Glador M1 Forte

Name

• Common Name: Glador M1 Forte Tablet
• Brand Name: GLADOR M1 FORTE by Lupin Ltd.

Composition GLADOR M1 FORTE contains two active ingredients:

• Glimepiride (1 mg)
• Metformin (1000 mg)

Uses GLADOR M1 FORTE is primarily prescribed for the management of Type 2 Diabetes Mellitus in adults. It works as an adjunct to diet and exercise to improve glycemic control. Its uses include:

• Lowering blood sugar levels in individuals diagnosed with Type 2 Diabetes.
• Improving blood sugar control when diet, exercise, and single-agent medications are insufficient.
• Preventing serious diabetes-related complications such as kidney damage, eye problems, nerve issues, and limb amputations.
• Aiding in the reduction of cardiovascular risks, including heart attacks and strokes, in diabetic patients.
• Enhancing insulin sensitivity, making the body's tissues more responsive to insulin.

Dosage and Administration

• GLADOR M1 FORTE is taken orally, typically once a day.
• It should be swallowed whole with a glass of water, preferably with a meal (e.g., evening meal).
• Do not crush or chew the tablet.
• The exact dosage and duration of treatment should be determined by a physician, based on the patient's age, body weight, disease condition, and blood glucose levels.

Side Effects

• Common Side Effects: Stomach pain, nausea, diarrhea, vomiting, headache, metallic taste, and hypoglycemia (low blood sugar level). Most common side effects usually resolve over time.
• Serious Side Effects:
  • Lactic acidosis (accumulation of lactic acid in the body), which can be rare but serious. Symptoms may include deep or rapid breathing, persistent nausea, vomiting, and stomach pain.
  • Inflammation of the liver, which may result in jaundice (yellowing of skin or eyes).
  • Severe allergic reactions (e.g., rash, hives, increased sensitivity to sun, inflammation of blood vessels, difficulty breathing, fall in blood pressure).
• Other: Long-term use may lead to Vitamin B12 deficiency.

Precautions

• Contraindications:
  • Not recommended for individuals with Type 1 Diabetes Mellitus, diabetic ketoacidosis, or diabetic coma.
  • Should not be taken by those with severe kidney failure, severe liver failure, or metabolic acidosis (including lactic acidosis).
  • Contraindicated in pregnant or breastfeeding women as it may harm the unborn baby or pass into breast milk.
  • Should not be used if allergic to glimepiride, metformin, or any other components of the medicine.
  • Contraindicated in children and patients with heart disease.
• Warnings:
  • Avoid alcohol consumption, as it can increase the risk of lactic acidosis and hypoglycemia.
  • Monitor blood sugar levels regularly to prevent hypoglycemia. Be aware of hypoglycemia symptoms (e.g., sweating, dizziness, headache, shaking) and carry a fast-acting source of sugar.
  • Use with caution in older patients, as they may be more susceptible to side effects.
  • GLADOR M1 FORTE may decrease alertness; therefore, caution is advised when driving or operating machinery.
  • Inform your doctor about any pre-existing medical conditions (e.g., kidney or liver problems, circulation problems) or if taking other medications.
• Drug Interactions: Can interact with other antidiabetic agents (e.g., insulin, glibenclamide), ACE inhibitors (e.g., enalapril, lisinopril), and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) (e.g., ibuprofen, naproxen), potentially increasing the risk of hypoglycemia.

Storage

• Store in a cool and dry place, away from direct sunlight.
• Keep at temperatures between 10ºC to 25ºC or below 30ºC.
• Keep out of reach and sight of children.

GLADOR M1 FORTE by LUPIN LTD is a medication commonly prescribed for the management of Type 2 Diabetes Mellitus. Here are some frequently asked questions about this medicine:

What is GLADOR M1 FORTE used for?

GLADOR M1 FORTE is used in adults to manage Type 2 Diabetes Mellitus when diet and exercise alone, or other single agents, do not adequately control blood sugar levels. It helps improve blood sugar control and can reduce the risk of serious diabetes-related complications such as kidney damage, blindness, nerve problems, limb amputations, heart attacks, and strokes. It is not indicated for Type 1 Diabetes.

How does GLADOR M1 FORTE work?

GLADOR M1 FORTE is a combination medicine containing Glimepiride (1 mg) and Metformin (1000 mg). Glimepiride works by stimulating the pancreas to release more insulin and by increasing the sensitivity of the body's tissues to insulin, which helps absorb more glucose from the bloodstream. Metformin works by reducing the amount of glucose produced by the liver, delaying glucose absorption from the intestines, and further increasing the body's sensitivity to insulin.

What is the usual dosage of GLADOR M1 FORTE?

The usual dosage is typically one tablet taken once daily with a meal, preferably the evening meal. The tablet should be swallowed whole with a glass of water and not crushed or chewed. Your doctor will determine the exact dose and duration of treatment based on your condition and response to the medication, and you should not alter the dosage without medical advice.

What are the possible side effects of GLADOR M1 FORTE?

Common side effects may include diarrhea, nausea, vomiting, abdominal pain, headache, dizziness, a metallic taste in the mouth, and hypoglycemia (low blood sugar). Less common but serious side effects that require immediate medical attention include lactic acidosis (a build-up of lactic acid in the body), inflammation of the liver (which may cause jaundice), and severe allergic reactions.

Is GLADOR M1 FORTE safe during pregnancy or breastfeeding?

Pregnancy: GLADOR M1 FORTE is generally not recommended during pregnancy as it may be unsafe and could harm the unborn baby. The potential benefits versus risks should be discussed with a doctor.

Breastfeeding: It is generally not recommended during breastfeeding as it may pass into breast milk and potentially cause adverse effects in the baby. Some sources suggest it is safe, but due to conflicting information, it is best to consult your doctor to understand the potential risks and benefits.

Can GLADOR M1 FORTE be taken with other medications?

GLADOR M1 FORTE can interact with various medications. Other antidiabetic agents (like insulin or glibenclamide), ACE inhibitors (such as enalapril or lisinopril), and NSAIDs (like ibuprofen or naproxen) can enhance its blood glucose-lowering effects, increasing the risk of hypoglycemia. Diuretics can reduce its effectiveness. It should not be taken with Miconazole or Gatifloxacin due to the risk of severe side effects. Always inform your doctor about all medications you are currently taking.

What precautions should be taken while using GLADOR M1 FORTE?

You should avoid consuming alcohol while taking GLADOR M1 FORTE, as it can increase the risk of lactic acidosis and affect blood sugar levels. The medicine should be used with caution in patients with kidney or liver disease, and it is not recommended for those with severe conditions in these organs, Type 1 diabetes, or diabetic ketoacidosis. Regular monitoring of blood sugar levels and kidney/liver function tests may be advised. Also, GLADOR M1 FORTE is not suitable for children or adolescents under 18. If you experience dizziness or visual disturbances, avoid driving or operating machinery.

What happens if a dose of GLADOR M1 FORTE is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. Consult your doctor if you have any concerns about missed doses.

How should GLADOR M1 FORTE be stored?

GLADOR M1 FORTE should be stored at room temperature, ideally below 30°C. Keep the medication away from light and moisture to maintain its effectiveness. Always ensure it is kept out of the reach and sight of children. Do not use the medicine past its expiry date.