Zukanorm D-10 Tab

ZUKANORM D-10 TAB by MANKIND PHARMA LTD

Name:

• Brand Name: Zukanorm D-10 Tablet
• Common Name: Dapagliflozin and Vildagliptin Tablets

Composition: Zukanorm D-10 Tablet contains two active ingredients:

• Dapagliflozin (10 mg): This is a selective sodium-glucose co-transporter 2 (SGLT2) inhibitor. It works by reducing the absorption of glucose in the kidneys and increasing its excretion through urine, thereby lowering blood glucose levels independently of insulin.
• Vildagliptin (100 mg): This ingredient is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It increases the levels of incretin hormones in the body, which helps control blood sugar by enhancing insulin release and decreasing glucagon production when glucose levels are high.

Uses: Zukanorm D-10 Tablet is primarily used to manage blood sugar levels in adults with Type 2 Diabetes Mellitus. It is used in conjunction with a healthy diet and regular exercise. The medication helps to improve glycemic control, manage high baseline HbA1c levels, and prevent long-term complications of diabetes such as kidney damage, blindness, nerve problems, and heart disease. It can be used as an initial combination therapy or as an add-on therapy to other antidiabetic medications.

Dosage and Administration: This medicine is taken orally. The dosage and timing should be strictly followed as prescribed by a doctor. It can be taken with or without food, preferably at the same time each day. Patients should not alter or exceed the prescribed dose or discontinue the medication without consulting their doctor.

Side Effects: Common side effects may include:

• Genital fungal infections (genital mycotic infections, vaginal inflammation, balanitis)
• Urinary tract infections (UTIs)
• Headache
• Nausea
• Back pain
• Joint pain (arthralgia)
• Upper respiratory tract infections, including nasopharyngitis
• Diarrhoea
• Dizziness, tremors, fatigue
• Hypoglycemia (low blood sugar level), especially when taken with other antidiabetic medicines or alcohol, or if meals are skipped.

If serious side effects or worsening of symptoms occur, a doctor should be consulted.

Precautions:

• Pregnancy and Breastfeeding: Caution is advised, and it is generally not recommended during pregnancy or breastfeeding. A doctor should be consulted for alternative treatment options.
• Alcohol: It is recommended to limit alcohol intake as it can increase the risk of hypoglycemia and lactic acidosis.
• Liver and Kidney Conditions: Patients with liver or kidney problems should discuss these with their doctor before starting Zukanorm D-10 Tablet. Caution is advised as it could potentially exacerbate kidney conditions.
• Hypotension: Individuals with low blood pressure should monitor their condition closely.
• Allergy: Avoid if allergic to Dapagliflozin, Vildagliptin, or any other components of the tablet.
• Driving and Operating Machines: Zukanorm D-10 Tablet may cause dizziness or fatigue, so caution is advised.
• Interactions: Inform your doctor about all other medicines, including diuretics (e.g., furosemide, hydrochlorothiazide), insulin, insulin secretagogues (e.g., glimepiride), and ACE inhibitors, to avoid potential interactions.
• Children: Not recommended for use in children as safety and effectiveness have not been established.

Storage: Store Zukanorm D-10 Tablet at room temperature, specifically below 30°C. It should be protected from direct light and moisture. Keep the medicine in an airtight container and out of reach of children and pets. Always check the expiry date before use.

Zukanorm D-10 Tablet is a medication prescribed for adults with type 2 diabetes mellitus. It combines two active ingredients, Dapagliflozin and Vildagliptin, to help manage blood sugar levels effectively when used in conjunction with a healthy diet and regular exercise.

Here are some frequently asked questions about Zukanorm D-10 Tablet:

What is Zukanorm D-10 Tablet used for?

Zukanorm D-10 Tablet is used to control high blood sugar levels in adults with type 2 diabetes mellitus. It works alongside diet and exercise to improve glycemic control and helps in preventing long-term complications associated with diabetes, such as kidney damage, vision problems, nerve issues, and heart disease. This medicine can be used as an initial combination therapy or as an add-on to other antidiabetic medications.

How does Zukanorm D-10 Tablet work?

This medicine contains two active components: Dapagliflozin (10 mg) and Vildagliptin (100 mg). Dapagliflozin, an SGLT2 inhibitor, works by reducing the reabsorption of glucose in the kidneys, leading to increased glucose excretion in the urine, thereby lowering blood sugar levels. Vildagliptin, a DPP-4 inhibitor, increases the levels of incretin hormones in the body. These hormones help regulate blood sugar by boosting insulin release and decreasing glucagon production when blood glucose levels are high.

What is the usual dosage for Zukanorm D-10 Tablet?

The dosage of Zukanorm D-10 Tablet is determined by your doctor based on your individual health condition and response to the medicine. It is crucial to adhere strictly to your prescribed dosage and not to alter it without consulting your doctor. The tablet can be taken with or without food, but it is recommended to take it at a fixed time each day for optimal results.

What are the possible side effects of Zukanorm D-10 Tablet?

Common side effects can include genital mycotic (fungal) infections, inflammation of the nasopharynx (nasopharyngitis), urinary tract infections, headache, upper respiratory tract infections, joint pain (arthralgia), back pain, diarrhea, and nausea. Other reported side effects include vomiting, dizziness, abdominal pain, frequent urination, and hypoglycemia (low blood sugar). Most side effects are temporary, but if you experience any serious or worsening symptoms, consult your doctor.

Is Zukanorm D-10 Tablet safe during pregnancy or breastfeeding?

Pregnancy: Caution is advised when considering Zukanorm D-10 Tablet during pregnancy, and it is generally not recommended unless the potential benefits outweigh the risks. Pregnant women should consult their doctor for personalized advice. Breastfeeding: Zukanorm D-10 Tablet is generally not recommended for breastfeeding mothers. It is important to consult your doctor for guidance on alternative treatment options.

Can Zukanorm D-10 Tablet be taken with other medications?

Zukanorm D-10 Tablet can interact with certain medications. For example, taking it with diuretics (e.g., furosemide, hydrochlorothiazide) may increase the risk of low blood pressure or dehydration. When taken with insulin or insulin secretagogues (e.g., glimepiride), there's an increased risk of hypoglycemia. Interactions with ACE inhibitors may also increase the risk of angioedema. Always inform your doctor about all other medicines, herbs, and supplements you are currently taking to avoid potential interactions.

What precautions should be taken while using Zukanorm D-10 Tablet?

Before starting Zukanorm D-10 Tablet, inform your doctor if you have any pre-existing medical conditions, especially liver or kidney problems, or low blood pressure. It's advisable to limit alcohol intake as it can increase the risk of hypoglycemia and lactic acidosis. This medicine may cause dizziness or fatigue, so exercise caution when driving or operating machinery. Regular monitoring of blood sugar levels is important. Maintaining good personal hygiene can help prevent genital fungal infections, which are a possible side effect. Zukanorm D-10 Tablet is not recommended for children as its safety and effectiveness have not been established. It is also not indicated for type 1 diabetes or diabetic ketoacidosis.

What happens if a dose of Zukanorm D-10 Tablet is missed?

If you miss a dose of Zukanorm D-10 Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. It is important not to stop taking this medicine without consulting your doctor first, as discontinuing it abruptly can worsen your diabetes.

How should Zukanorm D-10 Tablet be stored?

Zukanorm D-10 Tablet should be stored at room temperature, ideally below 30°C (some sources specify 20-25°C). Keep the medicine protected from direct light and moisture, preferably in an airtight container. Always ensure the medicine is kept out of the reach of children and check the expiry date before use.