Britzilam 10mg Inj

BRITZILAM 10MG INJ

BRITZILAM 10MG INJ is an antiepileptic medication manufactured by Torrent Pharmaceuticals Ltd (Neuron Division).

• Name:

  • Brand Name: Britzilam 10mg Injection
  • Common Name: Brivaracetam Injection

• Composition:

  • Each ml contains Brivaracetam 10 mg.

• Uses:

  • BRITZILAM 10MG INJ is primarily used for the management of partial-onset seizures in individuals with epilepsy.
  • It can be used as an adjunctive therapy (in combination with other antiepileptic drugs) or as monotherapy in adults.
  • It is also indicated for partial-onset seizures in adolescents and children over one month old.
  • Brivaracetam works by selectively binding to synaptic vesicle protein 2A (SV2A) in the brain, helping to regulate abnormal neuronal electrical activity and prevent the spread of electrical signals that trigger epileptic seizures.

• Dosage and Administration:

  • BRITZILAM 10MG INJ is administered parenterally, typically as an intravenous or intramuscular injection.
  • Administration should only be performed by a healthcare professional.
  • The recommended starting dose for adults is either 50 mg/day or 100 mg/day, divided into two equal doses (morning and evening).
  • The dosage can be adjusted based on individual patient response and tolerability, ranging from 50 mg/day to 200 mg/day.
  • When switching between oral and intravenous forms, the total daily dose and frequency should be maintained.

• Side Effects:

  • Common Side Effects: Drowsiness (somnolence), dizziness, fatigue, nausea, vomiting, irritability, anxiety, mood changes, and headaches.
  • Serious Side Effects: Suicidal thoughts and behavioral changes.

• Precautions:

  • Alcohol: Avoid alcohol consumption as it may worsen side effects like drowsiness and dizziness.
  • Driving/Operating Machinery: Exercise caution, as the medicine can cause dizziness, sleepiness, or affect vision.
  • Mental Health: Inform your doctor about any history of depression or mood disorders, as the medication may affect mood and can lead to suicidal ideation.
  • Withdrawal: Do not stop the medication abruptly without consulting a doctor, as gradual withdrawal is generally recommended to prevent increased seizure frequency.
  • Pregnancy & Breastfeeding: Consult a doctor. Limited human data, animal studies suggest potential risks during pregnancy. Information on breastfeeding is not readily available, so caution is advised.
  • Liver Impairment: Caution is advised for patients with liver disease, and dose adjustments may be necessary for severe cases.
  • Drug Interactions: Brivaracetam levels may be decreased by carbamazepine and phenytoin. Rifampin can reduce brivaracetam plasma concentrations. Concomitant use with other Central Nervous System (CNS) depressants (e.g., opioids, antidepressants) can increase drowsiness.

• Storage:

  • Store in a cool and dry place, away from direct sunlight.
  • Maintain a temperature below 30°C (or between 10°C to 25°C).
  • Keep out of the reach and sight of children.

BRITZILAM 10MG INJ by TORRENT PHARMA LTD (NEURON DIVISION) is an antiepileptic medication primarily used to manage partial-onset seizures. It contains Brivaracetam as its active ingredient.

What is BRITZILAM 10MG INJ used for?

BRITZILAM 10MG INJ is primarily used to control partial-onset seizures in adults, adolescents, and children over one month old with epilepsy. It can be used as an adjunctive therapy (along with other medications) or sometimes as monotherapy (by itself) for adults.

How does BRITZILAM 10MG INJ work?

BRITZILAM 10MG INJ, containing Brivaracetam, works by selectively binding to synaptic vesicle protein 2A (SV2A) in the brain. This action helps to regulate abnormal neuronal electrical activity and suppress the excessive spread of electrical impulses that trigger epileptic seizures.

What is the usual dosage of BRITZILAM 10MG INJ?

BRITZILAM 10MG INJ is administered as an injection by a healthcare professional. The recommended starting daily dose for adults and adolescents weighing 50kg or more is typically 50 mg/day or 100 mg/day, administered in two equally divided doses (morning and evening). The dose can be adjusted based on individual patient response and tolerability, ranging from 50 mg/day to 200 mg/day.

What are the possible side effects of BRITZILAM 10MG INJ?

Common side effects of BRITZILAM 10MG INJ include drowsiness, dizziness, fatigue, nausea, vomiting, irritability, and anxiety. Other reported side effects can include mood changes, headache, constipation, and insomnia. If these side effects persist or worsen, it's important to consult your doctor.

Is BRITZILAM 10MG INJ safe during pregnancy or breastfeeding?

BRITZILAM 10MG INJ may be unsafe to use during pregnancy as animal studies have shown harmful effects on the developing baby, and there is limited human data. It is generally not recommended during pregnancy, and women should consult their doctor if they are pregnant or planning to conceive. Information regarding its use during breastfeeding is limited, and it is advised to consult a doctor, as the effects on the newborn are not known.

Can BRITZILAM 10MG INJ be taken with other medications?

BRITZILAM 10MG INJ can interact with certain medications. For instance, antiepileptic medicines like carbamazepine and phenytoin may decrease Brivaracetam levels. Antibiotics such as rifampin can also reduce Brivaracetam levels, potentially undermining seizure control. Combining it with CNS depressants (e.g., opioids, antidepressants, antianxiety medicines) can increase drowsiness and sedation. Always inform your doctor about all medications, supplements, and herbal products you are taking to avoid potential interactions.

What precautions should be taken while using BRITZILAM 10MG INJ?

Caution should be exercised when using BRITZILAM 10MG INJ, especially in patients with liver disease, as dose adjustment may be needed. It can exacerbate existing neuropsychiatric conditions like depression or anxiety, and there is an increased risk of suicidal thoughts or behavior with antiepileptic drugs, including Brivaracetam. Patients should avoid alcohol while taking this medicine as it can increase drowsiness and other side effects. Due to potential drowsiness and dizziness, caution is advised when driving or operating machinery. Do not stop the medication abruptly without consulting your doctor, as this can increase the risk of seizures.

What should I do if a dose of BRITZILAM 10MG INJ is missed?

If you miss a dose of BRITZILAM 10MG INJ, you should consult with your doctor for advice. It is important to take doses at the appropriate time, and if a dose is missed, take it as soon as you remember. However, do not take a double dose to compensate for the missed one.

How should BRITZILAM 10MG INJ be stored?

BRITZILAM 10MG INJ should be stored in a cool and dry place, away from sunlight, at a temperature not exceeding 30ºC. It should be kept out of reach and sight of children.