Mesacol Suppository 1gm

MESACOL SUPPOSITORY 1GM by SUN PHARMA-SYGNUS DIV

Name:

• Brand Name: Mesacol 1g Suppository
• Common Name/Active Ingredient: Mesalazine (also known as Mesalamine or 5-Aminosalicylic Acid)

Composition: Each suppository contains 1 gram of Mesalazine as the active ingredient.

Uses: Mesacol 1g Suppository is an anti-inflammatory medicine primarily used to treat inflammatory bowel diseases. It is prescribed for:

• Ulcerative Colitis: A chronic inflammatory bowel disease causing inflammation and ulcers in the large intestine and rectum. It helps reduce symptoms like diarrhea, bleeding, and stomach pain.
• Ulcerative Proctitis: A condition where ulcerative colitis specifically affects the rectum.
• Crohn's Disease: Used in mild to moderate cases, especially when affecting the lower bowel, to reduce inflammation and manage flare-ups.

Dosage and Administration: This medicine is for rectal use only and should not be taken orally. It must be used under the supervision of a doctor or healthcare professional.

• Typical Guidance: Insert rectally, often once daily at bedtime.
• Administration: After inserting the suppository, remain in a lying position for at least 15 minutes to allow for proper absorption and to prevent it from coming out. The exact dose and duration depend on the condition being treated and your doctor's prescription.

Side Effects: Common side effects may include:

• Rectal discomfort or irritation
• Headache
• Nausea
• Abdominal pain or cramps
• Rash or skin reactions
• Diarrhea or flatulence
• Fever (rare)

Precautions:

• Allergies: Inform your doctor if you are allergic to Mesalazine, aspirin, or sulfasalazine.
• Kidney and Liver Issues: Use with caution in patients with kidney or liver disease. It is not recommended for those with severe kidney or liver impairment.
• Pregnancy and Breastfeeding: Consult your doctor before use, as it may be unsafe during pregnancy and is probably unsafe during breastfeeding.
• Drug Interactions: Be cautious when taking with Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) like ibuprofen, immunosuppressants (e.g., azathioprine), or blood thinners like warfarin.
• Fluid Intake: Ensure adequate fluid intake during treatment to help prevent kidney stones.
• Monitoring: Your doctor may monitor kidney, liver, blood, and lung function periodically during treatment.

Storage: Store Mesacol 1g Suppositories in a cool, dry place, away from direct sunlight, moisture, and heat. The storage temperature should not exceed 25°C or be below 30°C. Keep the medicine in its original packaging and out of the reach of children and pets.

Here are some frequently asked questions and answers about MESACOL SUPPOSITORY 1GM:

What is MESACOL SUPPOSITORY 1GM used for?

MESACOL SUPPOSITORY 1GM is primarily used to treat inflammatory bowel diseases such as ulcerative colitis and ulcerative proctitis. It is specifically effective when the inflammation affects the lining of the inner rectum (proctitis) and helps reduce symptoms like diarrhea, bleeding, and stomach pain by alleviating inflammation in the bowel. It can also be used in mild to moderate cases of Crohn's disease that affect the lower bowel.

How does MESACOL SUPPOSITORY 1GM work?

MESACOL SUPPOSITORY 1GM contains mesalazine (also known as mesalamine or 5-aminosalicylic acid), which is an aminosalicylate. It works directly on the site of inflammation in the lower parts of the large intestine (colon and rectum). Mesalazine reduces inflammation by inhibiting the production of certain chemical messengers, such as prostaglandins and leukotrienes, that cause pain, swelling, and inflammation in the intestinal lining.

What is the usual dosage for MESACOL SUPPOSITORY 1GM?

MESACOL SUPPOSITORY 1GM is for rectal use only and should not be taken orally. The exact dosage and duration of treatment will be prescribed by your doctor, depending on your condition. A common regimen for adults is one suppository inserted rectally once or twice daily, often at bedtime to maximize contact time with the rectal mucosa. After insertion, it is recommended to remain in a lying position for at least 15 minutes to allow proper absorption and to avoid passing stools for at least 1 hour.

What are the possible side effects of MESACOL SUPPOSITORY 1GM?

Common side effects may include rectal discomfort, rash, itching, fever, headache, nausea, abdominal pain, diarrhea, and flatulence. If these symptoms are bothersome, persist, or worsen, you should inform your doctor.

Is MESACOL SUPPOSITORY 1GM safe during pregnancy or breastfeeding?

Pregnancy: MESACOL SUPPOSITORY 1GM may be unsafe to use during pregnancy. While limited human studies exist, animal studies have indicated harmful effects on the developing baby. You should consult your doctor before using this medicine during pregnancy, as they will weigh the potential benefits against any risks.

Breastfeeding: MESACOL SUPPOSITORY 1GM is likely unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into breastmilk and could potentially harm the baby, possibly causing diarrhea. If you are breastfeeding and taking this medication, your baby should be monitored for diarrhea. Consult your doctor before using it while breastfeeding.

Can MESACOL SUPPOSITORY 1GM be taken with other medications?

It is crucial to inform your doctor about all other medications, herbal preparations, and supplements you are taking to avoid potential drug interactions. Caution is advised when taking MESACOL SUPPOSITORY 1GM with immunosuppressants like azathioprine, 6-mercaptopurine, and thioguanine, as this combination may increase the risk of blood disorders. It may also interact with non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, potentially increasing the risk of kidney problems. Additionally, it can decrease the effect of blood thinners like warfarin. Avoid taking antacids with this suppository as it can make inflammation worse.

What precautions should be taken when using MESACOL SUPPOSITORY 1GM?

• This medicine is for rectal use only; do not swallow it.
• Inform your doctor if you have any kidney or liver problems, lung diseases like asthma, heart problems, stomach blockage, or a history of allergies to mesalazine, aspirin, or sulfasalazine.
• Ensure adequate fluid intake during treatment, as mesalazine may lead to kidney stone formation.
• Your doctor may recommend kidney and liver function tests before and during treatment.
• Do not stop taking the medicine early, even if your symptoms improve, as stopping prematurely can lead to symptom recurrence and worsening of your condition.
• Use with caution in elderly patients.
• While there are no known interactions between alcohol and Mesacol Suppository, it is generally advisable to limit alcohol consumption if you have ulcerative colitis, as it can irritate the stomach and intestines.

What happens if a dose of MESACOL SUPPOSITORY 1GM is missed?

If you miss a dose, take it as soon as you remember, provided it is not almost time for your next scheduled dose. Do not take two doses at once to make up for a missed dose.

How should MESACOL SUPPOSITORY 1GM be stored?

Store MESACOL SUPPOSITORY 1GM in a cool and dry place, protected from direct sunlight, moisture, and heat. The storage temperature should not exceed 25°C. Keep the medicine in its original packaging and out of the sight and reach of children and pets. Do not use expired or damaged medicine.