Azulix Sm Ir 50/1000/1 Tab

AZULIX SM IR 50/1000/1 Tablet is an oral antidiabetic medication manufactured by Torrent Pharmaceuticals Ltd..

Name

• Brand Name: AZULIX SM IR 50/1000/1 Tablet

Composition

AZULIX SM IR 50/1000/1 Tablet is a combination medicine containing three active ingredients:

• Glimepiride: 1 mg
• Metformin: 1000 mg
• Sitagliptin: 50 mg

Uses

This medicine is prescribed for the management of Type 2 Diabetes Mellitus in adults when diet, exercise, and single-drug treatments do not provide sufficient blood sugar control. It works to:

• Manage elevated blood sugar levels.
• Improve glycemic balance by controlling blood sugar throughout the day.
• Enhance insulin function and sensitivity.
• Reduce glucose production by the liver and delay sugar absorption from the intestine.
• Prevent diabetes-related complications such as nerve damage, kidney issues, eye problems, and heart conditions.

Dosage and Administration

AZULIX SM IR 50/1000/1 Tablet should be taken exactly as prescribed by a doctor.

• It is typically taken orally, once or twice daily, preferably with or immediately after meals to minimize stomach upset.
• Swallow the tablet whole with a glass of water; do not crush, break, or chew it.
• Consistency in taking the medication at the same time(s) each day is crucial for optimal blood sugar control.
• Dosage may vary based on individual blood sugar levels and response to treatment, and regular monitoring of blood sugar levels is essential.

Side Effects

Common side effects may include:

• Hypoglycemia (low blood sugar), with symptoms like sweating, shakiness, confusion, and hunger.
• Nausea, vomiting, diarrhea, and abdominal pain.
• Headache.
• Upper respiratory tract infections, nasopharyngitis.
• Musculoskeletal pain.
• Frequent urination.
• Allergic reactions.
• Taste disturbance, flatulence, loss of appetite.

Serious side effects, though less common, require immediate medical attention:

• Lactic acidosis, indicated by extreme weakness, nausea, and abdominal pain.
• Severe allergic reactions such as skin rash, hives, swelling, and increased sensitivity to the sun.
• Inflammation of the liver (jaundice).
• Severe low blood sugar levels, including loss of consciousness or seizures.

Precautions

• Contraindications: Not recommended for patients with Type 1 diabetes mellitus, diabetic ketoacidosis, severe liver or kidney disease, acute heart problems, or active/history of bladder cancer.
• Alcohol Consumption: Avoid alcohol as it can increase the risk of hypoglycemia and lactic acidosis.
• Pregnancy and Breastfeeding: Consult a doctor, as it may be unsafe during pregnancy and breastfeeding.
• Kidney and Liver Impairment: Use with caution in patients with kidney or liver impairment, as dosage adjustments may be necessary due to increased risk of lactic acidosis or medication buildup.
• Children: Not recommended for use in children below 18 years of age.
• Drug Interactions: Inform your doctor about all other medications, including corticosteroids, calcium channel blockers, and sympathomimetics, as they can interact with AZULIX SM IR 50/1000/1 Tablet.
• Hypoglycemia Risk: Carry sugary food or fruit juice in case of low blood sugar symptoms.
• Driving/Operating Machinery: Exercise caution if experiencing dizziness or sleepiness.

Storage

Store in a cool and dry place, protected from moisture and light, at room temperature (below 30°C or between 20-25°C). Keep the medicine in its original packaging and out of the sight and reach of children.

Frequently Asked Questions about AZULIX SM IR 50/1000/1 TAB

What is AZULIX SM IR 50/1000/1 TAB used for?

AZULIX SM IR 50/1000/1 TAB is an antidiabetic medicine primarily used to treat Type 2 Diabetes Mellitus in adults. It is prescribed when diet, exercise, and other single-drug treatments are not sufficient to control blood sugar levels. This medication helps manage high blood sugar, improve glycemic control, and reduce the risk of diabetes-related complications such as nerve damage, kidney issues, eye problems, and heart conditions.

How does AZULIX SM IR 50/1000/1 TAB work?

This medicine is a combination of three active ingredients: Glimepiride, Metformin, and Sitagliptin, each working through different mechanisms. Glimepiride (a sulfonylurea) stimulates the pancreas to release more insulin. Metformin (a biguanide) reduces glucose production by the liver, decreases sugar absorption from the intestines, and improves the body's sensitivity to insulin. Sitagliptin (a DPP-4 inhibitor) increases the levels of natural substances (incretins) that help the pancreas release more insulin when blood sugar is high and signal the liver to reduce sugar production.

What is the usual dosage for AZULIX SM IR 50/1000/1 TAB?

The dosage of AZULIX SM IR 50/1000/1 TAB is individualized and determined by your doctor based on your blood sugar levels and response to treatment. It is typically taken orally with food, usually once or twice daily. It is crucial to follow the prescribed dosage and not to alter it without consulting your healthcare provider.

What are the possible side effects of AZULIX SM IR 50/1000/1 TAB?

Common side effects may include hypoglycemia (low blood sugar), nausea, vomiting, abdominal pain, diarrhea, headache, and upper respiratory tract infections. More serious but rare side effects can include lactic acidosis (associated with metformin) and pancreatitis (associated with sitagliptin). If you experience severe or persistent side effects, contact your doctor immediately.

Is AZULIX SM IR 50/1000/1 TAB safe during pregnancy or breastfeeding?

AZULIX SM IR 50/1000/1 TAB is generally not recommended during pregnancy, especially during the second and third trimesters, as it may harm the unborn baby. It is also contraindicated for breastfeeding mothers as components of the medicine can pass into breast milk. Always inform your doctor if you are pregnant, planning pregnancy, or breastfeeding before taking this medication.

Can AZULIX SM IR 50/1000/1 TAB be taken with other medications?

This medicine can interact with other medications, potentially affecting their effectiveness or increasing the risk of side effects. It's important to inform your doctor about all medicines, supplements, and herbal products you are currently taking. Some notable interactions include corticosteroids, calcium channel blockers, certain antibiotics (like rifampin), and insulin or other insulin secretagogues, which may increase the risk of hypoglycemia.

What precautions should be taken with AZULIX SM IR 50/1000/1 TAB?

Avoid alcohol consumption while taking this medicine as it can increase the risk of hypoglycemia and lactic acidosis. It is not recommended for patients with severe liver or kidney disease, Type 1 diabetes mellitus, or diabetic ketoacidosis. Regular monitoring of blood sugar levels is essential. If you experience symptoms of low blood sugar, carry sugary food or juice. Caution is also advised for elderly patients who may require dose adjustments.

What happens if a dose of AZULIX SM IR 50/1000/1 TAB is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for a missed one, as this can lead to a dangerous drop in blood glucose levels.

How should AZULIX SM IR 50/1000/1 TAB be stored?

AZULIX SM IR 50/1000/1 TAB should be stored in a cool, dry place, typically below 25°C, and protected from moisture and direct sunlight. Keep the medicine in its original packaging in a tightly sealed container and out of the sight and reach of children. Do not use the medicine after the expiry date printed on the package.