Xmet Trio 500/0.2/2 Tab

XMET TRIO 500/0.2/2 TAB

Name:

• Brand Name: Xmet Trio 500/0.2/2 TAB
• Manufacturer: Glenmark Pharmaceuticals Ltd.

Composition: Each tablet contains a combination of three active ingredients:

• Metformin Hydrochloride: 500 mg
• Glimepiride: 2 mg
• Voglibose: 0.2 mg

Uses: XMET TRIO 500/0.2/2 TAB is prescribed for the management of Type 2 Diabetes Mellitus in adults. It is typically used when diet, exercise, and single anti-diabetic medications are insufficient to adequately control blood sugar levels. It works by increasing insulin release from the pancreas, decreasing glucose production in the liver, and slowing down the absorption of carbohydrates from the intestines, thereby helping to lower both fasting and post-meal blood glucose levels.

Dosage and Administration: This medicine should be taken orally as directed by your doctor. It is generally recommended to swallow the tablet whole with a glass of water, with or immediately before meals, to minimize stomach upset. Do not crush, chew, or break the tablet. For optimal results, take it at a fixed time each day. The dosage will be determined by your doctor based on your blood sugar levels and response to treatment. Do not skip doses or stop taking the medicine abruptly without consulting your doctor.

Side Effects: Common side effects may include:

• Headache
• Nausea, vomiting, diarrhea
• Abdominal discomfort/pain, flatulence, dyspepsia (indigestion)
• Loss of appetite
• Metallic taste
• Hypoglycemia (low blood sugar), which can manifest as dizziness, weakness, hunger pangs, sweating, and shakiness.

Serious side effects, though rare, can include lactic acidosis (symptoms like extreme fatigue, body weakness, diarrhea, headache) and severe hypoglycemia.

Precautions:

• Contraindications: Do not take if you have an allergy to its ingredients, are pregnant or breastfeeding, have severe kidney or liver problems, Type 1 diabetes, diabetic ketoacidosis, acute metabolic acidosis, severe infection, severe trauma, lung problems, or certain heart conditions.
• Alcohol: Avoid alcohol consumption as it increases the risk of low blood sugar and lactic acidosis.
• Driving: This medicine may cause dizziness and visual disturbances; exercise caution when driving or operating machinery.
• Interactions: Inform your doctor about all other medications, including over-the-counter drugs and herbal supplements, as they may interact with XMET TRIO. Particular caution is needed with other anti-diabetic drugs, certain blood pressure medicines, painkillers, and corticosteroids.
• Monitoring: Regular monitoring of blood sugar levels, kidney function, and Vitamin B12 levels is crucial during treatment.

Storage: Store XMET TRIO 500/0.2/2 TAB below 25°C or 30°C, protected from light and moisture. Keep the medicine out of the reach and sight of children and pets, and store it in its original packaging.

What is XMET TRIO 500/0.2/2 Tablet used for?

XMET TRIO 500/0.2/2 Tablet is primarily used to treat Type 2 diabetes mellitus in adults. It is prescribed when diet, exercise, and single anti-diabetic medications are insufficient to adequately control blood sugar levels. This medicine helps manage high blood sugar, regulate post-meal glucose spikes, improve insulin sensitivity, enhance pancreatic insulin production, and reduce liver glucose production. It also helps prevent serious complications of diabetes such as kidney damage, eye damage, nerve problems, heart attack, and stroke.

How does XMET TRIO 500/0.2/2 Tablet work?

XMET TRIO 500/0.2/2 Tablet is a combination of three anti-diabetic medications: Glimepiride, Metformin, and Voglibose, which work together to control blood sugar levels.

• Glimepiride is a sulfonylurea that stimulates the pancreas to release more insulin, thereby lowering blood glucose levels.
• Metformin, a biguanide, works by decreasing glucose production in the liver, delaying glucose absorption from the intestines, and improving the body's sensitivity to insulin.
• Voglibose is an alpha-glucosidase inhibitor that slows down the breakdown of complex carbohydrates into simpler sugars in the small intestine, which delays glucose absorption and prevents sharp rises in blood sugar after meals.

