg.

• Uses: Siphene 100 MG Tablet is primarily used to treat female infertility in women who are unable to become pregnant due to problems with ovulation. It is effective in conditions such as:

  • Anovulation (lack of ovulation)
  • Irregular or no menstrual cycles
  • Polycystic Ovary Syndrome (PCOS) The medicine works as a selective estrogen receptor modulator (SERM) by stimulating the production and release of reproductive hormones (Follicle-Stimulating Hormone and Luteinizing Hormone) from the pituitary gland, which in turn promotes the normal development and release of a mature egg from the ovary (ovulation).

• Dosage and Administration:

  • Siphene 100 MG Tablet is taken orally, typically as prescribed by a doctor.
  • The usual dosage involves taking one tablet daily for five days.
  • For the first course of treatment, a 50 mg dose might be recommended, which can be increased to 100 mg in subsequent cycles if necessary, under medical supervision.
  • Treatment usually starts around the 5th day of the menstrual cycle, or at any time if there is no menstrual cycle.
  • The tablet should be swallowed whole with a glass of water, and can be taken with or without food, preferably at a fixed time.
  • It is generally not recommended for use for more than three menstrual cycles.

• Side Effects:

  • Common Side Effects: Flushing (hot flashes), abdominal bloating or discomfort, nausea, vomiting, headache, breast pain or tenderness, visual disturbances (blurred vision, spots or flashes), and enlarged ovaries. Some women may also experience irregular or heavy menstrual bleeding, or bleeding between periods.
  • Serious Side Effects (Seek immediate medical attention if experienced): Symptoms of Ovarian Hyperstimulation Syndrome (OHSS) such as severe lower abdominal pain with nausea or vomiting, weight gain, difficulty breathing, difficulty passing urine, significantly enlarged ovaries, or fluid build-up in the chest or abdomen. Allergic reactions like rash, swelling of lips, face, throat, or tongue leading to difficulty breathing or swallowing. Yellowing of the skin or eyes (jaundice) which may indicate liver problems.

• Precautions:

  • Contraindications: Siphene 100 MG Tablet is contraindicated in pregnant women (Category X drug) and a pregnancy test should be performed before initiating treatment. It should not be used by individuals with an allergy to clomiphene or any other ingredients, pre-existing liver disease, unexplained and unusual menstrual bleeding, hormone-dependent cancer, or ovarian cysts (not due to PCOS). It is also not recommended for children, adolescents, men, or post-menopausal women.
  • Warnings: Alcohol consumption should be avoided as it may worsen the condition and increase the risk of side effects. Due to potential vision problems like blurred vision, caution is advised when driving or operating heavy machinery. Use with caution during breastfeeding as it may decrease breast milk production. Patients with kidney problems, high blood fat levels, uterine fibroids, pituitary gland or brain tumors, thyroid or adrenal gland dysfunction, or a history of fits should use this medicine with caution. Regular medical monitoring, including ultrasound scans and hormone level tests, is essential during treatment. There is an increased risk of multiple pregnancies or ectopic pregnancy.

• Storage:

  • Keep Siphene 100 MG Tablet out of sight and reach of children.
  • Store in the original container below 25°C (some sources specify between 15°C and 30°C).
  • Protect from heat, light, and moisture.

Here are frequently asked questions about SIPHENE 100 MG TABLET:

What is Siphene 100 MG Tablet used for?

Siphene 100 MG Tablet is primarily used to treat female infertility. It is prescribed for women who are unable to get pregnant due to problems with ovulation (the release of an egg from the ovary) or who have irregular or absent menstrual cycles. This often includes women with Polycystic Ovary Syndrome (PCOS).

How does Siphene 100 MG Tablet work?

Siphene 100 MG Tablet contains Clomiphene Citrate, which is an ovulation stimulant. It works by acting as a selective estrogen receptor modulator (SERM). Clomiphene blocks estrogen receptors in the hypothalamus in the brain, making the body perceive estrogen levels as lower than they are. This "trick" stimulates the pituitary gland to produce more Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH), which are essential for the development and release of mature eggs from the ovaries (ovulation).

What is the usual dosage for Siphene 100 MG Tablet?

The typical dosage is one 50 mg tablet daily for 5 days, usually starting on the 5th day of your menstrual cycle. If you do not have a menstrual cycle, your doctor may advise you to start at any time. If ovulation does not occur after the first course, the dose may be increased to 100 mg daily for 5 days in subsequent cycles. It is generally not recommended to use this medicine for more than 3 to 6 treatment cycles. Always take it exactly as prescribed by your doctor. It can be taken with or without food.

What are the possible side effects of Siphene 100 MG Tablet?

Common side effects include hot flashes or flushing, abdominal discomfort or bloating, nausea, vomiting, headache, breast pain or tenderness, and visual disturbances like blurred vision or seeing spots/flashes. Other possible side effects include abnormal or heavy vaginal bleeding, painful periods, mood swings, weight gain, anxiety, and nervousness. Rarely, more severe side effects such as Ovarian Hyperstimulation Syndrome (OHSS) can occur, which presents with severe abdominal pain, weight gain, and difficulty breathing.

Is Siphene 100 MG Tablet safe during pregnancy or breastfeeding?

No, Siphene 100 MG Tablet is considered unsafe during pregnancy and is a Category X drug, meaning it should not be used by pregnant women as it may cause birth defects. A pregnancy test should be performed before starting treatment. It is also advised to use caution during breastfeeding as it may decrease breast milk production. Consult your doctor if you are breastfeeding.

Can Siphene 100 MG Tablet be taken with other medications?

It is important to inform your doctor about all other medications you are taking, including prescription drugs, over-the-counter medicines, herbal products, and supplements. This is to avoid potential drug interactions. Specific critical interactions mentioned include Ospemifene and severe interactions with Fluoroestradiol (18F).

What precautions should be taken while using Siphene 100 MG Tablet?

Do not take Siphene if you are allergic to Clomiphene or have certain conditions such as liver disease, unexplained vaginal bleeding, ovarian cysts (not due to PCOS), hormone-dependent cancers, a pituitary gland or other brain tumor, or uncontrolled thyroid or adrenal dysfunction. It should also not be used in children, adolescents, or post-menopausal women. If you experience vision problems (like blurred vision), avoid driving or operating heavy machinery. Alcohol consumption should be avoided. Your doctor will likely perform regular monitoring with blood tests and ultrasounds during treatment.

What happens if a dose of Siphene 100 MG Tablet is missed?

If you miss a dose, it is important to contact your doctor immediately for instructions, as you may need to adjust your treatment cycle. Do not take a double dose to make up for the missed one. Missing a single dose is generally unlikely to significantly impact your treatment.

How should Siphene 100 MG Tablet be stored?

Siphene 100 MG Tablet should be stored in its original container, in a cool and dry place below 25°C (or between 15 and 30 degrees C). Keep it out of sight and reach of children and pets, and protect it from heat, light, and moisture. Any unused medicine should be disposed of after the expiration date.