Valentas 100 Tablet

Valentas 100 Tablet

Valentas 100 Tablet, manufactured by Lupin Ltd., is a combination medication used primarily for the treatment of chronic heart failure. It is an Angiotensin Receptor Neprilysin Inhibitor (ARNI) that helps improve heart function and reduce the risk of cardiovascular events.

• Name:

  • Brand Name: Valentas 100 Tablet
  • Common Name: Sacubitril and Valsartan

• Composition:

  • Each tablet contains Sacubitril 49 mg and Valsartan 51 mg.

• Uses: Valentas 100 Tablet is prescribed for:

  • Treating chronic heart failure in adults, particularly those with reduced ejection fraction (NYHA Class II-IV).
  • Reducing the risk of cardiovascular death and hospitalization in patients with heart failure.
  • Aiding in hypertension management and providing cardiovascular protection by lowering blood pressure and reducing the risk of heart attacks and strokes.

• Dosage and Administration:

  • The dosage is determined by a physician based on the patient's medical condition and response to treatment.
  • It can be taken with or without food.
  • Tablets should be swallowed whole with a glass of water; they should not be chewed, crushed, or broken.
  • Adhere strictly to the prescribed regimen and do not exceed the recommended dose.

• Side Effects: Common side effects may include:

  • Dizziness, light-headedness (hypotension).
  • Cough.
  • Nausea, diarrhea.
  • Weakness, tiredness, headache.
  • High levels of potassium in the blood (hyperkalaemia).
  • Impaired renal function (kidney problems). Serious but rare side effects include angioedema (swelling of the face, lips, tongue, or throat).

• Precautions:

  • Pregnancy and Breastfeeding: Not recommended during pregnancy, especially after the first 3 months, as it can cause serious harm to the baby. It is also not recommended for breastfeeding women.
  • Drug Interactions: Avoid taking with ACE inhibitors (such as captopril or enalapril); a 36-hour washout period is required before or after taking an ACE inhibitor. Use with caution with aliskiren, lithium, and potassium-containing supplements.
  • Medical Conditions: Inform your doctor if you have kidney or liver diseases, or diabetes.
  • Orthostatic Hypotension: Rise slowly from a sitting or lying position to prevent dizziness due to a sudden drop in blood pressure.
  • Driving: May cause dizziness; avoid driving or operating heavy machinery until you know how the medicine affects you.

• Storage:

  • Store in a cool and dry place, ideally below 30°C.
  • Keep in the original packaging to protect from moisture and light.
  • Keep out of the sight and reach of children.

VALENTAS 100 TABLET by LUPIN LTD.: Frequently Asked Questions

VALENTAS 100 TABLET is a prescription medication used primarily to treat chronic heart failure. It is a combination of two active ingredients, Sacubitril and Valsartan, which work together to improve heart function and reduce symptoms associated with heart failure.

What is VALENTAS 100 TABLET used for?

VALENTAS 100 TABLET is primarily used to treat chronic heart failure with reduced ejection fraction, a condition where the heart struggles to pump blood effectively. It aims to reduce the risk of cardiovascular death and hospitalization in adults with this condition. The medicine may also help in lowering high blood pressure and improving outcomes in certain heart conditions.

How does VALENTAS 100 TABLET work?

VALENTAS 100 TABLET contains Sacubitril (49 mg) and Valsartan (51 mg). Sacubitril is a neprilysin inhibitor that works by blocking the enzyme neprilysin, which increases the levels of beneficial peptides. These peptides help relax and widen blood vessels, enhance sodium and water excretion, and decrease cardiac stress. Valsartan is an angiotensin II receptor blocker (ARB) that blocks the action of angiotensin II, a hormone that narrows blood vessels and increases blood pressure and cardiac stress. Together, these actions improve heart pumping efficiency, promote vasodilation, reduce blood pressure, and inhibit the harmful effects of angiotensin II, leading to improved cardiac function.

What is the usual dosage of VALENTAS 100 TABLET?

The daily dose of VALENTAS 100 TABLET should be taken as prescribed by your doctor. The dosage can vary based on individual factors, such as the severity of your condition and your response to the medicine. It can be taken with or without food, ideally at the same time each day for maximum benefit. Always follow your doctor's instructions precisely and do not change or exceed the prescribed dose without consultation.

What are the possible side effects of VALENTAS 100 TABLET?

Common side effects include dizziness, light-headedness (due to low blood pressure), high potassium levels in the blood (hyperkalaemia), cough, decreased kidney function, diarrhea, tiredness, weakness, headache, fainting, nausea, and stomach pain. More serious but rare side effects can include severe allergic reactions such as angioedema (swelling of the face, lips, tongue, or throat). If any side effects worsen or persist, it is important to consult your doctor.

Is VALENTAS 100 TABLET safe during pregnancy or breastfeeding?

VALENTAS 100 TABLET is generally not recommended during pregnancy or breastfeeding due to potential risks to the baby. It is contraindicated in pregnancy, especially after the first 3 months, as it may cause harm to the developing fetus. Women of childbearing potential should use effective contraception while taking this medicine. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor for alternative treatments.

Can VALENTAS 100 TABLET be taken with other medications?

VALENTAS 100 TABLET can interact with several other medications. It should not be used in combination with ACE inhibitors or within 36 hours of switching from or to an ACE inhibitor. Concomitant use with potassium-sparing diuretics (like spironolactone, amiloride), NSAIDs (like ibuprofen, naproxen), and lithium can increase the risk of hyperkalemia, renal impairment, or lithium toxicity, respectively. Patients with diabetes taking aliskiren should also avoid VALENTAS 100 TABLET due to increased potassium levels. Always inform your doctor about all medicines, including prescription, over-the-counter drugs, herbal supplements, and vitamins, you are currently taking to avoid potential drug interactions.

What precautions should be taken with VALENTAS 100 TABLET?

Inform your doctor if you have kidney or liver impairment, a history of angioedema, or diabetes. Regular monitoring of blood pressure and kidney function may be advised. Avoid consuming high-potassium foods or supplements, and limit or avoid alcohol consumption, as it may enhance blood pressure-lowering effects and lead to dizziness. Rise slowly from a sitting or lying position to prevent dizziness due to low blood pressure.

What happens if a dose of VALENTAS 100 TABLET is missed?

If you miss a dose of VALENTAS 100 TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, and never adjust your dosage without consulting your doctor.

How should VALENTAS 100 TABLET be stored?

Store VALENTAS 100 TABLET at room temperature, ideally below 30°C (or between 20-25°C), in its original packaging to protect it from moisture and light. Keep the medicine out of reach of children and pets, and check the expiry date before use.