Oflomac Tz Tablet (10 Tab)

OFLOMAC TZ TABLET is a combination antibiotic medication manufactured by Macleods Pharmaceuticals Ltd., used to treat a wide range of bacterial and protozoal infections.

Name

• Brand Name: OFLOMAC TZ TABLET
• Common Name: Ofloxacin and Tinidazole Tablets

Composition

• Active Ingredients:
  • Ofloxacin 200 mg
  • Tinidazole 600 mg

Uses

OFLOMAC TZ TABLET is prescribed for various infections caused by susceptible bacteria and protozoans. These include:

• Mixed infections caused by bacteria and protozoa
• Diarrhea and dysentery (including amoebiasis and giardiasis)
• Pelvic inflammatory disease, endometritis, and pelvic cellulitis
• Intra-abdominal infections such as peritonitis and abscesses
• Vaginal infections
• Kidney or urinary bladder infections (e.g., cystitis, pyelonephritis, urethritis)
• Respiratory infections (e.g., bronchitis, pneumonia)
• Infections of bones, joints, skin, and soft tissues

Dosage and Administration

OFLOMAC TZ TABLET should be taken in the dose and duration advised by your doctor.

• It is recommended to take it with food and at a fixed time to achieve maximum effect and minimize stomach upset.
• Swallow the tablet whole with water; do not crush or chew.
• Complete the full course of treatment, even if symptoms improve, to ensure complete recovery and prevent antibiotic resistance.
• Do not take an extra dose to make up for a missed dose.
• This medicine is not recommended for use in children and adolescents below 18 years of age.

Side Effects

Common side effects may include:

• Nausea, vomiting, stomach pain, stomach upset
• Loss of appetite
• Headache, dizziness
• Changes in taste sensation (metallic taste)
• Dry mouth
• Diarrhea or constipation
• Weakness, difficulty sleeping

Serious side effects, though rare, require immediate medical attention:

• Allergic reactions (rashes, itching, swelling, shortness of breath)
• Tendonitis or tendon rupture
• Abnormal heartbeat
• Neurological effects (convulsions, tingling or burning sensation in hands and feet, changes in behavior, psychosis, depression, hallucination)
• Impaired vision or hearing
• Severe skin reactions (e.g., Stevens-Johnson syndrome)

Precautions

• Alcohol: Avoid consuming alcohol during treatment and for at least 3 days after stopping, as it can cause unpleasant side effects such as flushing, increased heart rate, nausea, and headache.
• Pregnancy and Breastfeeding: OFLOMAC TZ TABLET is generally not recommended during pregnancy or breastfeeding. Consult your doctor.
• Driving and Machinery: May cause dizziness and sleepiness, affecting alertness and coordination. Avoid driving or operating machinery if you experience these effects.
• Medical Conditions: Inform your doctor if you have liver disease, kidney disease, heart conditions (e.g., irregular heartbeat, QT prolongation), epilepsy, myasthenia gravis, G6PD deficiency, or a history of tendon problems.
• Drug Interactions: Inform your doctor about all other medications, supplements, and herbal products you are taking. Interactions can occur with blood thinners (e.g., warfarin), corticosteroids, and caffeine-containing products.
• Sun Exposure: Avoid excessive exposure to sunlight as it may increase photosensitivity.

Storage

• Store OFLOMAC TZ TABLET in a cool, dry place at room temperature (around 25°C).
• Keep away from direct sunlight and moisture.
• Always keep this medicine out of the reach of children.
• Dispose of unused medicine properly.

What is Oflomac TZ Tablet used for?

Oflomac TZ Tablet is primarily prescribed to treat a variety of mixed infections caused by specific bacteria and protozoa. It is used for conditions such as pelvic inflammatory disease, endometritis, pelvic cellulitis, and intra-abdominal infections like peritonitis and abscesses. It also effectively manages various types of diarrhea, including bacterial dysentery and traveler's diarrhea, as well as infections affecting the bones, joints, skin, and soft tissues. Additionally, it is used for giardiasis, amebiasis, vaginal infections, and infections in the kidney or urinary bladder.

How does Oflomac TZ Tablet work?

Oflomac TZ Tablet is a combination medication containing Ofloxacin (200 mg) and Tinidazole (600 mg). Ofloxacin, a fluoroquinolone antibiotic, works by inhibiting bacterial enzymes called DNA gyrase and topoisomerase IV, which are essential for bacterial DNA replication, transcription, and repair. This action ultimately leads to the death of the bacteria. Tinidazole, an antiprotozoal and antibacterial agent, functions by damaging the DNA of susceptible organisms, including protozoa and anaerobic bacteria, causing their cell death. Together, these two components provide broad-spectrum coverage against a wide range of bacterial and protozoal pathogens.

What is the usual dosage for Oflomac TZ Tablet?

