Ticaplat 90

TICAPLAT 90 is a medication manufactured by EMCURE PHARMACEUTICALS LTD, primarily used to prevent serious cardiovascular events.

Name

• Brand Name: TICAPLAT 90
• Common Name: Ticagrelor

Composition

• Active Ingredient: Ticagrelor 90 mg

Uses

TICAPLAT 90 (Ticagrelor) is an antiplatelet medicine that helps prevent the formation of harmful blood clots. It is prescribed for:

• Prevention of atherothrombotic events in adult patients with Acute Coronary Syndrome (ACS).
• Reducing the risk of heart attack and stroke in patients with a history of heart attack or those at high risk of developing blood clots.
• Management of patients with Coronary Artery Disease (CAD) at high risk of heart attack or stroke.
• Prevention of stent thrombosis in patients who have undergone Percutaneous Coronary Intervention (PCI).

Dosage and Administration

TICAPLAT 90 is typically taken orally, with or without food. The dosage is determined by a doctor based on the patient's condition.

• Initial Treatment (Acute Coronary Syndrome): Often initiated with a 180 mg loading dose (two 90 mg tablets), followed by a 90 mg maintenance dose twice daily for the first year after an ACS event.
• Maintenance Dose (After one year): May be reduced to 60 mg twice daily after one year, as advised by a physician.
• This medicine is usually prescribed along with a low dose of aspirin (75-100 mg daily) to enhance its protective effect against clot-related events. Do not crush, chew, or break the tablet. It is crucial not to stop taking this medication without consulting a doctor, as abrupt discontinuation can increase the risk of heart attack or stroke.

Side Effects

Common side effects of TICAPLAT 90 include:

• Easy bruising or increased tendency to bleed.
• Dyspnoea (shortness of breath).
• Headache.
• Dizziness.
• Nausea.
• Diarrhoea.
• Increased uric acid levels.

Serious side effects, though less common, can include severe or uncontrollable bleeding, black, tarry stools, blood in urine or stools, or coughing up blood. If any severe bleeding or unusual symptoms occur, immediate medical attention is necessary.

Precautions

• Bleeding Risk: TICAPLAT 90 can increase the risk of serious bleeding. It is contraindicated in patients with active pathological bleeding (e.g., from peptic ulcers or head injury) or a history of intracranial hemorrhage.
• Surgery: Inform all healthcare providers, including dentists, that you are taking this medicine, as it may need to be stopped temporarily before surgery or other medical procedures to prevent excessive bleeding.
• Liver Impairment: Avoid use in patients with severe liver disease.
• Pregnancy and Breastfeeding: Not recommended during pregnancy, and breastfeeding is generally not advised while using this medicine. Consult a doctor if pregnant or breastfeeding.
• Alcohol: Avoid alcohol consumption as it can increase the risk of bleeding.
• Other Medications: Inform your doctor about all medications, including over-the-counter drugs and supplements, as interactions can occur. High doses of aspirin (above 100 mg daily) can decrease the effectiveness of ticagrelor. Avoid strong CYP3A inhibitors.
• Children: Safety and effectiveness in children under 18 years of age have not been established.
• Driving/Operating Machinery: May cause dizziness, which could affect the ability to drive or operate machinery.

Storage

Store TICAPLAT 90 tablets in a closed container at room temperature, between 20°C to 25°C (68°F to 77°F), away from heat, moisture, and direct light. Keep the medicine out of the reach of children. Do not keep outdated medicine or medicine no longer needed.

TICAPLAT 90 is a medication containing ticagrelor, an antiplatelet agent used to prevent blood clots and reduce the risk of serious cardiovascular events.

Here are some frequently asked questions about TICAPLAT 90:

What is TICAPLAT 90 used for?

TICAPLAT 90 (ticagrelor) is used to prevent blood clots, heart attacks, and strokes. It is commonly prescribed for individuals who have experienced acute coronary syndrome (ACS), a heart attack, or have coronary artery disease (CAD) and are at high risk for such events. It is also used to reduce the risk of blood clots in patients who have received stents to treat ACS, and to prevent stroke in patients with acute ischemic stroke or high-risk transient ischemic attack (TIA).

How does TICAPLAT 90 work?

TICAPLAT 90 works as an antiplatelet medication, specifically a P2Y12 platelet inhibitor. It prevents platelets (blood cells involved in clotting) from clumping together and forming harmful blood clots in the arteries. This action helps to maintain smooth blood flow and reduces the risk of blockages that can lead to heart attacks and strokes.

