Clofranil 25 Mg Tablet (10 Tab)

CLOFRANIL 25 MG TABLET

CLOFRANIL 25 MG TABLET, manufactured by Sun Pharma Laboratories Ltd., is a tricyclic antidepressant primarily used to treat various psychological conditions.

• Name:

  • Brand Name: Clofranil 25 MG Tablet
  • Common Name (Active Ingredient): Clomipramine

• Composition:

  • Each tablet contains Clomipramine (25 mg).

• Uses: CLOFRANIL 25 MG TABLET is prescribed for a range of mental health conditions by increasing the activity of serotonin and noradrenaline in the brain, which are chemical messengers involved in mood, behavior, and emotions.

  • Obsessive-Compulsive Disorder (OCD): Helps reduce persistent unwanted thoughts and repetitive behaviors.
  • Depression: Improves mood, energy, and motivation.
  • Panic and Anxiety Disorder: Alleviates symptoms such as fear, panic, nervousness, and restlessness.
  • Cataplexy associated with narcolepsy (a sleep disorder causing muscle weakness).
  • Phobic states.
  • Chronic pain (e.g., central pain, idiopathic pain disorder, tension headache, diabetic peripheral neuropathy, neuropathic pain).

• Dosage and Administration:

  • Typically taken with food, as prescribed by your doctor.
  • Swallow the tablet whole with water; do not break, crush, or chew.
  • For adults with OCD, the initial dose is often 25 mg once daily at bedtime. Dosage may be adjusted, usually not exceeding 250 mg per day.
  • For children 10 years and older with OCD, the initial dose is 25 mg once daily at bedtime, with a maximum of 200 mg per day.
  • Take at approximately the same time each day.
  • Do not stop taking the medicine abruptly, as it may cause withdrawal symptoms.

• Side Effects: Many side effects do not require medical attention and often resolve over time.

  • Common: Dizziness, headache, drowsiness, dry mouth, nausea, constipation, weight gain, increased sweating, shaking/tremor, blurred vision, erectile dysfunction, difficulty in urination, tiredness, stomach upset, low sex drive.
  • Serious (Seek medical attention if experienced): Severe allergic reactions, suicidal thoughts or behavior (especially in children, adolescents, and young adults), serotonin syndrome, heart rhythm changes, low sodium levels, neuroleptic malignant syndrome, blood disorders.

• Precautions:

  • Avoid if allergic to clomipramine or any components.
  • Not recommended for children below 17 years of age for general use.
  • Avoid during pregnancy and breastfeeding unless essential, as it may harm the fetus or infant.
  • Caution is advised in elderly patients and those with heart, kidney, or liver problems, low blood pressure, glaucoma, or a history of seizures.
  • Do not take with Monoamine Oxidase Inhibitors (MAOIs); a 14-day gap is required between stopping MAOIs and starting Clofranil.
  • Avoid alcohol and grapefruit/cranberry juice.
  • May impair the ability to drive or operate machinery due to dizziness or drowsiness.
  • Inform your doctor about all medications and pre-existing medical conditions.

• Storage:

  • Store in a cool and dry place, away from direct sunlight.
  • Keep out of sight and reach of children.
  • Store at temperatures between 10ºC to 25ºC or below 30ºC.

CLOFRANIL 25 MG TABLET (Clomipramine) is a tricyclic antidepressant medication primarily used to treat various mental health conditions.

What is CLOFRANIL 25 MG TABLET used for?

CLOFRANIL 25 MG TABLET is primarily used to treat Obsessive-Compulsive Disorder (OCD), a mental health condition characterized by persistent unwanted thoughts (obsessions) and repetitive behaviors (compulsions). It is also used to treat depression, including cases that have not responded to other medications. Additionally, it can be used for panic disorder, anxiety disorder, phobias, and muscular weakness (cataplexy) associated with narcolepsy (a sleep disorder).

How does CLOFRANIL 25 MG TABLET work?

CLOFRANIL 25 MG TABLET contains Clomipramine, which belongs to a class of medicines called tricyclic antidepressants (TCAs). It works by increasing the levels of natural chemical messengers in the brain, specifically serotonin and norepinephrine. By blocking the reuptake of these neurotransmitters, it enhances their availability in the synaptic cleft, helping to regulate mood, behavior, and emotions, thereby relieving symptoms of depression, anxiety, and obsessive-compulsive behaviors.

What is the usual dosage of CLOFRANIL 25 MG TABLET?

For adults with obsessive-compulsive disorder, the typical starting dosage is 25 mg once a day at bedtime. Your doctor may gradually increase the dose, usually up to 100 mg per day over the first two weeks, and potentially up to a maximum of 250 mg per day. For children aged 10 years and older, the initial dose is also 25 mg once daily, which can be increased gradually to a maximum of 3 mg/kg/day or 200 mg/day (whichever is less). The total daily dose is often taken at bedtime to help manage drowsiness. It is crucial to follow your doctor's specific instructions for dosage and administration.

What are the possible side effects of CLOFRANIL 25 MG TABLET?

Common side effects include dry mouth, constipation, nausea, dizziness, drowsiness, headache, increased sweating, tremors, blurred vision, increased appetite, and weight gain. Some men may experience problems with ejaculation or impotence, and both men and women may experience decreased sexual desire. More serious, but less common, side effects include suicidal thoughts or actions (especially in young adults), heart rhythm changes, serotonin syndrome (agitation, hallucinations, rapid heart rate, sweating), seizures, low sodium levels, and allergic reactions. If any severe side effects occur, seek immediate medical attention.

Is CLOFRANIL 25 MG TABLET safe during pregnancy or breastfeeding?

CLOFRANIL 25 MG TABLET is generally not recommended during pregnancy unless considered necessary by a physician, as it may cause harm to the fetus. It is probably unsafe to use during breastfeeding, as Clomipramine may be excreted in human milk and cause adverse effects in the baby. It is essential to consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding to discuss the risks and benefits.

Can CLOFRANIL 25 MG TABLET be taken with other medications?

CLOFRANIL 25 MG TABLET should not be taken with Monoamine Oxidase Inhibitors (MAOIs), or within 14 days of stopping them, due to the risk of life-threatening serotonin syndrome. Caution is also advised with other antidepressants (SSRIs, SNRIs), diuretics, certain pain medications (e.g., tramadol), and medicines that prolong the QT interval. Inform your doctor about all medications, including over-the-counter drugs and herbal supplements (like St. John's wort), you are taking to avoid potential interactions.

What precautions should be taken while using CLOFRANIL 25 MG TABLET?

This medication can cause drowsiness, dizziness, or blurred vision, so avoid driving or operating heavy machinery until you know how it affects you. Alcohol consumption should be avoided as it can increase sedative effects. Use with caution if you have heart disease, seizure disorders, glaucoma, liver or kidney problems, diabetes, or difficulty urinating. There is an increased risk of suicidal thoughts or actions in a small number of children, teenagers, and young adults during the first few months of treatment or when the dose is changed. Close monitoring by a healthcare provider is important during treatment. Do not suddenly stop taking the medication without consulting your doctor, as this can lead to withdrawal symptoms.

What happens if a dose of CLOFRANIL 25 MG TABLET is missed?

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. Consistency in taking the medication at the same time each day is recommended for optimal effectiveness.

How should CLOFRANIL 25 MG TABLET be stored?

CLOFRANIL 25 MG TABLET should be stored in a cool and dry place, away from direct sunlight. Keep it out of the sight and reach of children. The recommended storage temperature is typically between 10ºC to 25ºC or below 30ºC.