Intagesic Mr Tablet (10 Tab)

INTAGESIC MR TABLET

INTAGESIC MR TABLET is a combination medication designed to provide relief from pain, inflammation, and muscle spasms associated with various musculoskeletal conditions. It is manufactured by INTAS PHARMACEUTICALS LTD..

Composition Each tablet of Intagesic-MR typically contains a fixed-dose combination of three active ingredients:

• Diclofenac Sodium: 50 mg (a non-steroidal anti-inflammatory drug or NSAID)
• Paracetamol (Acetaminophen): 325 mg (an analgesic and antipyretic)
• Chlorzoxazone: 250 mg (a muscle relaxant)

Uses Intagesic-MR Tablet is prescribed for relieving pain and inflammation, and alleviating muscle stiffness or spasms in conditions such as:

• Arthritis, spondylitis, and injuries
• Musculoskeletal pain, including back pain, joint pain, muscle pain, sprains, and strains
• Post-surgical pain, inflammation, and swelling
• Headaches and menstrual cramps

Dosage and Administration The tablet should be taken orally as directed by a healthcare professional.

• Typical Guidance: Usually, one tablet two to three times daily.
• Administration: It is recommended to take the tablet with or after food to minimize stomach upset.
• Method: Swallow the tablet whole with a glass of water; do not chew, crush, or break it.
• Important: Do not exceed the prescribed dosage or duration.

Side Effects Common side effects may include:

• Drowsiness, dizziness, lightheadedness
• Nausea, vomiting, stomach pain, indigestion, diarrhea, constipation
• Heartburn, flatulence, burping
• Headache, weakness, fatigue
• Rash, itching

More serious side effects can include liver problems, ulcers in the stomach or intestines, bleeding/perforation, and abnormal liver function tests.

Precautions

• Allergies: Do not take if allergic to diclofenac, paracetamol, chlorzoxazone, aspirin, or other NSAIDs.
• Alcohol: Avoid alcohol consumption as it may increase the risk of stomach bleeding and liver damage, and can enhance drowsiness.
• Pregnancy and Breastfeeding: Generally not recommended during pregnancy (especially the third trimester) and breastfeeding. Consult a doctor.
• Driving and Machinery: Avoid driving or operating heavy machinery if experiencing dizziness or drowsiness.
• Underlying Conditions: Not recommended for patients with severe liver, kidney, or heart disease, active gastric ulcers/bleeding problems, nasal polyps, or aspirin-sensitive asthma. Use with caution in patients with pre-existing asthma, COPD, mild to moderate liver or kidney disease, and high blood pressure.
• Overdosage: Taking more than the recommended dose can lead to serious liver problems.

Storage Store in a cool and dry place, away from direct sunlight. Keep out of sight and reach of children and pets. The typical storage temperature is below 30°C.

What is INTAGESIC MR Tablet used for?

INTAGESIC MR Tablet is primarily used to relieve pain, inflammation, and muscle stiffness or spasms associated with various conditions such as arthritis, spondylitis, injuries, headaches, and menstrual cramps. It is also used for relieving post-surgical pain, inflammation, and swelling.

How does INTAGESIC MR Tablet work?

INTAGESIC MR Tablet is a combination medication containing Diclofenac, Paracetamol (Acetaminophen), and Chlorzoxazone. Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), works by reducing the production of chemical messengers (cyclo-oxygenase or COX) responsible for pain and swelling. Paracetamol acts as a mild pain and fever reducer, enhancing the pain-relieving action of Diclofenac. Chlorzoxazone is a muscle relaxant that helps by blocking nerve impulses or pain sensations sent by the brain and spinal cord, thereby promoting muscle relaxation and improving muscle movement.

What is the usual dosage for INTAGESIC MR Tablet?

The dosage of INTAGESIC MR Tablet should be taken as advised by your doctor, usually one tablet two to three times daily. It is generally recommended to take it with or after food to minimize stomach upset. The tablet should be swallowed whole with a glass of water and not chewed, crushed, or broken. It's crucial not to exceed the recommended dosage or duration of use.

What are the possible side effects of INTAGESIC MR Tablet?

Common side effects of INTAGESIC MR Tablet can include dizziness, lightheadedness, nausea, vomiting, stomach pain, heartburn, diarrhea, loss of appetite, weakness, fatigue, headache, rash, drowsiness, constipation, and slight discoloration of urine. If any of these side effects persist or worsen, it is important to consult your doctor.

Is INTAGESIC MR Tablet safe during pregnancy or breastfeeding?

INTAGESIC MR Tablet is generally not recommended for use during pregnancy, especially in the third trimester, as it may cause defects in the baby's heart, delay delivery, or increase the risk of bleeding. It is also not recommended for use in breastfeeding women as it may pass into breast milk and cause serious side effects in the child. It is crucial to consult your doctor before taking this medicine if you are pregnant, planning a pregnancy, or breastfeeding.

Can INTAGESIC MR Tablet be taken with other medications?

Caution is advised when taking INTAGESIC MR Tablet with other medications. It should generally not be taken with other painkillers, especially those containing NSAIDs (like aspirin), without medical advice, as this can increase the risk of stomach ulcers or bleeding. It can interact with medicines like water pills (diuretics), leading to kidney damage. It may also increase the levels of lithium and methotrexate. Medicines used to modify immune responses during organ transplants, such as ciclosporin and tacrolimus, can result in kidney damage if taken with this medicine. Inform your doctor about all medications, including over-the-counter drugs and herbal supplements, you are currently taking.

What precautions should be taken while using INTAGESIC MR Tablet?

Several precautions should be taken while using INTAGESIC MR Tablet:

• Medical Conditions: Inform your doctor if you have kidney, liver, or heart problems (like high blood pressure or heart failure), gastrointestinal problems (like ulcers, bleeding, or Crohn's disease), or asthma, as the medicine can worsen these conditions or increase risks.
• Allergies: Do not take this medicine if you are allergic to diclofenac, paracetamol, chlorzoxazone, or other painkillers like aspirin.
• Alcohol: Avoid consuming alcohol while taking INTAGESIC MR Tablet, as it can increase the risk of stomach bleeding, liver damage, and may cause excessive drowsiness and dizziness.
• Driving: This medicine may cause dizziness or drowsiness; therefore, avoid driving or operating machinery if you experience these symptoms.
• Elderly Patients: Elderly patients should use this medicine with caution as they may be more susceptible to side effects.

What happens if a dose of INTAGESIC MR Tablet is missed?

If you miss a dose of INTAGESIC MR Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should INTAGESIC MR Tablet be stored?

INTAGESIC MR Tablet should be stored in a cool, dry place, below 30°C, and away from direct sunlight. It should be kept in its original packaging and out of the sight and reach of children and pets.