Macralfate Syrup

MACRALFATE SYRUP by MACLEODS PHARMACEUTICALS LTD

Macralfate Syrup, manufactured by Macleods Pharmaceuticals Ltd., is a medication primarily used for gastrointestinal conditions.

• Name: Macralfate Syrup (Brand name), Sucralfate (Common name).
• Composition: The active ingredient in Macralfate Syrup is Sucralfate, commonly found in a concentration of 1000mg/10ml. Sucralfate works by forming a protective barrier over ulcer sites, shielding them from stomach acid, enzymes, and bile salts, thereby promoting healing.
• Uses: Macralfate Syrup is prescribed for the treatment and management of various gastrointestinal issues, including:
  • Stomach ulcers (gastric ulcers) and intestinal ulcers (duodenal ulcers).
  • Prevention of stress ulcers in critically ill patients.
  • Management of chronic gastritis.
  • Alleviating symptoms of Gastroesophageal Reflux Disease (GERD) and heartburn by protecting the esophagus from stomach acid.
• Dosage and Administration:
  • Typically taken on an empty stomach, about one hour before meals or two hours after meals, and often at bedtime.
  • Shake the bottle well before use.
  • Adults: For duodenal ulcers, a common dosage is 1 gram (approximately 10 ml) four times a day for 4 to 8 weeks.
  • Do not take antacids within 30 minutes to 2 hours of Macralfate Syrup to avoid interfering with its effectiveness.
• Side Effects: Common side effects may include:
  • Constipation (most common).
  • Dry mouth.
  • Nausea, vomiting, or indigestion.
  • Dizziness, drowsiness, or headache.
  • Less common side effects include skin rash.
• Precautions:
  • Inform your doctor if you have kidney disease, as Sucralfate contains aluminum, which can accumulate in the body.
  • Use with caution in diabetic patients as it may cause a rise in blood glucose levels.
  • Limited safety information is available for use during pregnancy and breastfeeding; consult your doctor.
  • Macralfate can interact with and reduce the absorption of other medications (e.g., certain antibiotics, cimetidine, ranitidine, digoxin). Maintain a 2-hour gap between taking Macralfate and other medicines.
  • Avoid alcohol, as it can worsen ulcer pain and hinder healing.
  • Avoid driving or operating heavy machinery if experiencing dizziness or sleepiness.
• Storage: Store at room temperature (typically between 10°C to 30°C). Keep away from direct sunlight, heat, moisture, and out of the reach of children.

Here are frequently asked questions about Macralfate Syrup/Suspension:

What is Macralfate Syrup/Suspension used for?

Macralfate Syrup/Suspension is primarily used to treat and prevent peptic ulcers, including gastric and duodenal ulcers. It is also used for managing conditions like gastroesophageal reflux disease (GERD), acidity, heartburn, and gastritis. Some formulations containing Oxetacaine also provide relief from pain associated with these conditions and post-meal acid reflux.

How does Macralfate Syrup/Suspension work?

Macralfate, with its active ingredient sucralfate, works by forming a protective barrier or coat over the ulcerated areas in the stomach and intestine. This barrier shields the ulcer from stomach acid, pepsin, and bile salts, preventing further irritation and allowing the ulcer to heal. Some variants, like Macralfate-O Suspension, also contain Oxetacaine, which acts as a local anesthetic to relieve pain and may inhibit acid production.

What is the usual dosage for Macralfate Syrup/Suspension?

Macralfate Syrup/Suspension should be taken exactly as prescribed by your doctor. It is generally recommended to take it on an empty stomach, typically one hour before meals, and often at bedtime. Shake the bottle well before use and use a measuring cup or spoon for accurate dosage. The dose may vary based on your condition and response to the medicine.

What are the possible side effects of Macralfate Syrup/Suspension?

Common side effects include constipation, nausea, vomiting, headache, dry mouth, dizziness, sleepiness, indigestion, and skin rash. Less common effects may include bloating, hives, and trouble sleeping. If these side effects persist or worsen, consult your doctor.

Is Macralfate Syrup/Suspension safe during pregnancy or breastfeeding?

For pregnancy, Macralfate Syrup/Suspension is generally considered safe, but caution is advised, and you should consult your doctor before use. Limited human studies suggest it does not harm the unborn baby, but more research is needed. For breastfeeding, it is generally considered safe as it is minimally absorbed into the bloodstream, making it unlikely to pass into breast milk in significant amounts. However, it is advisable to consult your doctor.

Can Macralfate Syrup/Suspension be taken with other medications?

Macralfate can interact with certain medications, reducing their effectiveness. It may bind to drugs like digoxin, warfarin, levothyroxine, phenytoin, ciprofloxacin, ketoconazole, and certain antibiotics (e.g., tetracyclines, minocycline), preventing their absorption. To avoid interactions, it is typically recommended to take other medications at least two hours before or after Macralfate Syrup/Suspension. Always inform your doctor about all medications, supplements, and herbal products you are taking.

What precautions should be taken while using Macralfate Syrup/Suspension?

Inform your doctor if you have kidney disease, as Macralfate contains aluminum which can accumulate in the body. Patients with diabetes should use it with caution, as it may cause a rise in blood glucose levels. Avoid alcohol consumption, as it can irritate the stomach lining and interfere with healing. Macralfate Suspension is generally not recommended for use in children under 12 years of age as safety and efficacy data is limited. It may also cause dizziness or sleepiness, so avoid driving or operating heavy machinery if you experience these effects.

What happens if a dose of Macralfate Syrup/Suspension is missed?

If you miss a dose, take it as soon as you remember. However, if it's nearly time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should Macralfate Syrup/Suspension be stored?

Macralfate Syrup/Suspension should be stored at room temperature, ideally below 30°C. Keep it away from direct sunlight and moisture, and out of the reach of children and pets.