Ampanel 2 Mg Tablet (10 Tab)

AMPANEL 2 MG TABLET

AMPANEL 2 MG TABLET, manufactured by SUN PHARMA LABORATORIES LTD., contains the active ingredient Perampanel. It is an anti-epileptic medication used in the management of seizures.

Composition

Each tablet contains Perampanel 2mg.

Uses

AMPANEL 2 MG TABLET is prescribed as an adjunctive therapy (used in combination with other antiepileptic drugs) for:

• Partial-onset seizures with or without secondary generalized seizures in patients aged 4 years and older.
• Primary generalized tonic-clonic seizures in patients aged 7 years and older. It works by blocking specific glutamate receptors in the brain, thereby suppressing abnormal and excessive nerve cell activity that leads to seizures.

Dosage and Administration

This medicine is typically taken orally once daily, preferably at bedtime, with or without food. The tablet should be swallowed whole and not chewed, crushed, or broken. The dosage is determined by a healthcare professional and may be gradually increased based on individual response and tolerance. It is crucial to adhere to the prescribed schedule and not to stop the medication suddenly, as this can increase seizure frequency.

Side Effects

Common side effects may include:

• Dizziness, drowsiness, fatigue
• Increased or decreased appetite, weight gain
• Feeling aggressive, angry, irritable, anxious, or confused
• Difficulty with walking or balance (ataxia, gait disturbance, balance disorder)
• Slow speech (dysarthria)
• Blurred or double vision (diplopia), vertigo (spinning sensation)
• Nausea, back pain, headache

Serious side effects can include:

• Extreme mood changes, increased aggressive behavior, or suicidal thoughts
• Severe skin rash, skin peeling, blistering, or mouth sores

Precautions

• Contraindications: AMPANEL 2 MG TABLET is not recommended for individuals with severe liver problems, moderate to severe kidney issues, a known allergy to perampanel, or those who have previously experienced a severe skin rash, skin peeling, blistering, or mouth sores after taking perampanel.
• Alcohol: Avoid consuming alcohol, as it can heighten dizziness and drowsiness and may increase the risk of seizures.
• Driving and Machinery: Due to potential dizziness and drowsiness, avoid driving or operating heavy machinery until you understand how the medicine affects you.
• Pregnancy and Breastfeeding: This medicine is generally not recommended during pregnancy or for breastfeeding mothers. Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding.
• Other Conditions: Use with caution in patients with a history of substance abuse, kidney disease, or existing mental health conditions.
• Pediatric Use: Not recommended for children under 4 years for partial seizures and under 7 years for generalized seizures.
• Drug Interactions: Inform your doctor about all other medications you are taking, including other anti-epileptics (e.g., carbamazepine, phenytoin), rifampicin, St. John's Wort, ketoconazole, and hormonal contraceptives, as interactions may occur.

Storage

Store AMPANEL 2 MG TABLET at room temperature (below 30°C) and keep it out of the reach of children. Protect from light and moisture.

What is AMPANEL 2 MG TABLET used for?

AMPANEL 2 MG TABLET is an antiepileptic medication primarily used to treat epilepsy and seizures. It is effective for managing partial seizures, which can occur with or without generalized seizures, as well as generalized seizures. This medication is often used as an add-on therapy in combination with other antiepileptic drugs for adults, adolescents, and children (typically aged 4 years and above for partial seizures and 7 years and above for generalized seizures).

How does AMPANEL 2 MG TABLET work?

AMPANEL 2 MG TABLET contains the active ingredient Perampanel. It works by selectively blocking a specific type of glutamate receptor in the brain, known as the AMPA receptor. By doing so, it helps to regulate and suppress the excessive and abnormal electrical activity of nerve cells in the brain that lead to seizures.

What is the usual dosage for AMPANEL 2 MG TABLET?

AMPANEL 2 MG TABLET is typically taken orally once daily, preferably before bedtime, with or without food. The usual starting dose for adults is 2 mg once daily, which your doctor may gradually increase based on your response and tolerance, up to a maximum of 12 mg per day. It is crucial to follow your doctor's prescribed dosage and schedule and not to stop the medication suddenly.

What are the possible side effects of AMPANEL 2 MG TABLET?

Common side effects may include dizziness, drowsiness, fatigue, anger, nausea, balance disorders (such as difficulty walking or unsteadiness), weight gain, increased or decreased appetite, irritability, anxiety, and confusion. More severe but less common side effects can include suicidal thoughts or behaviors, significant changes in mood or behavior (e.g., aggression, hostility), and rare severe skin reactions like Stevens-Johnson syndrome or DRESS syndrome. If you experience any severe or persistent side effects, or unusual changes in mood, contact your doctor immediately.

Is AMPANEL 2 MG TABLET safe during pregnancy or breastfeeding?

AMPANEL 2 MG TABLET is generally not recommended during pregnancy or for women who are planning to become pregnant. It is also not recommended during breastfeeding, as the drug may pass into breast milk and potentially harm the baby. Women of child-bearing potential should use reliable contraception during treatment with AMPANEL 2 MG TABLET and for at least one month after stopping the medication. Always consult your doctor for advice if you are pregnant, planning pregnancy, or breastfeeding.

Can AMPANEL 2 MG TABLET be taken with other medications?

AMPANEL 2 MG TABLET can interact with several other medications. It may reduce the effectiveness of certain hormonal contraceptives, such as those containing levonorgestrel. Other antiepileptic medications like carbamazepine, oxcarbazepine, phenytoin, and felbamate, as well as drugs like rifampicin, St. John's Wort, and ketoconazole, may also interact with AMPANEL 2 MG TABLET, potentially affecting its levels or effectiveness. Always inform your doctor about all other medications, including over-the-counter drugs and herbal remedies, you are taking.

What precautions should be taken while taking AMPANEL 2 MG TABLET?

Do not stop taking AMPANEL 2 MG TABLET suddenly, as this can increase the frequency of seizures. Avoid consuming alcohol while on this medication, as it can worsen side effects like dizziness and drowsiness and may increase the risk of seizures. Exercise caution when driving or operating heavy machinery until you know how the medicine affects you, as it can cause dizziness and sleepiness. Inform your doctor if you have kidney or liver problems, a history of depression, suicidal thoughts, or substance abuse. Regular monitoring of kidney function may be necessary.

What happens if a dose of AMPANEL 2 MG TABLET is missed?

If you miss a dose of AMPANEL 2 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should AMPANEL 2 MG TABLET be stored?

AMPANEL 2 MG TABLET should be stored in its original package at room temperature, ideally below 30°C. Keep the tablets dry and protected from direct sunlight, heat, and moisture. Do not refrigerate or freeze the medicine. Always keep it out of the reach of children. Ensure you check the expiry date and do not use the medicine if it has expired.