What is the usual dosage of TICAPLAT 90?

The dosage of TICAPLAT 90 can vary depending on the condition being treated.

• For Acute Coronary Syndrome (ACS) or a history of heart attack: Treatment typically starts with a single loading dose of 180 mg (two 90 mg tablets). This is followed by a maintenance dose of 90 mg twice daily for up to one year. After one year, your doctor might reduce the dose to 60 mg twice daily.
• For prevention of stroke in patients with acute ischemic stroke or high-risk TIA: An initial loading dose of 180 mg is given, followed by 90 mg twice daily for up to 30 days.
• For Coronary Artery Disease (CAD) without prior stroke or heart attack: The usual dose is 60 mg twice daily.

TICAPLAT 90 is often taken along with a daily maintenance dose of aspirin (75-100 mg). Always follow your doctor's specific dosing instructions.

What are the possible side effects of TICAPLAT 90?

Common side effects include bleeding (e.g., nosebleeds, bruising easily, heavier periods, bleeding gums), shortness of breath (dyspnea), headache, dizziness, nausea, indigestion, and diarrhea. Serious bleeding is a significant risk with this medication, and you should contact your doctor immediately if you experience severe, unexplained, or uncontrollable bleeding, or signs like coughing up blood, vomiting blood, or black, tarry stools.

Is TICAPLAT 90 safe during pregnancy or breastfeeding?

TICAPLAT 90 is generally not recommended during pregnancy or if you are trying to become pregnant due to limited safety information and potential risks to the fetus observed in animal studies. For breastfeeding, it is advisable to consult your doctor or pharmacist. Ticagrelor may pass into breast milk, and a decision on whether to continue breastfeeding or take the medication should be made based on the potential benefits and risks.

Can TICAPLAT 90 be taken with other medications?

Yes, but caution is necessary due to potential drug interactions. TICAPLAT 90 is often prescribed with low-dose aspirin (75-100 mg). However, taking more than 100 mg of aspirin per day can reduce the effectiveness of ticagrelor.

Other medications that can interact with TICAPLAT 90 and may increase the risk of bleeding or affect its efficacy include:

• Other blood thinners (e.g., warfarin, rivaroxaban, clopidogrel).
• Non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen.
• Certain antibiotics (e.g., clarithromycin, rifampicin).
• Antifungal medicines (e.g., ketoconazole, itraconazole, voriconazole).
• HIV medicines (e.g., atazanavir, ritonavir).
• Certain seizure medications (e.g., phenytoin, carbamazepine, phenobarbital).
• Some statins (e.g., simvastatin, lovastatin) – doses may need to be adjusted.
• Digoxin (for heart problems) – digoxin levels should be monitored.
• Opioids (e.g., morphine, oxycodone, hydrocodone).

Always inform your doctor and pharmacist about all prescription, over-the-counter, vitamin, and herbal supplements you are taking.

What precautions should be taken while taking TICAPLAT 90?

• Bleeding Risk: TICAPLAT 90 increases the risk of bleeding. Be careful with activities that could cause injury, and report any unusual bleeding or bruising to your doctor immediately.
• Surgery and Dental Work: Inform all healthcare providers, including dentists, that you are taking TICAPLAT 90 before any surgery or medical procedure. Your doctor may advise you to stop taking the medication at least 5 days prior to surgery to minimize bleeding risk.
• Liver Problems: Use with caution if you have liver problems, and it is contraindicated in severe liver disease.
• Do Not Stop Abruptly: Do not stop taking TICAPLAT 90 without consulting your doctor. Suddenly stopping the medication can significantly increase your risk of heart attack or stroke.
• Dyspnea: Some patients may experience shortness of breath. If you develop new, prolonged, or worsened dyspnea, inform your doctor.

What happens if a dose of TICAPLAT 90 is missed?

If you miss a dose of TICAPLAT 90, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you remember within a few hours of the scheduled time, you may take the missed dose immediately, but do not double up on your next dose.

How should TICAPLAT 90 be stored?

Store TICAPLAT 90 tablets at room temperature, generally between 68-77°F (20-25°C), away from excess heat and moisture. Keep the medication in its original container, tightly closed, and out of reach of children and pets. Do not store it in the bathroom.