Dalstep Tablet ( 10 Tablet )

DALSTEP TABLET

Dalstep Tablet is a medication manufactured by Sun Pharmaceutical Industries Ltd., primarily used to enhance walking ability in adults with Multiple Sclerosis (MS).

Composition

• Active Ingredient: Dalfampridine 10mg.

Uses

Dalstep Tablet belongs to a class of drugs known as potassium channel blockers. It is prescribed to improve walking in individuals diagnosed with Multiple Sclerosis (MS), a condition where the immune system attacks the protective covering of nerves. The active ingredient, dalfampridine, works by blocking potassium channels in nerve cells, which helps to reinforce nerve impulses transmitted by the brain through affected nerves, thereby improving muscular function and walking speed. This medication is not a cure for MS but aids in managing symptoms and enhancing quality of life.

Dosage and Administration

Dalstep Tablet is typically taken orally, usually one tablet twice daily, approximately 12 hours apart. It can be taken with or without food. The tablet should be swallowed whole with water and must not be crushed, chewed, or broken, as this could affect the release of the medication and increase the risk of side effects. It is important not to exceed the maximum recommended dose of 20 mg per day. If a dose is missed, it should be skipped, and the next dose should be taken at the regular time; do not take two doses at once.

Side Effects

Common side effects may include:

• Urinary tract infection (UTI)
• Insomnia/Sleep disturbance
• Dizziness
• Headache
• Nausea
• Weakness
• Back pain
• Balance disorder (loss of balance)
• Paresthesia (tingling or pricking sensation)
• Constipation
• Throat irritation/pain
• Nasal irritation
• Indigestion

If side effects persist or worsen, medical attention should be sought.

Precautions

• Seizure Risk: Dalstep Tablet is contraindicated in individuals with a history of seizures, as it can increase the risk.
• Kidney Impairment: It should not be used by people with moderate to severe kidney problems, as it may increase side effects and worsen existing conditions.
• Pregnancy and Breastfeeding: Not generally recommended during pregnancy unless clearly needed and benefits outweigh risks, and should not be used while breastfeeding.
• Alcohol: Avoid alcohol consumption as it may increase side effects like dizziness and excessive drowsiness.
• Driving/Operating Machinery: May cause dizziness, so caution is advised when performing tasks requiring alertness.
• Age Restriction: Not recommended for patients younger than 18 years of age due to unestablished safety and effectiveness.
• Liver Impairment: Patients with liver disorders should use with caution.
• Inform your doctor about any pre-existing medical conditions or other medications being taken to avoid potential interactions.

Storage

Store Dalstep Tablet in a cool and dry place, typically between 15ºC to 30ºC (or below 30ºC). Keep it in its original packaging to protect it from light and moisture. Keep this medicine out of the sight and reach of children. Do not use the medicine after its expiry date.

What is Dalstep Tablet used for?

Dalstep Tablet is primarily used to improve walking ability in adults with multiple sclerosis (MS). It helps to enhance mobility, walking speed, and independence for individuals managing daily activities affected by MS.

How does Dalstep Tablet work?

Dalstep Tablet contains Dalfampridine (10 mg), which is a potassium channel blocker. It works by blocking potassium channels in nerve cells, which helps to improve nerve signal transmission in areas of the brain and spinal cord damaged by MS. This mechanism strengthens the communication between nerves and muscles, leading to improved muscle activity and walking function.

What is the usual dosage of Dalstep Tablet?

The usual recommended starting dose for adults is one 10 mg tablet, taken twice daily, approximately 12 hours apart. It can be taken with or without food. It is crucial to swallow the tablet whole and not to crush, chew, or break it, as this can affect the medication's release and increase the risk of side effects. The maximum recommended dose is 20 mg per day.

What are the possible side effects of Dalstep Tablet?

Common side effects of Dalstep Tablet may include urinary tract infection (UTI), dizziness, insomnia (difficulty sleeping), headache, nausea, weakness, and constipation. Other reported side effects can include back pain, balance disorder, paresthesia (tingling or pricking sensation), and throat irritation. Most side effects are temporary; however, if they persist or worsen, it is important to consult your doctor.

Is Dalstep Tablet safe during pregnancy or breastfeeding?

Dalstep Tablet is generally not recommended during pregnancy unless clearly needed and the potential benefits outweigh the risks, as animal studies have shown harmful effects on the developing baby. It is also not recommended during breastfeeding, as Dalfampridine may pass into breast milk and potentially harm the baby.

Can Dalstep Tablet be taken with other medications?

Dalstep Tablet can interact with certain medications. For example, stomach acid reducers like Cimetidine may increase Dalfampridine levels, potentially leading to toxicity. Other seizure medications (e.g., Phenytoin, Carbamazepine) may reduce the effectiveness of Dalstep Tablet. It can also interact with medications affecting kidney function, increasing the risk of side effects. Always inform your doctor about all medications you are taking, including over-the-counter drugs, herbal tonics, and supplements, to avoid potential interactions.

What precautions should be taken while taking Dalstep Tablet?

It is important to inform your doctor if you have a history of seizures or kidney problems, as Dalstep Tablet is contraindicated in patients with a history of seizures and moderate to severe renal impairment due to an increased risk of seizures. Caution is also advised for patients with liver disorders and elderly patients. Alcohol consumption should be avoided as it may increase side effects like dizziness.

What happens if a dose of Dalstep Tablet is missed?

If you miss a dose of Dalstep Tablet, skip the missed dose and take your next dose at the regularly scheduled time. Do not take a double dose to make up for the missed one. It is essential to maintain a 12-hour interval between doses.

How should Dalstep Tablet be stored?

Dalstep Tablet should be stored in a cool, dry place, typically between 15°C to 30°C, away from direct sunlight. Keep the tablets in their original packaging to protect them from light and moisture, and out of the reach of children. Do not use the medicine after its expiry date.