The precise dosage of Oflomac TZ Tablet is determined by your doctor, taking into account individual factors such as your response to treatment and the severity of your condition. Generally, it is taken twice daily, with or without food. The duration of treatment can range from 3 days to 6 weeks, depending on the specific infection being treated. It is crucial to swallow the tablet whole with a glass of water and avoid crushing or chewing it. Always follow your doctor's instructions regarding dosage and do not alter it without consulting them.

What are the possible side effects of Oflomac TZ Tablet?

Common side effects of Oflomac TZ Tablet can include nausea, vomiting, diarrhea, stomach discomfort (dyspepsia), a metallic or bitter taste in the mouth, dizziness, headache, dry mouth, and loss of appetite. Less common but more serious side effects may include allergic reactions (such as skin rashes, itching, swelling, or shortness of breath), severe abdominal pain, and yellowing of the skin or eyes (jaundice). It is also important to be aware of potential risks like tendinitis and tendon rupture, which are serious side effects associated with fluoroquinolone antibiotics like Ofloxacin. If you experience any severe or worsening symptoms, contact your doctor immediately.

Is Oflomac TZ Tablet safe during pregnancy or breastfeeding?

Pregnancy: Oflomac TZ Tablet is contraindicated (not recommended) during pregnancy. The components of this medicine can potentially affect the growth and development of bones in an unborn baby. Breastfeeding: It is generally not recommended during breastfeeding as the medicine passes into breast milk. Women taking this medication should not breastfeed for at least 3 days after the last dose, and infants should be monitored for potential adverse effects like fungal infections of the mouth or diarrhea. Always consult your doctor if you are pregnant, planning to conceive, or breastfeeding.

Can Oflomac TZ Tablet be taken with other medications?

Oflomac TZ Tablet can interact with several other medications:

• Blood Thinners: Medicines such as warfarin and rivaroxaban may have increased effects when taken with this tablet, necessitating monitoring of clotting time.
• Caffeine-containing Medicines: Ofloxacin may increase caffeine levels in your body, potentially leading to increased side effects like nervousness, sleeplessness, and anxiety.
• Corticosteroids: Medicines like prednisone and dexamethasone can increase the risk of tendon rupture when taken with Ofloxacin.
• Painkillers (NSAIDs): Concomitant use of NSAIDs like naproxen, diclofenac, aspirin, and indomethacin should be avoided as it may increase the risk of fits.
• Acidity Medicines: Antacids containing magnesium or aluminum, sucralfate, or preparations containing zinc or iron, and certain anti-HIV drugs like didanosine, should be taken at least two hours before Oflomac TZ Tablet.
• Anti-diabetic Medicines: Close blood sugar monitoring is needed as Oflomac TZ Tablet may lead to low blood sugar levels.
• Mesoridazine: Using mesoridazine with Oflomac TZ Tablet can increase the risk of an irregular heart rhythm. Always inform your doctor about all medications, including over-the-counter drugs and herbal supplements, you are currently taking.

What precautions should be taken while using Oflomac TZ Tablet?

Several precautions should be observed when taking Oflomac TZ Tablet:

• Alcohol: Avoid consuming alcohol during treatment and for at least 3 days after stopping the medication, as it can cause unpleasant reactions such as flushing, increased heartbeat, nausea, thirst, chest pain, low blood pressure, and can exacerbate dizziness.
• Driving and Operating Machinery: This medicine may cause dizziness, sleepiness, visual disturbances, or drowsiness, so it's advisable to avoid driving or operating heavy machinery until you understand how it affects you.
• Pre-existing Medical Conditions: Inform your doctor if you have liver disease, kidney disease, myasthenia gravis (as it may worsen), G6PD deficiency, a history of seizures or epilepsy, tendinitis or tendon rupture, neurological disorders, diabetes, abnormal blood pressure, heart disease (such as irregular heartbeat), intestinal inflammation, severe skin problems, or psychiatric illness. Dosage adjustments may be necessary for some conditions.
• Sunlight Exposure: Limit exposure to direct sunlight as this medication may increase photosensitivity.
• Complete the Full Course: It is crucial to complete the entire course of treatment as prescribed by your doctor, even if your symptoms improve, to ensure the infection is fully cured and to prevent recurrence or the development of drug resistance.
• Hydration: Drink plenty of fluids throughout your treatment.
• Allergies: Do not use Oflomac TZ Tablet if you have a known allergy to ofloxacin, tinidazole, other fluoroquinolone antibiotics, other nitroimidazole antibiotics, or any other ingredients in the tablet.

What happens if a dose of Oflomac TZ Tablet is missed?

If you miss a dose of Oflomac TZ Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. Always consult your doctor before making any changes to your dosage.

How should Oflomac TZ Tablet be stored?

Oflomac TZ Tablet should be stored in a cool, dry place, ideally at room temperature (around 25°C). Keep it away from direct sunlight and moisture. Ensure the medicine is kept out of the reach of children. It is important to use the medicine before its expiry date. Keep it in the original packet or container, tightly closed.