What is the usual dosage of XMET TRIO 500/0.2/2 Tablet?

The dosage of XMET TRIO 500/0.2/2 Tablet should be strictly as advised by your doctor, as it can vary based on your condition and response to treatment. It is typically taken orally, once or twice daily, with or immediately before meals to minimize stomach upset. The tablet should be swallowed whole with a glass of water and not crushed, chewed, or broken. For optimal results, it is recommended to take it at the same time each day.

What are the possible side effects of XMET TRIO 500/0.2/2 Tablet?

Common side effects of XMET TRIO 500/0.2/2 Tablet can include hypoglycemia (low blood glucose levels), dizziness, sweating, hunger pangs, taste changes, nausea, vomiting, diarrhea, stomach pain, abdominal discomfort, flatulence, and headache. Hypoglycemia is a common side effect, characterized by dizziness, sweating, hunger pangs, and dry mouth and skin. If these effects persist or worsen, it is important to consult your doctor.

Is XMET TRIO 500/0.2/2 Tablet safe during pregnancy or breastfeeding?

XMET TRIO 500/0.2/2 Tablet is generally not recommended during pregnancy, especially in the second and third trimesters, as it may cause harm to the fetus. Similarly, it is probably unsafe to use during breastfeeding, as components of the medicine may pass into breast milk and harm the baby. It is crucial to inform your doctor if you are pregnant, planning to conceive, or breastfeeding before starting this medication.

Can XMET TRIO 500/0.2/2 Tablet be taken with other medications?

XMET TRIO 500/0.2/2 Tablet can interact with various other medications. Taking it with other anti-diabetic medicines, such as insulin or pioglitazone, may increase the risk of low blood sugar (hypoglycemia). Certain medications like amiloride, digoxin, morphine, and ranitidine may interfere with metformin. Hyperglycemia-inducing medicines such as estrogens, phenytoin, and isoniazid may affect the glucose-controlling effect of XMET TRIO. Corticosteroids (e.g., prednisolone, dexamethasone) and thiazide diuretics (e.g., hydrochlorothiazide, indapamide) can reduce the effectiveness of this tablet. Oral contraceptives may also reduce its blood glucose-lowering effect. Always inform your doctor about all medicines, supplements, or herbal products you are currently taking to prevent potential interactions.

What precautions should be taken while taking XMET TRIO 500/0.2/2 Tablet?

Several precautions should be taken when using XMET TRIO 500/0.2/2 Tablet:

• Avoid consuming alcohol, as it can increase the risk of low blood sugar (hypoglycemia) and a serious condition called lactic acidosis.
• It is contraindicated if you have severe kidney or liver disease, type 1 diabetes mellitus, diabetic ketoacidosis, acute metabolic acidosis, or severe infections. Caution is advised for mild to moderate liver impairment.
• Inform your doctor if you have a history of heart disease, pancreatitis, or low vitamin B12 levels.
• Do not stop taking the medicine abruptly without consulting your doctor, as this can lead to increased blood sugar levels and potential complications.
• If you experience dizziness or visual disturbances, avoid driving or operating machinery.
• Regular monitoring of blood sugar levels, kidney function, and vitamin B12 levels may be recommended by your doctor.

What happens if a dose of XMET TRIO 500/0.2/2 Tablet is missed?

If you miss a dose of XMET TRIO 500/0.2/2 Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should XMET TRIO 500/0.2/2 Tablet be stored?

XMET TRIO 500/0.2/2 Tablet should be stored in a cool and dry place, away from direct sunlight, at a temperature below 25°C or 30°C. Keep the medicine out of the sight and reach of children and pets.

What are the lifestyle recommendations while on XMET TRIO 500/0.2/2 Tablet?

While taking XMET TRIO 500/0.2/2 Tablet, it is crucial to maintain a healthy lifestyle. This includes following a balanced diet low in simple sugars to help control blood glucose levels. Regular physical activity, such as brisk walking or cycling, can also help improve your body's insulin sensitivity and support better blood glucose control. You must continue following the diet and exercise recommended by your doctor alongside your medication. It's also advisable to carry a source of sugar (like glucose tablets or juice) to manage potential low blood sugar episodes.